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Drawing parallels with the way biological networks are studied, we adapt the treatment--control paradigm to explainable artificial intelligence research and enrich it through multi-parametric input alterations. In this study, we propose a…

Machine Learning · Statistics 2026-01-16 Pavel Kharyuk , Sergey Matveev , Ivan Oseledets

Global sensitivity analysis is the main quantitative technique for identifying the most influential input variables in a numerical simulation model. In particular when the inputs are independent, Sobol' sensitivity indices attribute a…

Statistics Theory · Mathematics 2021-01-15 Sébastien da Veiga

The Sobol' indices are a recognized tool in global sensitivity analysis. When the uncertain variables in a model are statistically independent, the Sobol' indices may be easily interpreted and utilized. However, their interpretation and…

Data Analysis, Statistics and Probability · Physics 2018-08-17 Joseph Hart , Pierre Gremaud

Sensitivity analyses reveal the influence of various modeling choices on the outcomes of statistical analyses. While theoretically appealing, they are overwhelmingly inefficient for complex Bayesian models. In this work, we propose…

We derive a novel sensitivity analysis of input variables for predictive epistemic and aleatoric uncertainty. We use Bayesian neural networks with latent variables as a model class and illustrate the usefulness of our sensitivity analysis…

Machine Learning · Statistics 2017-12-12 Stefan Depeweg , José Miguel Hernández-Lobato , Steffen Udluft , Thomas Runkler

Global Sensitivity Analysis (GSA) is the study of the influence of any given inputs on the outputs of a model. In the context of engineering design, GSA has been widely used to understand both individual and collective contributions of…

Machine Learning · Statistics 2024-03-06 Yigitcan Comlek , Liwei Wang , Wei Chen

There exist many methods for sensitivity analysis readily available to the practitioner. While each seeks to help the modeler answer the same general question -- How do sources of uncertainty or changes in the model inputs relate to…

Methodology · Statistics 2025-06-16 Devin Francom , Abigael Nachtsheim

To investigate the robustness of the output probabilities of a Bayesian network, a sensitivity analysis can be performed. A one-way sensitivity analysis establishes, for each of the probability parameters of a network, a function expressing…

Artificial Intelligence · Computer Science 2013-01-18 Uffe Kjærulff , Linda C. van der Gaag

This paper explores the application of active learning strategies to adaptively learn Sobol indices for global sensitivity analysis. We demonstrate that active learning for Sobol indices poses unique challenges due to the definition of the…

Machine Learning · Computer Science 2023-08-29 Mohit Chauhan , Mariel Ojeda-Tuz , Ryan Catarelli , Kurtis Gurley , Dimitrios Tsapetis , Michael D. Shields

The complexity and size of state-of-the-art cell models have significantly increased in part due to the requirement that these models possess complex cellular functions which are thought--but not necessarily proven--to be important. Modern…

Neurons and Cognition · Quantitative Biology 2018-11-22 J. L. Hart , P. A. Gremaud , T. David

Causal inference relies on the untestable assumption of no unmeasured confounding. Sensitivity analysis can be used to quantify the impact of unmeasured confounding on causal estimates. Among sensitivity analysis methods proposed in the…

Methodology · Statistics 2026-03-12 Yushu Zou , Liangyuan Hu , Amanda Ricciuto , Mark Deneau , Kuan Liu

Causal inference with observational studies often suffers from unmeasured confounding, yielding biased estimators based on the unconfoundedness assumption. Sensitivity analysis assesses how the causal conclusions change with respect to…

Methodology · Statistics 2024-04-01 Sizhu Lu , Peng Ding

In this article a novel approach for training deep neural networks using Bayesian techniques is presented. The Bayesian methodology allows for an easy evaluation of model uncertainty and additionally is robust to overfitting. These are…

Machine Learning · Computer Science 2019-04-03 Konstantin Posch , Jürgen Pilz

Global sensitivity analysis is now established as a powerful approach for determining the key random input parameters that drive the uncertainty of model output predictions. Yet the classical computation of the so-called Sobol' indices is…

Computation · Statistics 2016-06-16 L. Le Gratiet , S. Marelli , B. Sudret

Global sensitivity analysis aims at quantifying respective effects of input random variables (or combinations thereof) onto variance of a physical or mathematical model response. Among the abundant literature on sensitivity measures, Sobol'…

Computation · Statistics 2017-05-12 E. Burnaev , I. Panin , B. Sudret

One-dimensional Poincare inequalities are used in Global Sensitivity Analysis (GSA) to provide derivative-based upper bounds and approximations of Sobol indices. We add new perspectives by investigating weighted Poincare inequalities. Our…

Probability · Mathematics 2024-12-09 David Heredia , Aldéric Joulin , Olivier Roustant

In scientific applications, predictive modeling is often of limited use without accurate uncertainty quantification (UQ) to indicate when a model may be extrapolating or when more data needs to be collected. Bayesian Neural Networks (BNNs)…

Machine Learning · Computer Science 2025-09-26 Scott Koermer , Natalie Klein

The PAWN index is gaining traction among the modelling community as a sensitivity measure. However, the robustness to its design parameters has not yet been scrutinized: the size ($N$) and sampling ($\varepsilon$) of the model output, the…

Applications · Statistics 2020-09-03 Arnald Puy , Samuele Lo Piano , Andrea Saltelli

Uncertainties exist in both physics-based and data-driven models. Variance-based sensitivity analysis characterizes how the variance of a model output is propagated from the model inputs. The Sobol index is one of the most widely used…

Methodology · Statistics 2020-06-09 Zhanlin Liu , Youngjun Choe

In this paper we apply a methodology introduced in Navarro Jimenez et al (2016) in the framework of chemical reaction networks to perform a global sensitivity analysis on simulations of a continuous-time Markov chain model motivated by…

Methodology · Statistics 2024-07-26 Henri Mermoz Kouye , Gildas Mazo , Clémentine Prieur , Elisabeta Vergu