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The Quantum Approximate Optimization Algorithm (QAOA) constitutes one of the often mentioned candidates expected to yield a quantum boost in the era of near-term quantum computing. In practice, quantum optimization will have to compete with…

Quantum Physics · Physics 2020-10-15 Charles Moussa , Henri Calandra , Vedran Dunjko

The Quantum Approximate Optimization Algorithm (QAOA) was originally developed to solve combinatorial optimization problems, but has become a standard for assessing the performance of quantum computers. Fully descriptive benchmarking…

Quantum Physics · Physics 2024-02-29 Anthony M. Polloreno , Graeme Smith

Quantum optimization solvers typically rely on one-variable-to-one-qubit mapping. However, the low qubit count on current quantum computers is a major obstacle in competing against classical methods. Here, we develop a qubit-efficient…

Quantum Physics · Physics 2026-03-24 Bhuvanesh Sundar , Maxime Dupont

The quantum approximate optimization algorithm (QAOA) applies two Hamiltonians to a quantum system in alternation. The original goal of the algorithm was to drive the system close to the ground state of one of the Hamiltonians. This paper…

Quantum Physics · Physics 2018-12-31 Seth Lloyd

The quantum approximate optimization algorithm (QAOA) is known for its capability and universality in solving combinatorial optimization problems on near-term quantum devices. The results yielded by QAOA depend strongly on its initial…

Quantum Physics · Physics 2022-09-29 Xinwei Lee , Ningyi Xie , Yoshiyuki Saito , Dongsheng Cai , Nobuyoshi Asai

The Quantum Approximate Optimization Algorithm (QAOA) is a hybrid quantum-classical algorithm to solve binary-variable optimization problems. Due to the short circuit depth and its expected robustness to systematic errors, it is one of the…

Quantum Physics · Physics 2022-08-23 Jason Larkin , Matías Jonsson , Daniel Justice , Gian Giacomo Guerreschi

Many quantum algorithms seek to output a specific bitstring solving the problem of interest--or a few if the solution is degenerate. It is the case for the quantum approximate optimization algorithm (QAOA) in the limit of large circuit…

Quantum Physics · Physics 2022-08-23 Maxime Dupont , Nicolas Didier , Mark J. Hodson , Joel E. Moore , Matthew J. Reagor

We establish and discuss a number of connections between a digitized version of Quantum Annealing (QA) with the Quantum Approximate Optimization Algorithm (QAOA) introduced by Farhi et al. (arXiv:1411.4028) as an alternative hybrid…

Quantum Physics · Physics 2019-12-10 Glen Bigan Mbeng , Rosario Fazio , Giuseppe Santoro

An enhanced framework of quantum approximate optimization algorithm (QAOA) is introduced and the parameter setting strategies are analyzed. The enhanced QAOA is as effective as the QAOA but exhibits greater computing power and flexibility,…

Quantum Physics · Physics 2020-12-18 Mingyou Wu , Zhihao Liu , Hanwu Chen

Quantum variational algorithms have garnered significant interest recently, due to their feasibility of being implemented and tested on noisy intermediate scale quantum (NISQ) devices. We examine the robustness of the quantum approximate…

Quantum Physics · Physics 2019-11-05 Yulong Dong , Xiang Meng , Lin Lin , Robert Kosut , K. Birgitta Whaley

Quantum Approximation Optimization Algorithm (QAOA) is a highly advocated variational algorithm for solving the combinatorial optimization problem. One critical feature in the quantum circuit of QAOA algorithm is that it consists of…

Quantum Physics · Physics 2022-07-21 Yuwei Jin , Jason Luo , Lucent Fong , Yanhao Chen , Ari B. Hayes , Chi Zhang , Fei Hua , Eddy Z. Zhang

The quantum approximate optimization algorithm (QAOA) is a leading iterative variational quantum algorithm for heuristically solving combinatorial optimization problems. A large portion of the computational effort in QAOA is spent by the…

Quantum Physics · Physics 2022-08-23 Ohad Amosy , Tamuz Danzig , Ely Porat , Gal Chechik , Adi Makmal

The quantum approximate optimisation ansatz (QAOA) is one of the flagship algorithms used to tackle combinatorial optimisation on graphs problems using a quantum computer, and is considered a strong candidate for early fault-tolerant…

Quantum Physics · Physics 2025-06-24 Yann Beaujeault-Taudière

Quantum Approximate Optimization Algorithm (QAOA) is one of the most promising quantum heuristics for combinatorial optimization. While QAOA has been shown to perform well on small-scale instances and to provide an asymptotic speedup over…

The quantum approximate optimization algorithm (QAOA) is a method of approximately solving combinatorial optimization problems. While QAOA is developed to solve a broad class of combinatorial optimization problems, it is not clear which…

Quantum Physics · Physics 2020-08-13 James Ostrowski , Rebekah Herrman , Travis S. Humble , George Siopsis

The Quantum Approximate Optimization Algorithm (QAOA) is a leading candidate for demonstrating quantum advantage on near-term devices, yet the physical origins of its efficacy remain poorly understood. In this work, we study QAOA for random…

Quantum Physics · Physics 2026-05-21 Mingyou Wu , Hanwu Chen

Molecular docking is a critical process for drug discovery and challenging due to the complexity and size of biomolecular systems, where the optimal binding configuration of a drug to a target protein is determined. Hybrid classical-quantum…

Emerging Technologies · Computer Science 2025-03-07 Christos Papalitsas , Yanfei Guan , Shreyas Waghe , Athanasios Liakos , Ioannis Balatsos , Vassilios Pantazopoulos

Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

The Quantum Approximate Optimisation Algorithm (QAOA) is a widely studied quantum-classical iterative heuristic for combinatorial optimisation. While QAOA targets problems in complexity class NP, the classical optimisation procedure…

Quantum Physics · Physics 2025-11-12 Tom Krüger , Wolfgang Mauerer

Quantum computing has the potential to improve our ability to solve certain optimization problems that are computationally difficult for classical computers, by offering new algorithmic approaches that may provide speedups under specific…

Quantum Physics · Physics 2025-04-24 Ilya Tyagin , Marwa H. Farag , Kyle Sherbert , Karunya Shirali , Yuri Alexeev , Ilya Safro
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