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To discover new drugs is to seek and to prove causality. As an emerging approach leveraging human knowledge and creativity, data, and machine intelligence, causal inference holds the promise of reducing cognitive bias and improving decision…

Quantitative Methods · Quantitative Biology 2025-04-09 Tom Michoel , Jitao David Zhang

Most causal discovery algorithms find causal structure among a set of observed variables. Learning the causal structure among latent variables remains an important open problem, particularly when using high-dimensional data. In this paper,…

Machine Learning · Computer Science 2020-09-09 Jonathan D. Young , Bryan Andrews , Gregory F. Cooper , Xinghua Lu

Learning causal relationships between pairs of complex traits from observational studies is of great interest across various scientific domains. However, most existing methods assume the absence of unmeasured confounding and restrict causal…

Methodology · Statistics 2024-07-17 Wei Li , Rui Duan , Sai Li

Ordinal variables, such as on the Likert scale, are common in applied research. Yet, existing methods for causal inference tend to target nominal or continuous data. When applied to ordinal data, this fails to account for the inherent…

Methodology · Statistics 2025-02-26 Martina Scauda , Jack Kuipers , Giusi Moffa

Causality is a subject of philosophical debate and a central scientific issue with a long history. In the statistical domain, the study of cause and effect based on the notion of `fairness' in comparisons dates back several hundred years,…

Other Statistics · Statistics 2022-04-06 Erica EM Moodie , David A Stephens

No man is an island, as individuals interact and influence one another daily in our society. When social influence takes place in experiments on a population of interconnected individuals, the treatment on a unit may affect the outcomes of…

Methodology · Statistics 2017-08-30 Edward K. Kao

The task of causal representation learning aims to uncover latent higher-level causal variables that affect lower-level observations. Identifying the true latent causal variables from observed data, while allowing instantaneous causal…

Machine Learning · Computer Science 2026-02-19 Yuhang Liu , Zhen Zhang , Dong Gong , Mingming Gong , Biwei Huang , Anton van den Hengel , Kun Zhang , Javen Qinfeng Shi

Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in…

Machine Learning · Statistics 2017-10-31 Dustin Tran , David M. Blei

Causal inference with interference is a rapidly growing area. The literature has begun to relax the "no-interference" assumption that the treatment received by one individual does not affect the outcomes of other individuals. In this paper…

Methodology · Statistics 2015-03-06 Tyler J. VanderWeele , Eric J. Tchetgen Tchetgen , M. Elizabeth Halloran

We focus on causal inference for longitudinal treatments, where units are assigned to treatments at multiple time points, aiming to assess the effect of different treatment sequences on an outcome observed at a final point. A common…

Methodology · Statistics 2019-05-14 Federico Ricciardi , Alessandra Mattei , Fabrizia Mealli

Latent or unobserved phenomena pose a significant difficulty in data analysis as they induce complicated and confounding dependencies among a collection of observed variables. Factor analysis is a prominent multivariate statistical modeling…

Methodology · Statistics 2020-06-22 Armeen Taeb , Venkat Chandrasekaran

Causal discovery algorithms allow for the inference of causal structures from probabilistic relations of random variables. A natural field for the application of this tool is quantum mechanics, where a long-standing debate about the role of…

Quantum Physics · Physics 2018-04-19 R. Rossi

Causal inference is a study of causal relationships between events and the statistical study of inferring these relationships through interventions and other statistical techniques. Causal reasoning is any line of work toward determining…

Software Engineering · Computer Science 2023-04-03 Patrick Chadbourne , Nasir Eisty

Randomized experiments on a network often involve interference between connected units; i.e., a situation in which an individual's treatment can affect the response of another individual. Current approaches to deal with interference, in…

Methodology · Statistics 2017-05-17 Guillaume Basse , Edoardo Airoldi

Causal structure learning with data from multiple contexts carries both opportunities and challenges. Opportunities arise from considering shared and context-specific causal graphs enabling to generalize and transfer causal knowledge across…

Machine Learning · Computer Science 2024-10-29 Martin Rabel , Wiebke Günther , Jakob Runge , Andreas Gerhardus

Over the past two decades, considerable strides have been made in advancing neuroscientific techniques, yet challenges remain in attributing causality to observed associations. This review addresses a fundamental issue in observational…

Other Quantitative Biology · Quantitative Biology 2025-11-04 Eric W. Bridgeford , Brian S. Caffo , Maya B. Mathur , Russell A. Poldrack

There has been much recent, exciting work on combining the complementary strengths of latent variable models and deep learning. Latent variable modeling makes it easy to explicitly specify model constraints through conditional independence…

Computation and Language · Computer Science 2019-08-06 Yoon Kim , Sam Wiseman , Alexander M. Rush

Causal models with unobserved variables impose nontrivial constraints on the distributions over the observed variables. When a common cause of two variables is unobserved, it is impossible to uncover the causal relation between them without…

Statistics Theory · Mathematics 2021-12-14 Beata Zjawin , Elie Wolfe , Robert W. Spekkens

The instrumental variables (IVs) method is a leading empirical strategy for causal inference. Finding IVs is a heuristic and creative process, and justifying its validity -- especially exclusion restrictions -- is largely rhetorical. We…

Econometrics · Economics 2025-06-06 Sukjin Han

Detecting and measuring confounding effects from data is a key challenge in causal inference. Existing methods frequently assume causal sufficiency, disregarding the presence of unobserved confounding variables. Causal sufficiency is both…

Artificial Intelligence · Computer Science 2024-09-27 Abbavaram Gowtham Reddy , Vineeth N Balasubramanian