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Microwell microfluidics has been utilized for single-cell analysis to reveal heterogeneity in gene expression, signaling pathways, and phenotypic responses for identifying rare cell types, understanding disease progression, and developing…

Neurons and Cognition · Quantitative Biology 2025-10-17 Dinh-Nguyen Nguyen , Sadia Shakil , Raymond Kai-Yu Tong , Ngoc-Duy Dinh

Large Language Models (LLMs) have recently made significant advances in code generation through the 'Chain-of-Thought' prompting technique. This technique empowers the model to autonomously devise "solution plans" to tackle intricate…

Software Engineering · Computer Science 2024-03-21 Zhihong Sun , Chen Lyu , Bolun Li , Yao Wan , Hongyu Zhang , Ge Li , Zhi Jin

Efficiently reranking documents retrieved from information retrieval (IR) pipelines to enhance overall quality of Retrieval-Augmented Generation (RAG) system remains an important yet challenging problem. Recent studies have highlighted the…

Computation and Language · Computer Science 2025-11-12 Jingyu Wu , Aditya Shrivastava , Jing Zhu , Alfy Samuel , Anoop Kumar , Daben Liu

The increase in open-source availability of Large Language Models (LLMs) has enabled users to deploy them on more and more resource-constrained edge devices to reduce reliance on network connections and provide more privacy. However, the…

Hardware Architecture · Computer Science 2024-08-02 Jude Haris , Rappy Saha , Wenhao Hu , José Cano

Goal-oriented de novo molecule design, namely generating molecules with specific property or substructure constraints, is a crucial yet challenging task in drug discovery. Existing methods, such as Bayesian optimization and reinforcement…

Computational Engineering, Finance, and Science · Computer Science 2025-02-28 Chuanliu Fan , Ziqiang Cao , Zicheng Ma , Nan Yu , Yimin Peng , Jun Zhang , Yiqin Gao , Guohong Fu

Large Language Models (LLMs) have achieved remarkable success across a wide range of natural language tasks, and recent efforts have sought to extend their capabilities to multimodal domains and resource-constrained environments. However,…

Machine Learning · Computer Science 2025-05-26 Yun-Da Tsai

With the rapid growth of large language models (LLMs), a wide range of methods have been developed to distribute computation and memory across hardware devices for efficient training and inference. While existing surveys provide descriptive…

Machine Learning · Computer Science 2026-02-11 Hossam Amer , Rezaul Karim , Ali Pourranjbar , Weiwei Zhang , Walid Ahmed , Boxing Chen

Large Language Models (LLMs) and other large foundation models have achieved noteworthy success, but their size exacerbates existing resource consumption and latency challenges. In particular, the large-scale deployment of these models is…

Machine Learning · Computer Science 2023-08-30 Banghua Zhu , Ying Sheng , Lianmin Zheng , Clark Barrett , Michael I. Jordan , Jiantao Jiao

Large Language Models (LLMs) have recently demonstrated impressive capabilities across various real-world applications. However, due to the current text-in-text-out paradigm, it remains challenging for LLMs to handle dynamic and complex…

Artificial Intelligence · Computer Science 2024-10-25 Timothy Wei , Annabelle Miin , Anastasia Miin

While Large Language Models (LLMs) have achieved remarkable success in various fields, the efficiency of training and inference remains a major challenge. To address this issue, we propose SUBLLM, short for Subsampling-Upsampling-Bypass…

Computation and Language · Computer Science 2024-08-26 Quandong Wang , Yuxuan Yuan , Xiaoyu Yang , Ruike Zhang , Kang Zhao , Wei Liu , Jian Luan , Daniel Povey , Bin Wang

Traditional approaches for designing analog circuits are time-consuming and require significant human expertise. Existing automation efforts using methods like Bayesian Optimization (BO) and Reinforcement Learning (RL) are sub-optimal and…

Machine Learning · Computer Science 2025-06-06 Dimple Vijay Kochar , Hanrui Wang , Anantha Chandrakasan , Xin Zhang

Recently, large language models (LLMs) have achieved huge success in the natural language processing (NLP) field, driving a growing demand to extend their deployment from the cloud to edge devices. However, deploying LLMs on…

Hardware Architecture · Computer Science 2025-05-08 Yanbiao Liang , Huihong Shi , Haikuo Shao , Zhongfeng Wang

Low-rank and sparse composite approximation is a natural idea to compress Large Language Models (LLMs). However, such an idea faces two primary challenges that adversely affect the performance of existing methods. The first challenge…

Machine Learning · Computer Science 2026-02-27 Changhai Zhou , Qian Qiao , Yuhua Zhou , Yuxin Wu , Shichao Weng , Weizhong Zhang , Cheng Jin

Recurrent neural networks (RNNs) serve as a fundamental building block for many sequence tasks across natural language processing. Recent research has focused on recurrent dropout techniques or custom RNN cells in order to improve…

Computation and Language · Computer Science 2017-08-04 Stephen Merity , Bryan McCann , Richard Socher

Despite the remarkable success of large language models (LLMs) on traditional natural language processing tasks, their planning ability remains a critical bottleneck in tackling complex multi-step reasoning tasks. Existing approaches mainly…

Computation and Language · Computer Science 2024-10-07 Jiaxin Wen , Jian Guan , Hongning Wang , Wei Wu , Minlie Huang

Inspired by the recent success of large language models (LLMs) like ChatGPT, researchers start to explore the adoption of LLMs for agile hardware design, such as generating design RTL based on natural-language instructions. However, in…

Machine Learning · Computer Science 2023-11-14 Yao Lu , Shang Liu , Qijun Zhang , Zhiyao Xie

Automated unit test generation is critical for software quality but traditional structure-driven methods often lack the semantic understanding required to produce realistic inputs and oracles. Large language models (LLMs) address this…

Software Engineering · Computer Science 2026-01-01 Bei Chu , Yang Feng , Kui Liu , Zhaoqiang Guo , Yichi Zhang , Hange Shi , Zifan Nan , Baowen Xu

Dramatic increases in the capabilities of neural network models in recent years are driven by scaling model size, training data, and corresponding computational resources. To develop the exceedingly large networks required in modern…

Machine Learning · Computer Science 2025-04-15 Jared Fernandez , Luca Wehrstedt , Leonid Shamis , Mostafa Elhoushi , Kalyan Saladi , Yonatan Bisk , Emma Strubell , Jacob Kahn

Designing controllers for complex industrial electronic systems is challenging due to nonlinearities and parameter uncertainties, and traditional methods are often slow and costly. To address this, we propose a novel autonomous design…

Systems and Control · Electrical Eng. & Systems 2025-07-23 Chenggang Cui , Jiaming Liu , Peifeng Hui , Pengfeng Lin , Chuanlin Zhang

This paper presents an integrated framework that combines traditional network optimization models with large language models (LLMs) to deliver interactive, explainable, and role-aware decision support for supply chain planning. The proposed…

Artificial Intelligence · Computer Science 2025-09-01 Saravanan Venkatachalam