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Randomisation is used in experimental design to reduce the prevalence of unanticipated confounders. Complete randomisation can however create unbalanced designs, for example, grouping all samples of the same condition in the same batch.…

Quantitative Methods · Quantitative Biology 2020-07-14 Bram Burger , Marc Vaudel , Harald Barsnes

We propose a new model selection criterion for mixed effects regression models that is computable when the model is fitted with a two-step method, even when the structure and the distribution of the random effects are unknown. The criterion…

Methodology · Statistics 2018-03-14 Radu V. Craiu , Thierry Duchesne

This study combines simulated annealing with delta evaluation to solve the joint stratification and sample allocation problem. In this problem, atomic strata are partitioned into mutually exclusive and collectively exhaustive strata. Each…

Artificial Intelligence · Computer Science 2021-11-23 Mervyn O'Luing , Steven Prestwich , S. Armagan Tarim

Many policy evaluations occur in settings where treatment is randomized at the cluster level, and there is treatment noncompliance within each cluster. For example, villages might be assigned to treatment and control, but residents in each…

Methodology · Statistics 2019-08-16 Hyunseung Kang , Luke Keele

Statistical inference on the explained variation of an outcome by a set of covariates is of particular interest in practice. When the covariates are of moderate to high-dimension and the effects are not sparse, several approaches have been…

Methodology · Statistics 2022-01-24 Hua Yun Chen

Model-based clustering defines population level clusters relative to a model that embeds notions of similarity. Algorithms tailored to such models yield estimated clusters with a clear statistical interpretation. We take this view here and…

Methodology · Statistics 2018-12-14 Florentina Bunea , Christophe Giraud , Xi Luo , Martin Royer , Nicolas Verzelen

Effect size estimates are thought to capture the collective, two-way response to an intervention or exposure in a three-way problem among the intervention/exposure, various confounders and the outcome. For meaningful causal inference from…

Methodology · Statistics 2024-02-08 Orestis Loukas , Ho Ryun Chung

Clustered data arise naturally in many scientific and applied research settings where units are grouped within clusters. They are commonly analyzed using linear mixed models to account for within-cluster correlations. This article focuses…

Methodology · Statistics 2025-10-10 Zhi Yang Tho , Raymond Chambers , A. H. Welsh

Inferring the causal effect of a treatment on an outcome in an observational study requires adjusting for observed baseline confounders to avoid bias. However, adjusting for all observed baseline covariates, when only a subset are…

Methodology · Statistics 2021-02-04 Wen Wei Loh , Stijn Vansteelandt

Clustering is widely used for unsupervised structure discovery, yet it offers limited insight into how reliable each individual assignment is. Diagnostics, such as convergence behavior or objective values, may reflect global quality, but…

Machine Learning · Computer Science 2026-05-15 Aggelos Semoglou , John Pavlopoulos

In randomized experiments, the actual treatments received by some experimental units may differ from their treatment assignments. This non-compliance issue often occurs in clinical trials, social experiments, and the applications of…

Methodology · Statistics 2022-04-19 Jiyang Ren

Triple Differences (DDD) designs are widely used in empirical work to relax parallel trends assumptions in Difference-in-Differences (DiD) settings. This paper highlights that common DDD implementations -- such as taking the difference…

Econometrics · Economics 2025-07-21 Marcelo Ortiz-Villavicencio , Pedro H. C. Sant'Anna

The study of multi-task learning has drawn great attention from the community. Despite the remarkable progress, the challenge of optimally learning different tasks simultaneously remains to be explored. Previous works attempt to modify the…

Computer Vision and Pattern Recognition · Computer Science 2022-03-08 Yuanze Li , Yiwen Guo , Qizhang Li , Hongzhi Zhang , Wangmeng Zuo

For experiments running in field plots or over time, the observations are often correlated due to spatial or serial correlation, which leads to correlated errors in a linear model analyzing the treatment means. Without knowing the exact…

Methodology · Statistics 2016-05-30 Rena K. Mann , Roderick Edwards , Julie Zhou

We consider how increasingly available observational data can be used to improve the design of randomized controlled trials (RCTs). We seek to design a prospective RCT, with the intent of using an Empirical Bayes estimator to shrink the…

Methodology · Statistics 2022-04-15 Evan T. R. Rosenman , Luke Miratrix

Unmeasured confounding presents a common challenge in observational studies, potentially making standard causal parameters unidentifiable without additional assumptions. Given the increasing availability of diverse data sources, exploiting…

Methodology · Statistics 2023-09-18 Shanshan Luo , Yechi Zhang , Wei Li

Cluster-randomized trials (CRTs) are widely used to evaluate group-level interventions and increasingly collect multiple outcomes capturing complementary dimensions of benefit and risk. Investigators often seek a single global summary of…

Methodology · Statistics 2026-01-22 Xinyuan Chen , Fan Li

Given covariates for $n$ units, each of which is to receive a treatment with probability $1/2$, we study the question of how best to correlate their treatment assignments to minimize the variance of the IPW estimator of the average…

Methodology · Statistics 2025-01-08 Tim Morrison , Art B. Owen

This article develops design-based ratio estimators for clustered, blocked randomized controlled trials (RCTs), with an application to a federally funded, school-based RCT testing the effects of behavioral health interventions. We consider…

Methodology · Statistics 2024-05-31 Peter Z. Schochet , Nicole E. Pashley , Luke W. Miratrix , Tim Kautz

A/B testing is a standard approach for evaluating the effect of online experiments; the goal is to estimate the `average treatment effect' of a new feature or condition by exposing a sample of the overall population to it. A drawback with…

Social and Information Networks · Computer Science 2013-05-31 Johan Ugander , Brian Karrer , Lars Backstrom , Jon Kleinberg
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