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Drug-drug interactions (DDIs) strongly affect the safety and efficacy of combination therapies. Despite the availability of large DDI databases, selecting optimal multi-drug combinations that balance safety, therapeutic benefit, and regimen…

Quantum Physics · Physics 2026-01-27 Mai Nguyen Phuong Nhi , Lan Nguyen Tran , Le Bin Ho

Variational quantum algorithms have been advocated as promising candidates to solve combinatorial optimization problems on near-term quantum computers. Their methodology involves transforming the optimization problem into a quadratic…

Quantum Physics · Physics 2023-08-01 Zoé Verchère , Sourour Elloumi , Andrea Simonetto

In this paper, we propose a quantum algorithm that supports a real-valued higher-order unconstrained binary optimization (HUBO) problem. This algorithm is based on the Grover adaptive search that originally supported HUBO with integer…

Signal Processing · Electrical Eng. & Systems 2023-02-17 Masaya Norimoto , Ryuhei Mori , Naoki Ishikawa

A quantum-inspired optimization approach is proposed to study the portfolio optimization aimed at selecting an optimal mix of assets based on the risk-return trade-off to achieve the desired goal in investment. By integrating conventional…

Portfolio Management · Quantitative Finance 2024-11-15 Ying-Chang Lu , Chao-Ming Fu , Lien-Po Yu , Yen-Jui Chang , Ching-Ray Chang

Optimization of constrained quantum control problems powers quantum technologies. This task becomes very difficult when these control problems are nonconvex and plagued with dense local extrema. For such problems current optimization…

This paper proposes a novel combination of constraint encoding methods for the Quantum Approximate Optimization Ansatz (QAOA). Real-world optimization problems typically consist of multiple types of constraints. To solve these optimization…

Quantum control is concerned with the realisation of desired dynamics in quantum systems, serving as a linchpin for advancing quantum technologies and fundamental research. Analytic approaches and standard optimisation algorithms do not…

Quantum Physics · Physics 2025-05-29 Jan Ole Ernst , Aniket Chatterjee , Tim Franzmeyer , Axel Kuhn

We present Quafu-Qcover, an open-source cloud-based software package designed for combinatorial optimization problems that support both quantum simulators and hardware backends. Quafu-Qcover provides a standardized and complete workflow for…

Quantum Physics · Physics 2023-05-30 BAQIS Quafu Group

As power systems expand, solving the Unit Commitment Problem (UCP) becomes increasingly challenging due to the dimensional catastrophe, and traditional methods often struggle to balance computational efficiency and solution quality. To…

Systems and Control · Electrical Eng. & Systems 2025-03-27 Jingxian Zhou , Ziqing Zhu , Linghua Zhu , Siqi Bu

We propose and implement a family of quantum-informed recursive optimization (QIRO) algorithms for combinatorial optimization problems. Our approach leverages quantum resources to obtain information that is used in problem-specific…

The Quadratic Unconstrained Binary Optimization (QUBO) modeling and solution framework is a requirement for quantum and digital annealers. However optimality for QUBO problems of any practical size is extremely difficult to achieve. In…

Artificial Intelligence · Computer Science 2021-05-13 Amit Verma , Mark Lewis

Optimization problems are critical across various domains, yet existing quantum algorithms, despite their great potential, struggle with scalability and accuracy due to excessive reliance on entanglement. To address these limitations, we…

Quantum Physics · Physics 2025-03-04 Seongmin Kim , In-Saeng Suh

We propose an approach to quantum computing in which quantum gate strengths are parametrized by quantum degrees of freedom, and the capability of the quantum computer to perform desired tasks is monitored and gradually improved by…

Quantum Physics · Physics 2009-11-25 Soren Gammelmark , Klaus Molmer

Variational quantum algorithms (VQAs) represent a promising approach to utilizing current quantum computing infrastructures. VQAs are based on a parameterized quantum circuit optimized in a closed loop via a classical algorithm. This hybrid…

Quantum Physics · Physics 2024-04-10 David Fitzek , Robert S. Jonsson , Werner Dobrautz , Christian Schäfer

Feedback control protocols can stabilize and enhance the operation of quantum devices, however, unavoidable delays in the feedback loop adversely affect their performance. We introduce a quantum control methodology, combining open-loop…

Quantum Physics · Physics 2010-03-25 Joshua Combes , Howard M. Wiseman , A. J. Scott

The Quantum Approximate Optimization Algorithm (QAOA) requires considered optimization problems to be translated into a compatible format. A popular transformation step in this pipeline involves the quadratization of higher-order binary…

Quantum Physics · Physics 2025-11-26 Damian Rovara , Lukas Burgholzer , Robert Wille

In the era of quantum computing, the emergence of quantum computers and subsequent advancements have led to the development of various quantum algorithms capable of solving linear equations and eigenvalues, surpassing the pace of classical…

Quantum Physics · Physics 2024-11-26 Hyunju Lee , Kyungtaek Jun

This paper proposes a hybrid quantum-classical algorithm to solve a fundamental power system problem called unit commitment (UC). The UC problem is decomposed into a quadratic subproblem, a quadratic unconstrained binary optimization (QUBO)…

Quantum Physics · Physics 2022-04-19 Reza Mahroo , Amin Kargarian

Gaussian Processes are used in many applications to model spatial phenomena. Within this context, a key issue is to decide the set of locations where to take measurements so as to obtain a better approximation of the underlying function.…

Emerging Technologies · Computer Science 2019-01-31 Lorenzo Bottarelli , Alessandro Farinelli

We propose a simple feedback-control scheme for adiabatic quantum computation with superconducting flux qubits. The proposed method makes use of existing on-chip hardware to monitor the ground-state curvature, which is then used to control…

Quantum Physics · Physics 2013-01-04 R. D. Wilson , A. M. Zagoskin , S. Savel'ev , M. J. Everitt , Franco Nori
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