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Foundation models in artificial intelligence (AI) are transforming medical imaging by enabling general-purpose feature learning from large-scale, unlabeled datasets. In this work, we introduce BrainFound, a self-supervised foundation model…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Moona Mazher , Geoff J. M. Parker , Daniel C. Alexander

We present a keypoint-based foundation model for general purpose brain MRI registration, based on the recently-proposed KeyMorph framework. Our model, called BrainMorph, serves as a tool that supports multi-modal, pairwise, and scalable…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Alan Q. Wang , Rachit Saluja , Heejong Kim , Xinzi He , Adrian Dalca , Mert R. Sabuncu

Magnetic resonance imaging (MRI) is critically important for brain mapping in both scientific research and clinical studies. Precise segmentation of brain tumors facilitates clinical diagnosis, evaluations, and surgical planning. Deep…

Image and Video Processing · Electrical Eng. & Systems 2023-05-01 Rui Nian , Guoyao Zhang , Yao Sui , Yuqi Qian , Qiuying Li , Mingzhang Zhao , Jianhui Li , Ali Gholipour , Simon K. Warfield

Foundation models (FMs), large neural networks pretrained on extensive and diverse datasets, have revolutionized artificial intelligence and shown significant promise in medical imaging by enabling robust performance with limited labeled…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Salah Ghamizi , Georgia Kanli , Yu Deng , Magali Perquin , Olivier Keunen

Multimodal learning, especially large-scale multimodal pre-training, has developed rapidly over the past few years and led to the greatest advances in artificial intelligence (AI). Despite its effectiveness, understanding the underlying…

Neural and Evolutionary Computing · Computer Science 2022-08-18 Haoyu Lu , Qiongyi Zhou , Nanyi Fei , Zhiwu Lu , Mingyu Ding , Jingyuan Wen , Changde Du , Xin Zhao , Hao Sun , Huiguang He , Ji-Rong Wen

Developing Foundation Models for medical image analysis is essential to overcome the unique challenges of radiological tasks. The first challenges of this kind for 3D brain MRI, SSL3D and FOMO25, were held at MICCAI 2025. Our solution…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Pedro M. Gordaliza , Jaume Banus , Benoît Gérin , Maxence Wynen , Nataliia Molchanova , Jonas Richiardi , Meritxell Bach Cuadra

Brain foundation models (BFMs) have emerged as a transformative paradigm in computational neuroscience, offering a revolutionary framework for processing diverse neural signals across different brain-related tasks. These models leverage…

Machine Learning · Computer Science 2025-07-22 Xinliang Zhou , Chenyu Liu , Zhisheng Chen , Kun Wang , Yi Ding , Ziyu Jia , Qingsong Wen

Transfer learning has gained attention in medical image analysis due to limited annotated 3D medical datasets for training data-driven deep learning models in the real world. Existing 3D-based methods have transferred the pre-trained models…

Computer Vision and Pattern Recognition · Computer Science 2021-04-29 Eunji Jun , Seungwoo Jeong , Da-Woon Heo , Heung-Il Suk

Multi-modal MR imaging is routinely used in clinical practice to diagnose and investigate brain tumors by providing rich complementary information. Previous multi-modal MRI segmentation methods usually perform modal fusion by concatenating…

Image and Video Processing · Electrical Eng. & Systems 2022-09-01 Zhaohu Xing , Lequan Yu , Liang Wan , Tong Han , Lei Zhu

Whole-brain parcellation from MRI is a critical yet challenging task due to the complexity of subdividing the brain into numerous small, irregular shaped regions. Traditionally, template-registration methods were used, but recent advances…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Yucheng Li , Xiaofan Wang , Junyi Wang , Yijie Li , Xi Zhu , Mubai Du , Dian Sheng , Wei Zhang , Fan Zhang

Foundation models are transforming neuroscience but are often prohibitively large, data-hungry, and difficult to deploy. Here, we introduce BrainSymphony, a lightweight and parameter-efficient foundation model with plug-and-play integration…

Quantitative Methods · Quantitative Biology 2026-02-13 Moein Khajehnejad , Forough Habibollahi , Devon Stoliker , Adeel Razi

Understanding how the brain represents visual information is a fundamental challenge in neuroscience and artificial intelligence. While AI-driven decoding of neural data has provided insights into the human visual system, integrating…

Neural and Evolutionary Computing · Computer Science 2025-10-07 Dongyang Li , Haoyang Qin , Mingyang Wu , Chen Wei , Quanying Liu

We present Brain Harmony (BrainHarmonix), the first multimodal brain foundation model that unifies structural morphology and functional dynamics into compact 1D token representations. The model was pretrained on two of the largest…

The segmentation of substantial brain lesions is a significant and challenging task in the field of medical image segmentation. Substantial brain lesions in brain imaging exhibit high heterogeneity, with indistinct boundaries between lesion…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Hongming Wang , Yifeng Wu , Huimin Huang , Hongtao Wu , Jia-Xuan Jiang , Xiaodong Zhang , Hao Zheng , Xian Wu , Yefeng Zheng , Jinping Xu , Jing Cheng

Understanding and predicting the progression of neurodegenerative diseases remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning. However, most available…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Nivetha Jayakumar , Swakshar Deb , Bahram Jafrasteh , Qingyu Zhao , Miaomiao Zhang

3D structural Magnetic Resonance Imaging (MRI) brain scans are commonly acquired in clinical settings to monitor a wide range of neurological conditions, including neurodegenerative disorders and stroke. While deep learning models have…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Emily Kaczmarek , Justin Szeto , Brennan Nichyporuk , Tal Arbel

Medical images used in clinical practice are heterogeneous and not the same quality as scans studied in academic research. Preprocessing breaks down in extreme cases when anatomy, artifacts, or imaging parameters are unusual or protocols…

Image and Video Processing · Electrical Eng. & Systems 2022-08-31 Mostafa Mehdipour Ghazi , Mads Nielsen

Accurate brain tumor segmentation from Magnetic Resonance Imaging (MRI) is desirable to joint learning of multimodal images. However, in clinical practice, it is not always possible to acquire a complete set of MRIs, and the problem of…

Image and Video Processing · Electrical Eng. & Systems 2022-08-05 Yao Zhang , Nanjun He , Jiawei Yang , Yuexiang Li , Dong Wei , Yawen Huang , Yang Zhang , Zhiqiang He , Yefeng Zheng

Medical image challenges have played a transformative role in advancing the field, catalyzing innovation and establishing new performance benchmarks. Image registration, a foundational task in neuroimaging, has similarly advanced through…

Brain Tumor Segmentation (BraTS) plays a critical role in clinical diagnosis, treatment planning, and monitoring the progression of brain tumors. However, due to the variability in tumor appearance, size, and intensity across different MRI…

Image and Video Processing · Electrical Eng. & Systems 2024-09-19 Hongjun Zhu , Jiaohang Huang , Kuo Chen , Xuehui Ying , Ying Qian
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