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Graph Neural Networks have emerged as an effective machine learning tool for multi-disciplinary tasks such as pharmaceutical molecule classification and chemical reaction prediction, because they can model non-euclidean relationships…

Machine Learning · Computer Science 2023-07-27 Tongya Zheng , Tianli Zhang , Qingzheng Guan , Wenjie Huang , Zunlei Feng , Mingli Song , Chun Chen

Using the probabilistic language of conditional expectations we reformulate the force matching method for coarse-graining of molecular systems as a projection on spaces of coarse observables. A practical outcome of this probabilistic…

Numerical Analysis · Mathematics 2015-04-10 Evangelia Kalligiannaki , Vagelis Harmandaris , Markos A. Katsoulakis , Petr Plechac

Coarse-Graining (CG) models are low resolution approximation of high resolution models, such as all-atomic (AA) models. An effective CG model is expected to reproduce equilibrium values of sufficient physical quantities of its AA model,…

Statistical Mechanics · Physics 2015-02-10 Shijing Lu , Xin Zhou

A major current challenge poses the systematic construction of coarse-grained models that are dynamically consistent, and, moreover, might be used for systems driven out of thermal equilibrium. Here we present a novel prescription that…

Statistical Mechanics · Physics 2016-08-05 Fabian Knoch , Thomas Speck

We introduce an RG-inspired coarse-graining for extracting the collective features of data. The key to successful coarse-graining lies in finding appropriate pairs of data sets. We coarse-grain the two closest data in a regular real-space…

Data Analysis, Statistics and Probability · Physics 2023-07-19 Jonathan Landy , Tsvi Tlusty , YeongKyu Lee , YongSeok Jho

Coarse-grained (CG) modeling has gained significant attention in recent years due to its wide applicability in enhancing the spatiotemporal scales of molecular simulations. While CG simulations, often performed with Hamiltonian mechanics,…

Chemical Physics · Physics 2025-04-01 Jaehyeok Jin , Gregory A. Voth

Machine-learned force fields have generated significant interest in recent years as a tool for molecular dynamics (MD) simulations, with the aim of developing accurate and efficient models that can replace classical interatomic potentials.…

Machine Learning · Computer Science 2023-04-05 Shaswat Mohanty , Sanghyuk Yoo , Keonwook Kang , Wei Cai

Constructing atom-resolved states from low-resolution data is of practical importance in many areas of science and engineering. This problem is addressed in this paper in the context of multiscale factorization methods for molecular…

Computational Physics · Physics 2016-04-14 Andrew Abi Mansour , Peter J. Ortoleva

Constructing transferable descriptors for conformation representation of molecular and biological systems finds numerous applications in drug discovery, learning-based molecular dynamics, and protein mechanism analysis. Geometric graph…

Machine Learning · Computer Science 2024-10-30 Zihan Pengmei , Zhengyuan Shen , Zichen Wang , Marcus Collins , Huzefa Rangwala

We investigate fundamental connections between thermodynamics and quantum information theory. First, we show that the operational framework of thermal operations is nonequivalent to the framework of Gibbs-preserving maps, and we comment on…

Quantum Physics · Physics 2016-07-13 Philippe Faist

Can complex engineered and biological networks be coarse-grained into smaller and more understandable versions in which each node represents an entire pattern in the original network? To address this, we define coarse-graining units (CGU)…

Molecular Networks · Quantitative Biology 2009-11-10 Shalev Itzkovitz , Reuven Levitt , Nadav Kashtan , Ron Milo , Michael Itzkovitz , Uri Alon

An accurate force field is the key to the success of all molecular mechanics simulations on organic polymers and biomolecules. Accuracy beyond density functional theory is often needed to describe the intermolecular interactions, while most…

Chemical Physics · Physics 2021-08-13 Xufei Wang , Yuanda Xu , Han Zheng , Kuang Yu

A coarse-grained model is developed to allow large-scale molecular dynamics (MD) simulations of a branched polyetherimide derived from two backbone monomers [4,4'-bisphenol A dianhydride (BPADA) and m-phenylenediamine (MPD)], a chain…

Materials Science · Physics 2021-01-15 Chengyuan Wen , Roy Odle , Shengfeng Cheng

In order to understand the physical processes of nanopore experiments at the molecular level, microscopic information from molecular dynamics is greatly needed. Coarse-grained models are a good alternative to classical all-atom models since…

Soft Condensed Matter · Physics 2025-10-16 Delphine Dessaux , Jérôme Mathé , Rosa Ramirez , Nathalie Basdevant

Interpretable Graph Neural Networks (GNNs) aim to reveal the underlying reasoning behind model predictions, attributing their decisions to specific subgraphs that are informative. However, existing subgraph-based interpretable methods…

Machine Learning · Computer Science 2025-05-02 Jie Yang , Yuwen Wang , Kaixuan Chen , Tongya Zheng , Yihe Zhou , Zhenbang Xiao , Ji Cao , Mingli Song , Shunyu Liu

We present a novel thermodynamically guided, low-noise, time-scale bridging, and pertinently efficient strategy for the dynamic simulation of microscopic models for complex fluids. The systematic coarse-graining method is exemplified for…

Soft Condensed Matter · Physics 2010-11-12 Patrick Ilg , Hans Christian Öttinger , Martin Kröger

General circulation models (GCMs) typically have a grid size of 25--200 km. Parametrizations are used to represent diabatic processes such as radiative transfer and cloud microphysics and account for sub-grid-scale motions and variability.…

Atmospheric and Oceanic Physics · Physics 2019-10-23 Noah D Brenowitz , Christopher S Bretherton

In this paper we are interested in the studying coarse-graining in field theories using the language of quantum open systems. Motivated by the ideas of Calzetta and Hu on correlation histories we employ the Zwanzig projection technique to…

High Energy Physics - Theory · Physics 2009-10-30 C. Anastopoulos

Fine-grained classification models are designed to focus on the relevant details necessary to distinguish highly similar classes, particularly when intra-class variance is high and inter-class variance is low. Most existing models rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Riccardo La Grassa , Ignazio Gallo , Nicola Landro

Complex networks can model a range of different systems, from the human brain to social connections. Some of those networks have a large number of nodes and links, making it impractical to analyze them directly. One strategy to simplify…

Disordered Systems and Neural Networks · Physics 2023-04-06 Matheus de C. Loures , Alan Albert Piovesana , José Antônio Brum