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We consider the problem of efficiently performing simulation and inference for stochastic kinetic models. Whilst it is possible to work directly with the resulting Markov jump process, computational cost can be prohibitive for networks of…

Computation · Statistics 2015-06-18 Chris Sherlock , Andrew Golightly , Colin Gillespie

Markovian jump linear systems (MJLS) are an important class of dynamical systems that arise in many control applications. In this paper, we introduce the problem of controlling unknown (discrete-time) MJLS as a new benchmark for…

Optimization and Control · Mathematics 2020-07-16 Joao Paulo Jansch-Porto , Bin Hu , Geir Dullerud

Modern methods of simulating molecular systems are based on the mathematical theory of Markov operators with a focus on autonomous equilibrated systems. However, non-autonomous physical systems or non-autonomous simulation processes are…

Probability · Mathematics 2020-11-09 Alexander Sikorski , Marcus Weber , Christof Schütte

We investigate the Poisson regression method for Markov and semi-Markov jump processes from a nonparametric angle, allowing the lengths of the time and duration intervals in the partition to vary with the number of observations. Imposing no…

Statistics Theory · Mathematics 2026-05-06 Martin Bladt , Rasmus Frigaard Lemvig

Markov jump processes and continuous time Bayesian networks are important classes of continuous time dynamical systems. In this paper, we tackle the problem of inferring unobserved paths in these models by introducing a fast auxiliary…

Methodology · Statistics 2012-02-20 Vinayak Rao , Yee Whye Teh

We consider continuous time Markovian processes where populations of individual agents interact stochastically according to kinetic rules. Despite the increasing prominence of such models in fields ranging from biology to smart cities,…

Machine Learning · Statistics 2016-05-16 Anastasis Georgoulas , Jane Hillston , Guido Sanguinetti

Discrete diffusion models, like continuous diffusion models, generate high-quality samples by gradually undoing noise applied to datapoints with a Markov process. Gradual generation in theory comes with many conceptual benefits; for…

Machine Learning · Computer Science 2025-09-30 Alan N. Amin , Nate Gruver , Andrew Gordon Wilson

In this work, we study dynamic programming (DP) algorithms for partially observable Markov decision processes with jointly continuous and discrete state-spaces. We consider a class of stochastic systems which have coupled discrete and…

Optimization and Control · Mathematics 2019-03-07 Donghwan Lee , Niao He , Jianghai Hu

Markov jump process models have many applications across science. Often, these models are defined on a state-space of product form and only one of the components of the process is of direct interest. In this paper, we extend the marginal…

Quantitative Methods · Quantitative Biology 2018-06-28 Leo Bronstein , Heinz Koeppl

While deep learning methods have achieved strong performance in time series prediction, their black-box nature and inability to explicitly model underlying stochastic processes often limit their generalization to non-stationary data,…

Machine Learning · Computer Science 2026-02-10 Yuanpei Gao , Qi Yan , Yan Leng , Renjie Liao

Bayesian analysis for Markov jump processes is a non-trivial and challenging problem. Although exact inference is theoretically possible, it is computationally demanding thus its applicability is limited to a small class of problems. In…

Computation · Statistics 2017-02-08 Vassilios Stathopoulos , Mark A. Girolami

The use of stochastic models, in effect piecewise deterministic Markov processes (PDMP), has become increasingly popular especially for the modeling of chemical reactions and cell biophysics. Yet, exact simulation methods, for the…

Numerical Analysis · Mathematics 2015-04-28 Romain Veltz

Consider a system of interacting particles indexed by the nodes of a graph whose vertices are equipped with marks representing parameters of the model such as the environment or initial data. Each particle takes values in a countable state…

Probability · Mathematics 2022-10-18 Ankan Ganguly , Kavita Ramanan

Stochastic thermodynamics investigates energetic and entropic bounds in small systems. Foundational results, e.g., the first and second laws, predominantly rely on the Markov (memoryless) assumption. Although physicists recognise that the…

Statistical Mechanics · Physics 2026-05-12 Kiyoshi Kanazawa , Andreas Dechant

Consider a continuous time particle system $\eta^t=(\eta^t(k),k\in \mathbb{L})$, indexed by a lattice $\mathbb{L}$ which will be either $\mathbb{Z}$, $\mathbb{Z}/n\mathbb{Z}$, a segment $\{1,\cdots, n\}$, or $\mathbb{Z}^d$, and taking its…

Probability · Mathematics 2019-01-11 Luis Fredes , Jean-François Marckert

We discuss in detail how non-Markovian open system dynamics can be described in terms of quantum jumps [J. Piilo et al., Phys. Rev. Lett. 100, 180402 (2008)]. Our results demonstrate that it is possible to have a jump description contained…

Quantum Physics · Physics 2009-06-25 J. Piilo , K. Harkonen , S. Maniscalco , K. -A. Suominen

We describe a generalization of the Hierarchical Dirichlet Process Hidden Markov Model (HDP-HMM) which is able to encode prior information that state transitions are more likely between "nearby" states. This is accomplished by defining a…

Machine Learning · Statistics 2017-07-24 Colin Reimer Dawson , Chaofan Huang , Clayton T. Morrison

We consider a Markov jump process on a general state space to which we apply a time-dependent weak perturbation over a finite time interval. By martingale-based stochastic calculus, under a suitable exponential moment bound for the…

Probability · Mathematics 2024-05-14 Alessandra Faggionato , Vittoria Silvestri

The study of time-inhomogeneous Markov jump processes is a traditional topic within probability theory that has recently attracted substantial attention in various applications. However, their flexibility also incurs a substantial…

Probability · Mathematics 2023-11-03 Martin Bladt , Oscar Peralta

Systems of interacting continuous-time Markov chains are a powerful model class, but inference is typically intractable in high dimensional settings. Auxiliary information, such as noisy observations, is typically only available at discrete…

Machine Learning · Statistics 2026-04-21 Giosue Migliorini , Padhraic Smyth