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The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested that the resulting correlations among amino acid compositions at different…

At the crossway of machine learning and data analysis, anomaly detection aims at identifying observations that exhibit abnormal behaviour. Be it measurement errors, disease development, severe weather, production quality default(s) (items)…

Methodology · Statistics 2025-06-06 Romain Valla , Pavlo Mozharovskyi , Florence d'Alché-Buc

In the Shannon lecture at the 2019 International Symposium on Information Theory (ISIT), Ar{\i}kan proposed to employ a one-to-one convolutional transform as a pre-coding step before the polar transform. The resulting codes of this…

Information Theory · Computer Science 2024-01-19 Mohammad Rowshan , Andreas Burg , Emanuele Viterbo

In this paper, we present a method to mine object-part patterns from conv-layers of a pre-trained convolutional neural network (CNN). The mined object-part patterns are organized by an And-Or graph (AOG). This interpretable AOG…

Computer Vision and Pattern Recognition · Computer Science 2018-12-20 Quanshi Zhang , Ruiming Cao , Ying Nian Wu , Song-Chun Zhu

Open-Set Classification (OSC) intends to adapt closed-set classification models to real-world scenarios, where the classifier must correctly label samples of known classes while rejecting previously unseen unknown samples. Only recently,…

Computer Vision and Pattern Recognition · Computer Science 2022-10-19 Andres Palechor , Annesha Bhoumik , Manuel Günther

Software design is crucial to successful software development, yet is a demanding multi-objective problem for software engineers. In an attempt to assist the software designer, interactive (i.e. human in-the-loop) meta-heuristic search…

Software Engineering · Computer Science 2014-06-24 Christopher L. Simons , Jim Smith , Paul White

A large number of protein sequences are becoming available through the application of novel high-throughput sequencing technologies. Experimental functional characterization of these proteins is time-consuming and expensive, and is often…

Genomics · Quantitative Biology 2017-09-28 Maxat Kulmanov , Mohammed Asif Khan , Robert Hoehndorf

Attributed Graph Clustering (AGC) is a fundamental unsupervised task that partitions nodes into cohesive groups by jointly modeling structural topology and node attributes. While the advent of graph neural networks and self-supervised…

Machine Learning · Computer Science 2026-03-24 Yunhui Liu , Yue Liu , Yongchao Liu , Tao Zheng , Stan Z. Li , Xinwang Liu , Tieke He

Purpose: This study aimed to enhance protein sequence classification using natural language processing (NLP) techniques while addressing the impact of sequence similarity on model performance. We compared various machine learning and deep…

Quantitative Methods · Quantitative Biology 2025-05-26 Huma Perveen , Julie Weeds

This paper describes the software implementation of genetic algorithm for identifying and selecting most relevant results received during sequentially executed subject search operations. Simulated evolutionary process generates sustainable…

Information Retrieval · Computer Science 2015-04-17 V. K. Ivanov , P. I. Meskin

Open set classification (OSC) tackles the problem of determining whether the data are in-class or out-of-class during inference, when only provided with a set of in-class examples at training time. Traditional OSC methods usually train…

Machine Learning · Computer Science 2020-08-12 Yang Yang , Zhen-Qiang Sun , Hui Xiong , Jian Yang

This paper performs comprehensive analysis on datasets for occlusion-aware face segmentation, a task that is crucial for many downstream applications. The collection and annotation of such datasets are time-consuming and labor-intensive.…

Computer Vision and Pattern Recognition · Computer Science 2022-05-13 Kenny T. R. Voo , Liming Jiang , Chen Change Loy

We introduce EvoFlows, a variable-length protein sequence-to-sequence modeling approach designed for protein engineering. Existing protein language models are poorly suited for optimization tasks: autoregressive models require full sequence…

Machine Learning · Computer Science 2026-04-09 Nicolas Deutschmann , Constance Ferragu , Jonathan D. Ziegler , Shayan Aziznejad , Eli Bixby

Models of codon evolution are commonly used to identify positive selection. Positive selection is typically a heterogeneous process, i.e., it acts on some branches of the evolutionary tree and not others. Previous work on DNA models showed…

Populations and Evolution · Quantitative Biology 2017-09-18 Michael D. Woodhams , Jeremy G. Sumner , David A. Liberles , Michael A. Charleston , Barbara R. Holland

Stochastic reaction networks are mathematical models with a wide range of applications in biochemistry, ecology, and epidemiology, and are often complex to analyze. Except for some special cases, it is generally difficult to predict how the…

Probability · Mathematics 2026-04-02 Daniele Cappelletti , Giulio Cuniberti , Paola Siri

Standard Occupational Classifiers (SOC) are systems used to categorize and classify different types of jobs and occupations based on their similarities in terms of job duties, skills, and qualifications. Integrating these facets with Big…

Computation and Language · Computer Science 2025-12-01 Sidharth Rony , Jack Patman

Survival analysis concerns the task of predicting the time until an event occurs. Often used in the medical field, survival analysis deals with incomplete (i.e., censored) data, for instance, from patients who did not experience the event…

Machine Learning · Computer Science 2026-05-29 Thalea Schlender , Peter A. N. Bosman , Tanja Alderliesten

Deep clustering aims to learn a clustering representation through deep architectures. Most of the existing methods usually conduct clustering with the unique goal of maximizing clustering performance, that ignores the personalized demand of…

Computer Vision and Pattern Recognition · Computer Science 2022-11-02 Mengdie Wang , Liyuan Shang , Suyun Zhao , Yiming Wang , Hong Chen , Cuiping Li , Xizhao Wang

Large language models struggle with understanding codebases beyond a certain scale -- repositories with hundreds of thousands of lines of code. Existing methods -- retrieval, summarization, agent exploration -- each construct a different…

Software Engineering · Computer Science 2026-05-05 Jinshi Liu , Hanying Zuo , Congyin Cao , Anran Zhang , Yixuan Liu , Xinzhou Xie

The automation and digitalization of business processes has resulted in large amounts of data captured in information systems, which can aid businesses in understanding their processes better, improve workflows, or provide operational…

Artificial Intelligence · Computer Science 2022-07-21 Timo Rohrer , Anahita Farhang Ghahfarokhi , Mohamed Behery , Gerhard Lakemeyer , Wil M. P. van der Aalst
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