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Large Language Models (LLMs) have exhibited remarkable capabilities in clinical scenarios. Despite their potential, existing works face challenges when applying LLMs to medical settings. Strategies relying on training with medical datasets…

Computation and Language · Computer Science 2025-10-10 Keer Lu , Zheng Liang , Da Pan , Shusen Zhang , Guosheng Dong , Zhonghai Wu , Huang Leng , Bin Cui , Wentao Zhang

The aim of this paper is to evaluate whether large language models trained on multi-choice question data can be used to discriminate between medical subjects. This is an important and challenging task for automatic question answering. To…

Computation and Language · Computer Science 2024-03-22 Víctor Ponce-López

Large Language Models (LLMs) are increasingly adopted as conversational assistants in genomics, where they are mainly used to reason over biological knowledge, annotations, and analysis outputs through natural language interfaces. However,…

Genomics · Quantitative Biology 2026-04-08 Weicai Long , Yusen Hou , Junning Feng , Houcheng Su , Shuo Yang , Donglin Xie , Yanlin Zhang

The recent success of Large Language Models (LLMs) has had a significant impact on the healthcare field, providing patients with medical advice, diagnostic information, and more. However, due to a lack of professional medical knowledge,…

Computation and Language · Computer Science 2024-06-27 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Xiang Wan , Feng Jiang , Benyou Wang

Large language models (LLMs) are increasingly evident for accurate question answering across various domains. However, rigorous evaluation of their performance on complex question-answering (QA) capabilities is essential before deployment…

Computation and Language · Computer Science 2025-09-03 Reem Abdel-Salam , Mary Adewunmi , Modinat A. Abayomi

Recently, large language model (LLM) based artificial intelligence (AI) systems have demonstrated remarkable capabilities in natural language understanding and generation. However, these models face a significant challenge when it comes to…

The biomedical domain has sparked a significant interest in the field of Natural Language Processing (NLP), which has seen substantial advancements with pre-trained language models (PLMs). However, comparing these models has proven…

Benchmarks establish a standardized evaluation framework to systematically assess the performance of large language models (LLMs), facilitating objective comparisons and driving advancements in the field. However, existing benchmarks fail…

Computation and Language · Computer Science 2026-02-16 Ziqian Zhang , Xingjian Hu , Yue Huang , Kai Zhang , Ruoxi Chen , Yixin Liu , Qingsong Wen , Kaidi Xu , Xiangliang Zhang , Neil Zhenqiang Gong , Lichao Sun

Large language models (LLMs) have demonstrated impressive capabilities in various reasoning tasks but face significant challenges with complex, knowledge-intensive multi-hop queries, particularly those involving new or long-tail knowledge.…

Computation and Language · Computer Science 2025-08-25 Jie He , Nan Hu , Wanqiu Long , Jiaoyan Chen , Jeff Z. Pan

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Open-ended question answering (QA) evaluates a model's ability to perform contextualized reasoning beyond factual recall. This challenge is especially acute in practice-based domains, where knowledge is procedural and grounded in…

Computation and Language · Computer Science 2026-01-29 Si Chen , Le Huy Khiem , Annalisa Szymanski , Ronald Metoyer , Ting Hua , Nitesh V. Chawla

Several studies showed that Large Language Models (LLMs) can answer medical questions correctly, even outperforming the average human score in some medical exams. However, to our knowledge, no study has been conducted to assess the ability…

Computation and Language · Computer Science 2025-01-03 Asma Ben Abacha , Wen-wai Yim , Yujuan Fu , Zhaoyi Sun , Meliha Yetisgen , Fei Xia , Thomas Lin

Most large language models (LLMs) are trained once and never updated; thus, they lack the ability to dynamically adapt to our ever-changing world. In this work, we perform a detailed study of the factuality of LLM-generated text in the…

Computation and Language · Computer Science 2023-11-23 Tu Vu , Mohit Iyyer , Xuezhi Wang , Noah Constant , Jerry Wei , Jason Wei , Chris Tar , Yun-Hsuan Sung , Denny Zhou , Quoc Le , Thang Luong

Multi-entity question answering (MEQA) represents significant challenges for large language models (LLM) and retrieval-augmented generation (RAG) systems, which frequently struggle to consolidate scattered information across diverse…

Computation and Language · Computer Science 2025-09-25 Teng Lin , Yuyu Luo , Honglin Zhang , Jicheng Zhang , Chunlin Liu , Kaishun Wu , Nan Tang

Large language models (LLMs) show promise for healthcare question answering, but clinical use is limited by weak verification, insufficient evidence grounding, and unreliable confidence signalling. We propose a multi-agent medical QA…

Computation and Language · Computer Science 2026-02-17 Naeimeh Nourmohammadi , Md Meem Hossain , The Anh Han , Safina Showkat Ara , Zia Ush Shamszaman

Multimodal/vision language models (VLMs) are increasingly being deployed in healthcare settings worldwide, necessitating robust benchmarks to ensure their safety, efficacy, and fairness. Multiple-choice question and answer (QA) datasets…

Large Language Models (LLMs) have emerged as a potential solution to assist digital health development with patient education, commonly medication-related enquires. We trained and validated Med-Pal, a medication domain-specific LLM-chatbot…

Multi-Turn Long-Form Question Answering (MT-LFQA) is a key application paradigm of Large Language Models (LLMs) in knowledge-intensive domains. However, existing benchmarks are limited to single-turn dialogue, while multi-turn dialogue…

Computation and Language · Computer Science 2025-09-29 Junhao Chen , Yu Huang , Siyuan Li , Rui Yao , Hanqian Li , Hanyu Zhang , Jungang Li , Jian Chen , Bowen Wang , Xuming Hu

We introduce BiMediX2, a bilingual (Arabic-English) Bio-Medical EXpert Large Multimodal Model that supports text-based and image-based medical interactions. It enables multi-turn conversation in Arabic and English and supports diverse…

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie