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Strongly supervised learning requires detailed knowledge of truth labels at instance levels, and in many machine learning applications this is a major drawback. Multiple instance learning (MIL) is a popular weakly supervised learning method…

Machine Learning · Computer Science 2022-02-18 Saul Fuster , Trygve Eftestøl , Kjersti Engan

Although significant progress achieved, multi-label classification is still challenging due to the complexity of correlations among different labels. Furthermore, modeling the relationships between input and some (dull) classes further…

Computer Vision and Pattern Recognition · Computer Science 2020-08-18 Junbing Li , Changqing Zhang , Pengfei Zhu , Baoyuan Wu , Lei Chen , Qinghua Hu

This paper addresses the challenges posed by the unstructured nature and high-dimensional semantic complexity of electronic health record texts. A deep learning method based on attention mechanisms is proposed to achieve unified modeling…

Computation and Language · Computer Science 2025-07-03 Ting Xu , Xiaoxiao Deng , Xiandong Meng , Haifeng Yang , Yan Wu

Computational pathology models that use digitized histopathology whole-slide images have the potential to become a cost-effective and scalable alternative to molecular assays for the prediction of genomic biomarkers, a key task in precision…

Quantitative Methods · Quantitative Biology 2026-03-03 Ekaterina Redekop , Eric Zimmermann , Ava P Amini , Alex X Lu , Neil Tenenholtz , James Brian Hall , Lorin Crawford , Kristen A Severson

Detection and differentiation of circulating tumor cells (CTCs) and non-CTCs in blood draws of cancer patients pose multiple challenges. While the gold standard relies on tedious manual evaluation of an automatically generated selection of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Hümeyra Husseini-Wüsthoff , Sabine Riethdorf , Andreas Schneeweiss , Andreas Trumpp , Klaus Pantel , Harriet Wikman , Maximilian Nielsen , René Werner

Multiple instance learning (MIL) is a variation of supervised learning where a single class label is assigned to a bag of instances. In this paper, we state the MIL problem as learning the Bernoulli distribution of the bag label where the…

Machine Learning · Computer Science 2018-06-29 Maximilian Ilse , Jakub M. Tomczak , Max Welling

Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide…

Class-incremental learning (CIL) for endoscopic image analysis is crucial for real-world clinical applications, where diagnostic models should continuously adapt to evolving clinical data while retaining performance on previously learned…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Bingrong Liu , Jun Shi , Yushan Zheng

Multiple instance learning (MIL) is the preferred approach for whole slide image classification. However, most MIL approaches do not exploit the interdependencies of tiles extracted from a whole slide image, which could provide valuable…

Computer Vision and Pattern Recognition · Computer Science 2021-08-26 Marvin Lerousseau , Maria Vakalopoulou , Eric Deutsch , Nikos Paragios

Multimodal multilabel classification (MMC) is a challenging task that aims to design a learning algorithm to handle two data sources, the image and text, and learn a comprehensive semantic feature presentation across the modalities. In this…

Computer Vision and Pattern Recognition · Computer Science 2024-06-25 Yanming Guo

In several supervised learning scenarios, auxiliary losses are used in order to introduce additional information or constraints into the supervised learning objective. For instance, knowledge distillation aims to mimic outputs of a powerful…

Machine Learning · Computer Science 2022-12-08 Durga Sivasubramanian , Ayush Maheshwari , Pradeep Shenoy , Prathosh AP , Ganesh Ramakrishnan

Multiple Instance Learning (MIL) plays a significant role in computational pathology, enabling weakly supervised analysis of Whole Slide Image (WSI) datasets. The field of WSI analysis is confronted with a severe long-tailed distribution…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xitong Ling , Yifeng Ping , Jiawen Li , Jing Peng , Yuxuan Chen , Minxi Ouyang , Yizhi Wang , Yonghong He , Tian Guan , Xiaoping Liu , Lianghui Zhu

The complexities inherent to leukemia, multifaceted cancer affecting white blood cells, pose considerable diagnostic and treatment challenges, primarily due to reliance on laborious morphological analyses and expert judgment that are…

Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide.Multi-modal MRI data is crucial for accurate brain tumor segmentation, but missing modalities common in clinical practice can severely…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Bingcang Huang , Kai Chen , Lin Gu , Zhe Wang , Sai Wu , Chang Yao

The rapid evolution of artificial intelligence in drug discovery encounters challenges with generalization and extensive training, yet Large Language Models (LLMs) offer promise in reshaping interactions with complex molecular data. Our…

Biomolecules · Quantitative Biology 2024-12-20 He Cao , Zijing Liu , Xingyu Lu , Yuan Yao , Yu Li

Novelty detection plays an important role in machine learning and signal processing. This paper studies novelty detection in a new setting where the data object is represented as a bag of instances and associated with multiple class labels,…

Machine Learning · Computer Science 2013-12-02 Qi Lou , Raviv Raich , Forrest Briggs , Xiaoli Z. Fern

Image recognition techniques heavily rely on abundant labeled data, particularly in medical contexts. Addressing the challenges associated with obtaining labeled data has led to the prominence of self-supervised learning and semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Hao Feng , Yuanzhe Jia , Ruijia Xu , Mukesh Prasad , Ali Anaissi , Ali Braytee

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

In histopathology, intelligent diagnosis of Whole Slide Images (WSIs) is essential for automating and objectifying diagnoses, reducing the workload of pathologists. However, diagnostic models often face the challenge of forgetting…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Weixi Zheng , Aoling Huang , Jingping Yuan , Haoyu Zhao , Zhou Zhao , Yongchao Xu , Thierry Géraud

Machine learning components commonly appear in larger decision-making pipelines; however, the model training process typically focuses only on a loss that measures accuracy between predicted values and ground truth values. Decision-focused…

Machine Learning · Computer Science 2019-07-19 Aaron Ferber , Bryan Wilder , Bistra Dilkina , Milind Tambe
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