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As machine learning becomes increasingly central to molecular design, it is vital to ensure the reliability of learnable protein-ligand scoring functions on novel protein targets. While many scoring functions perform well on standard…

Machine Learning · Computer Science 2025-12-08 Jakub Kopko , David Graber , Saltuk Mustafa Eyrilmez , Stanislav Mazurenko , David Bednar , Jiri Sedlar , Josef Sivic

Test data is said to be out-of-distribution (OOD) when it unexpectedly differs from the training data, a common challenge in real-world use cases of machine learning. Although OOD generalisation has gained interest in recent years, few…

Computation and Language · Computer Science 2024-09-30 Dejan Porjazovski , Anssi Moisio , Mikko Kurimo

A common use of machine learning (ML) models is predicting the class of a sample. Object detection is an extension of classification that includes localization of the object via a bounding box within the sample. Classification, and by…

Machine Learning · Computer Science 2025-08-07 Erin Lanus , Daniel Wolodkin , Laura J. Freeman

Recent advances in machine learning (ML) methods have led to substantial improvement in materials property prediction against community benchmarks, but an excellent benchmark score may not imply good generalization of performance. Here we…

Materials Science · Physics 2023-04-26 Kangming Li , Brian DeCost , Kamal Choudhary , Michael Greenwood , Jason Hattrick-Simpers

To create state-of-the-art models for many downstream tasks, it has become common practice to fine-tune a pre-trained large vision model. However, it remains an open question of how to best determine which of the many possible model…

Machine Learning · Computer Science 2025-12-08 Simon Guiroy , Mats Richter , Sarath Chandar , Christopher Pal

This study explores the application and performance of Transformational Machine Learning (TML) in drug discovery. TML, a meta learning algorithm, excels in exploiting common attributes across various domains, thus developing composite…

Biomolecules · Quantitative Biology 2023-10-02 Adnan Mahmud , Oghenejokpeme Orhobor , Ross D. King

In-context learning (ICL) is now a common method for teaching large language models (LLMs) new tasks: given labeled examples in the input context, the LLM learns to perform the task without weight updates. Do models guided via ICL infer the…

Computation and Language · Computer Science 2024-04-11 Aaron Mueller , Albert Webson , Jackson Petty , Tal Linzen

A key component of automated algorithm selection and configuration, which in most cases are performed using supervised machine learning (ML) methods is a good-performing predictive model. The predictive model uses the feature representation…

Preference learning (PL) with large language models (LLMs) aims to align the LLMs' generations with human preferences. Previous work on reinforcement learning from human feedback (RLHF) has demonstrated promising results in in-distribution…

Machine Learning · Computer Science 2024-06-11 Chen Jia

Data-driven molecular discovery leverages artificial intelligence/machine learning (AI/ML) and generative modeling to filter and design novel molecules. Discovering novel molecules requires accurate out-of-distribution (OOD) predictions,…

Modern quantum machine learning (QML) methods involve variationally optimizing a parameterized quantum circuit on a training data set, and subsequently making predictions on a testing data set (i.e., generalizing). In this work, we provide…

The accurate prediction of material properties is crucial in a wide range of scientific and engineering disciplines. Machine learning (ML) has advanced the state of the art in this field, enabling scientists to discover novel materials and…

Materials Science · Physics 2024-08-20 Qinyang Li , Nicholas Miklaucic , Jianjun Hu

Large-scale transformers achieve impressive results on program synthesis benchmarks, yet their true generalization capabilities remain obscured by data contamination and opaque training corpora. To rigorously assess whether models are truly…

Machine Learning · Computer Science 2026-05-01 Henrik Voigt , Michael Habeck , Joachim Giesen

Recent years have witnessed a fast-growing interest in computing explanations for Machine Learning (ML) models predictions. For non-interpretable ML models, the most commonly used approaches for computing explanations are heuristic in…

Machine Learning · Computer Science 2019-07-05 Alexey Ignatiev , Nina Narodytska , Joao Marques-Silva

Ensembling is among the most popular tools in machine learning (ML) due to its effectiveness in minimizing variance and thus improving generalization. Most ensembling methods for black-box base learners fall under the umbrella of "stacked…

Machine Learning · Computer Science 2025-12-17 Hilaf Hasson , Danielle C. Maddix , Yuyang Wang , Gaurav Gupta , Youngsuk Park

Reliable generalization lies at the heart of safe ML and AI. However, understanding when and how neural networks generalize remains one of the most important unsolved problems in the field. In this work, we conduct an extensive empirical…

Large language models are increasingly applied to materials science, yet fundamental questions remain about their reliability and knowledge encoding. Evaluating 25 LLMs across four materials science tasks -- over 200 base and fine-tuned…

Materials Science · Physics 2026-03-03 Vineeth Venugopal , Soroush Mahjoubi , Elsa Olivetti

Common designs of model evaluation typically focus on monolingual settings, where different models are compared according to their performance on a single data set that is assumed to be representative of all possible data for the task at…

Computation and Language · Computer Science 2022-04-12 Zoey Liu , Emily Prud'hommeaux

Recent results in image classification and extractive question answering have observed that pre-trained models trained on less in-distribution data have better out-of-distribution performance. However, it is unclear how broadly these trends…

Computation and Language · Computer Science 2023-06-01 Nelson F. Liu , Ananya Kumar , Percy Liang , Robin Jia

Modern deep learning systems do not generalize well when the test data distribution is slightly different to the training data distribution. While much promising work has been accomplished to address this fragility, a systematic study of…