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Large Language Models (LLMs) are increasingly being explored for clinical question answering and decision support, yet safe deployment critically requires reliable handling of patient measurements in heterogeneous clinical notes. Existing…

Computation and Language · Computer Science 2026-04-16 Minh-Vuong Nguyen , Fatemeh Shiri , Zhuang Li , Karin Verspoor

Although large language models (LLMs) have been assessed for general medical knowledge using licensing exams, their ability to support clinical decision-making, such as selecting medical calculators, remains uncertain. We assessed nine…

Computation and Language · Computer Science 2025-03-25 Nicholas Wan , Qiao Jin , Joey Chan , Guangzhi Xiong , Serina Applebaum , Aidan Gilson , Reid McMurry , R. Andrew Taylor , Aidong Zhang , Qingyu Chen , Zhiyong Lu

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

Current vision-language models (VLMs) in medicine are primarily designed for categorical question answering (e.g., "Is this normal or abnormal?") or qualitative descriptive tasks. However, clinical decision-making often relies on…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Yongcheng Yao , Yongshuo Zong , Raman Dutt , Yongxin Yang , Sotirios A Tsaftaris , Timothy Hospedales

Large Language Models (LLMs) have emerged as transformative tools in the healthcare sector, demonstrating remarkable capabilities in natural language understanding and generation. However, their proficiency in numerical reasoning,…

Artificial Intelligence · Computer Science 2025-01-27 Arjun R. Malghan

While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to…

Recent advances in vision-language models (VLMs) have achieved remarkable performance on standard medical benchmarks, yet their true clinical reasoning ability remains unclear. Existing datasets predominantly emphasize classification…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Miao Jing , Mengting Jia , Junling Lin , Zhongxia Shen , Huan Gao , Mingkun Xu , Shangyang Li

Existing benchmarks for evaluating the clinical reasoning capabilities of large language models (LLMs) often lack a clear definition of "clinical reasoning" as a construct, fail to capture the full breadth of interdependent tasks within a…

Large Language Models (LLMs) hold great promise to revolutionize current clinical systems for their superior capacities on medical text processing tasks and medical licensing exams. Meanwhile, traditional ML models such as SVM and XGBoost…

Computation and Language · Computer Science 2024-11-12 Canyu Chen , Jian Yu , Shan Chen , Che Liu , Zhongwei Wan , Danielle Bitterman , Fei Wang , Kai Shu

Medical question answering (QA) benchmarks often focus on multiple-choice or fact-based tasks, leaving open-ended answers to real patient questions underexplored. This gap is particularly critical in mental health, where patient questions…

Computation and Language · Computer Science 2026-05-15 Yahan Li , Jifan Yao , John Bosco S. Bunyi , Adam C. Frank , Angel Hsing-Chi Hwang , Ruishan Liu

Large-scale language models (LLMs) often offer clinical judgments based on incomplete information, increasing the risk of misdiagnosis. Existing studies have primarily evaluated confidence in single-turn, static settings, overlooking the…

Computation and Language · Computer Science 2026-01-23 Zhiyao Ren , Yibing Zhan , Siyuan Liang , Guozheng Ma , Baosheng Yu , Dacheng Tao

Medical concept extraction from electronic health records underpins many downstream applications, yet remains challenging because medically meaningful concepts are frequently implied rather than explicitly stated in medical narratives.…

Computation and Language · Computer Science 2026-05-21 Zhichao Yang , Gregory D. Lyng , Sanjit Singh Batra , Robert E. Tillman

Medical calculators are fundamental to quantitative, evidence-based clinical practice. However, their real-world use is an adaptive, multi-stage process, requiring proactive EHR data acquisition, scenario-dependent calculator selection, and…

Artificial Intelligence · Computer Science 2026-02-02 Yakun Zhu , Yutong Huang , Shengqian Qin , Zhongzhen Huang , Shaoting Zhang , Xiaofan Zhang

Large Language Models (LLMs) have shown impressive performance on existing medical question-answering benchmarks. This high performance makes it increasingly difficult to meaningfully evaluate and differentiate advanced methods. We present…

Computation and Language · Computer Science 2025-03-21 Xiangru Tang , Daniel Shao , Jiwoong Sohn , Jiapeng Chen , Jiayi Zhang , Jinyu Xiang , Fang Wu , Yilun Zhao , Chenglin Wu , Wenqi Shi , Arman Cohan , Mark Gerstein

The application of the Multi-modal Large Language Models (MLLMs) in medical clinical scenarios remains underexplored. Previous benchmarks only focus on the capacity of the MLLMs in medical visual question-answering (VQA) or report…

Computation and Language · Computer Science 2024-08-19 Hongcheng Liu , Yusheng Liao , Siqv Ou , Yuhao Wang , Heyang Liu , Yanfeng Wang , Yu Wang

Large language models (LLMs) have demonstrated significant potential in advancing various fields of research and society. However, the current community of LLMs overly focuses on benchmarks for analyzing specific foundational skills (e.g.…

The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensuring accuracy, safety, and ethical alignment. Existing frameworks inadequately dissect domain-specific…

Computation and Language · Computer Science 2025-03-11 Luyi Jiang , Jiayuan Chen , Lu Lu , Xinwei Peng , Lihao Liu , Junjun He , Jie Xu

Large language models (LLMs) show increasing potential in education, yet benchmarks for non-English languages in specialized domains remain scarce. We introduce MedBench-IT, the first comprehensive benchmark for evaluating LLMs on Italian…

Computation and Language · Computer Science 2025-09-10 Ruggero Marino Lazzaroni , Alessandro Angioi , Michelangelo Puliga , Davide Sanna , Roberto Marras

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li