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Cardiac digital twins (CDTs) have the potential to offer individualized evaluation of cardiac function in a non-invasive manner, making them a promising approach for personalized diagnosis and treatment planning of my-ocardial infarction…

Signal Processing · Electrical Eng. & Systems 2024-02-16 Lei Li , Julia Camps , Zhinuo , Wang , Abhirup Banerjee , Marcel Beetz , Blanca Rodriguez , Vicente Grau

Cardiac digital twins (CDTs) of human cardiac electrophysiology (EP) are digital replicas of patient hearts that match like-for-like clinical observations. The electrocardiogram (ECG), as the most prevalent non-invasive observation of…

Medical Physics · Physics 2024-07-26 Elena Zappon , Matthias A. F. Gsell , Karli Gillette , Gernot Plank

Heart diseases rank among the leading causes of global mortality, demonstrating a crucial need for early diagnosis and intervention. Most traditional electrocardiogram (ECG) based automated diagnosis methods are trained at population level,…

Machine Learning · Computer Science 2024-05-14 Yaojun Hu , Jintai Chen , Lianting Hu , Dantong Li , Jiahuan Yan , Haochao Ying , Huiying Liang , Jian Wu

Digital twins for cardiac electrophysiology are an enabling technology for precision cardiology. Current forward models are advanced enough to simulate the cardiac electric activity under different pathophysiological conditions and…

Optimization and Control · Mathematics 2025-05-05 Thomas Grandits , Karli Gillette , Gernot Plank , Simone Pezzuto

A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinning, where the computational mesh of the digital twin is…

This work addresses the inverse problem of electrocardiography from a new perspective, by combining electrical and mechanical measurements. Our strategy relies on the defini-tion of a model of the electromechanical contraction which is…

Numerical Analysis · Mathematics 2015-03-24 Cesare Corrado , Jean-Frédéric Gerbeau , Philippe Moireau

Cardiac digital twins are computational tools capturing key functional and anatomical characteristics of patient hearts for investigating disease phenotypes and predicting responses to therapy. When paired with large-scale computational…

Computational Engineering, Finance, and Science · Computer Science 2024-01-19 Julia Camps , Zhinuo Jenny Wang , Ruben Doste , Maxx Holmes , Brodie Lawson , Jakub Tomek , Kevin Burrage , Alfonso Bueno-Orovio , Blanca Rodriguez

The emergence of deep learning has significantly enhanced the analysis of electrocardiograms (ECGs), a non-invasive method that is essential for assessing heart health. Despite the complexity of ECG interpretation, advanced deep learning…

Machine Learning · Computer Science 2023-06-05 Zibin Zhao

The electrocardiogram (ECG) is a vital tool for diagnosing heart diseases. However, many disease patterns are derived from outdated datasets and traditional stepwise algorithms with limited accuracy. This study presents a method for direct…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Oğuzhan Büyüksolak , İlkay Öksüz

Human digital twins (HDTs) are dynamic, data-driven virtual representations of individuals, continuously updated with multimodal data to simulate, monitor, and predict health trajectories. By integrating clinical, physiological, behavioral,…

Human-Computer Interaction · Computer Science 2025-08-19 Rong Pan , Hongyue Sun , Xiaoyu Chen , Giulia Pedrielli , Jiapeng Huang

The electrocardiogram (ECG) remains a fundamental tool in cardiac diagnostics, yet its interpretation traditionally reliant on the expertise of cardiologists. The emergence of deep learning has heralded a revolutionary era in medical data…

Signal Processing · Electrical Eng. & Systems 2024-09-13 Cheng Ding , Tianliang Yao , Chenwei Wu , Jianyuan Ni

The subject of this thesis is in the area of Applied Mathematics known as Inverse Problems. Inverse problems are those where a set of measured data is analysed in order to get as much information as possible on a model which is assumed to…

Mathematical Physics · Physics 2009-12-03 Andrea A. Almasy

Cardiac digital twins (CDTs) offer personalized in-silico cardiac representations for the inference of multi-scale properties tied to cardiac mechanisms. The creation of CDTs requires precise information about the electrode position on the…

Image and Video Processing · Electrical Eng. & Systems 2025-02-26 Lei Li , Hannah Smith , Yilin Lyu , Julia Camps , Shuang Qian , Blanca Rodriguez , Abhirup Banerjee , Vicente Grau

Background and Objective: Precise preoperative planning and effective physician training for coronary interventions are increasingly important. Despite advances in medical imaging technologies, transforming static or limited dynamic imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Shuo Wang , Tong Ren , Nan Cheng , Rong Wang , Li Zhang

Recently, significant efforts have been made to create Health Digital Twins (HDTs), digital twins for clinical applications. Heart modeling is one of the fastest-growing fields, which favors the effective application of HDTs. The clinical…

Neurons and Cognition · Quantitative Biology 2024-03-21 Zofia Rudnicka , Klaudia Proniewska , Mark Perkins , Agnieszka Pregowska

The rapid developments in advanced sensing and imaging bring about a data-rich environment, facilitating the effective modeling, monitoring, and control of complex systems. For example, the body-sensor network captures multi-channel…

Machine Learning · Computer Science 2022-02-01 Jianxin Xie , Bing Yao

Cardiac digital twins (CDTs) provide personalized in-silico cardiac representations and hold great potential for precision medicine in cardiology. However, whole-heart CDT models that simulate the full organ-scale electromechanics of all…

Image and Video Processing · Electrical Eng. & Systems 2025-07-22 Xiaoyue Liu , Xicheng Sheng , Xiahai Zhuang , Vicente Grau , Mark YY Chan , Ching-Hui Sia , Lei Li

Electrocardiograms (ECGs) are an established technique to screen for abnormal cardiac signals. Recent work has established that it is possible to detect arrhythmia directly from the ECG signal using deep learning algorithms. While a few…

Signal Processing · Electrical Eng. & Systems 2024-11-28 Hyewon Jeong , Suyeol Yun , Hammaad Adam

Digital twin technology has is anticipated to transform healthcare, enabling personalized medicines and support, earlier diagnoses, simulated treatment outcomes, and optimized surgical plans. Digital twins are readily gaining traction in…

Machine Learning · Computer Science 2023-07-12 Logan Nye

Cardiac arrest is one of the biggest global health problems, and early identification and management are key to enhancing the patient's prognosis. In this paper, we propose a novel framework that combines an EfficientNet-based deep learning…

Machine Learning · Computer Science 2025-09-10 Qasim Zia , Avais Jan , Zafar Iqbal , Muhammad Mumtaz Ali , Mukarram Ali , Murray Patterson
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