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A large effort is devoted to the research of new computing paradigms associated to innovative nanotechnologies that should complement and/or propose alternative solutions to the classical Von Neumann/CMOS association. Among various…

Mesoscale and Nanoscale Physics · Physics 2012-02-09 F. Alibart , S. Pleutin , O. Bichler , C. Gamrat , T. Serrano-Gotarredona , B. Linares-Barranco , D. Vuillaume

The distinct timescales of synaptic plasticity and neural activity dynamics play an important role in the brain's learning and memory systems. Activity-dependent plasticity reshapes neural circuit architecture, determining spontaneous and…

Neurons and Cognition · Quantitative Biology 2023-06-30 Heather L Cihak , Zachary P Kilpatrick

Synaptic transmission must balance the need for reliable signalling against the metabolic cost of achieving that reliability. How energetic constraints shape synaptic precision and its regulation during plasticity remains unclear. Here we…

Neurons and Cognition · Quantitative Biology 2026-02-18 James Malkin , Cian O'Donnell , Conor Houghton

We study the synchronization of two model neurons coupled through a synapse having an activity-dependent strength. Our synapse follows the rules of Spike-Timing Dependent Plasticity (STDP). We show that this plasticity of the coupling…

Biological Physics · Physics 2009-11-07 Valentin P. Zhigulin , Mikhail I. Rabinovich , Ramon Huerta , Henry D. I. Abarbanel

Short-term synaptic plasticity (STP) is often regarded as a presynaptic filter of spikes, independent of postsynaptic activity. Recent experiments, however, indicate an associative STP that depends on pre- and postsynaptic coactivation. We…

Neurons and Cognition · Quantitative Biology 2026-05-20 Genki Shimizu , Taro Toyoizumi

Recent studies have proposed that the diffusion of messenger molecules, such as monoamines, can mediate the plastic adaptation of synapses in supervised learning of neural networks. Based on these findings we developed a model for neural…

Neurons and Cognition · Quantitative Biology 2017-09-21 Damian L. Berger , Lucilla de Arcangelis , Hans J. Herrmann

Fluidic iontronics is emerging as a distinctive platform for implementing neuromorphic circuits, characterized by its reliance on the same aqueous medium and ionic signal carriers as the brain. Drawing upon recent theoretical advancements…

Soft Condensed Matter · Physics 2024-06-03 T. M. Kamsma , E. A. Rossing , C. Spitoni , R. van Roij

Dendritic spines, the carriers of long-term memory, occupy a small fraction of cortical space, and yet they are the major consumers of brain metabolic energy. What fraction of this energy goes for synaptic plasticity, correlated with…

Neurons and Cognition · Quantitative Biology 2019-10-17 Jan Karbowski

Biological neural networks do not only include long-term memory and weight multiplication capabilities, as commonly assumed in artificial neural networks, but also more complex functions such as short-term memory, short-term plasticity, and…

In neuroscience, synaptic plasticity refers to the set of mechanisms driving the dynamics of neuronal connections, called synapses and represented by a scalar value, the synaptic weight. A Spike-Timing Dependent Plasticity (STDP) rule is a…

Probability · Mathematics 2021-11-17 Philippe Robert , Gaetan Vignoud

While surrogate backpropagation proves useful for training deep spiking neural networks (SNNs), incorporating biologically inspired local signals on a large scale remains challenging. This difficulty stems primarily from the high memory…

Neural and Evolutionary Computing · Computer Science 2025-12-09 Yuchen Tian , Samuel Tensingh , Jason Eshraghian , Nhan Duy Truong , Omid Kavehei

Brain-inspired learning models attempt to mimic the cortical architecture and computations performed in the neurons and synapses constituting the human brain to achieve its efficiency in cognitive tasks. In this work, we present…

Neural and Evolutionary Computing · Computer Science 2017-03-21 Priyadarshini Panda , Gopalakrishnan Srinivasan , Kaushik Roy

Artificial synapse is a key element of future brain-inspired neuromorphic computing systems implemented in hardware. This work presents a graphene synaptic transistor based on all-technology-compatible materials that exhibits highly tunable…

Future neuromorphic architectures will require millions of artificial synapses, making understanding the physical mechanisms behind their plasticity functionalities mandatory. In this work, we propose a simplified spin memristor, where the…

Applied Physics · Physics 2024-09-13 J. O. Castro , B. Buyatti , D. Mercado , A. Di Donato , M. Quintero , M. Tortarolo

Reconfigurable memristors featuring neural and synaptic functions hold great potential for neuromorphic circuits by simplifying system architecture, cutting power consumption, and boosting computational efficiency. Their additive…

Bayesian inference provides a principled framework for understanding brain function, while neural activity in the brain is inherently spike-based. This paper bridges these two perspectives by designing spiking neural networks that simulate…

Neurons and Cognition · Quantitative Biology 2026-01-01 Sepideh Adamiat , Wouter M. Kouw , Bert de Vries

The demand for computing power has been growing exponentially with the rise of artificial intelligence (AI), machine learning, and the Internet of Things (IoT). This growth requires unconventional computing primitives that prioritize energy…

Brain-inspired learning mechanisms, e.g. spike timing dependent plasticity (STDP), enable agile and fast on-the-fly adaptation capability in a spiking neural network. When incorporating emerging nanoscale resistive non-volatile memory (NVM)…

Neural and Evolutionary Computing · Computer Science 2020-02-19 Xinyu Wu , Vishal Saxena

The endeavor to understand the brain involves multiple collaborating research fields. Classically, synaptic plasticity rules derived by theoretical neuroscientists are evaluated in isolation on pattern classification tasks. This contrasts…

Unlike conventional two-dimensional (2D) semiconductor superlattices, moir\'{e} patterns in 2D materials are flexible and their electronic, magnetic, optical, and mechanical properties depend on their topography. Within a…

Mesoscale and Nanoscale Physics · Physics 2022-11-07 Alexandre Artaud , Nicolas Rougemaille , Sergio Vlaic , Vincent T. Renard , Nicolae Atodiresei , Johann Coraux