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Objective: Cone-beam computed tomography (CBCT) provides a low-dose imaging alternative to conventional CT, but suffers from noise, scatter, and artifacts that degrade image quality. Synthetic CT (sCT) aims to translate CBCT to high-quality…
Computed Tomography (CT) is a widely utilized imaging modality in clinical settings. Using densely acquired rotational X-ray arrays, CT can capture 3D spatial features. However, it is confronted with challenged such as significant time…
Multi-modal magnetic resonance imaging (MRI) provides rich, complementary information for analyzing diseases. However, the practical challenges of acquiring multiple MRI modalities, such as cost, scan time, and safety considerations, often…
In this article, we present a Latent Diffusion Model (LDM) for the generation of brain Magnetic Resonance Imaging (MRI), conditioning its generation based on pathology (Healthy, Glioblastoma, Sclerosis, Dementia) and acquisition modality…
Data scarcity in medical imaging poses significant challenges due to privacy concerns. Diffusion models, a recent generative modeling technique, offer a potential solution by generating synthetic and realistic data. However, questions…
Multi-modal images play a crucial role in comprehensive evaluations in medical image analysis providing complementary information for identifying clinically important biomarkers. However, in clinical practice, acquiring multiple modalities…
Computed tomography (CT) serves as an effective tool for lung cancer screening, diagnosis, treatment, and prognosis, providing a rich source of features to quantify temporal and spatial tumor changes. Nonetheless, the diversity of CT…
Computed tomography (CT) is one of the modalities for effective lung cancer screening, diagnosis, treatment, and prognosis. The features extracted from CT images are now used to quantify spatial and temporal variations in tumors. However,…
Objective: While recent advances in text-conditioned generative models have enabled the synthesis of realistic medical images, progress has been largely confined to 2D modalities such as chest X-rays. Extending text-to-image generation to…
Latent diffusion models (LDMs) dominate high-quality image generation, yet integrating representation learning with generative modeling remains a challenge. We introduce a novel generative image modeling framework that seamlessly bridges…
Human organs constantly undergo anatomical changes due to a complex mix of short-term (e.g., heartbeat) and long-term (e.g., aging) factors. Evidently, prior knowledge of these factors will be beneficial when modeling their future state,…
Scaling by training on large datasets has been shown to enhance the quality and fidelity of image generation and manipulation with diffusion models; however, such large datasets are not always accessible in medical imaging due to cost and…
Magnetic Resonance (MR) imaging plays an essential role in contemporary clinical diagnostics. It is increasingly integrated into advanced therapeutic workflows, such as hybrid Positron Emission Tomography/Magnetic Resonance (PET/MR) imaging…
Latent Diffusion models (LDMs) have achieved remarkable results in synthesizing high-resolution images. However, the iterative sampling process is computationally intensive and leads to slow generation. Inspired by Consistency Models (song…
Generative models based on deep learning have shown significant potential in medical imaging, particularly for modality transformation and multimodal fusion in MRI-based brain imaging. This study introduces GM-LDM, a novel framework that…
Image-to-Image translation models can help mitigate various challenges inherent to medical image acquisition. Latent diffusion models (LDMs) leverage efficient learning in compressed latent space and constitute the core of state-of-the-art…
We investigate the utility of diffusion generative models to efficiently synthesise datasets that effectively train deep learning models for image analysis. Specifically, we propose novel $\Gamma$-distribution Latent Denoising Diffusion…
Medical image segmentation is a critical step in computer-aided diagnosis, and convolutional neural networks are popular segmentation networks nowadays. However, the inherent local operation characteristics make it difficult to focus on the…
Limited-angle computed tomography (LACT) offers improved temporal resolution and reduced radiation dose for cardiac imaging, but suffers from severe artifacts due to truncated projections. To address the ill-posedness of LACT…
Limited-angle computed tomography (LACT) reconstruction is an inverse problem with severe ill-posedness arising from missing projection angles, and it is difficult to restore high-precision images without sufficient prior knowledge. In…