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The Gene or DNA sequence in every cell does not control genetic properties on its own; Rather, this is done through translation of DNA into protein and subsequent formation of a certain 3D structure. The biological function of a protein is…

Computational Engineering, Finance, and Science · Computer Science 2019-05-30 Leila Khalatbari , Mohammad Reza Kangavari , Saeid Hosseini , Hongzhi Yin , Ngai-Man Cheung

The quest for accurate prediction of drug molecule properties poses a fundamental challenge in the realm of Artificial Intelligence Drug Discovery (AIDD). An effective representation of drug molecules emerges as a pivotal component in this…

Machine Learning · Computer Science 2024-04-22 Zhuoyuan Wang , Jiacong Mi , Shan Lu , Jieyue He

Multimodal learning typically relies on the assumption that all modalities are fully available during both the training and inference phases. However, in real-world scenarios, consistently acquiring complete multimodal data presents…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Donggeun Kim , Taesup Kim

Substantial advances in multi-modal Artificial Intelligence (AI) facilitate the combination of diverse medical modalities to achieve holistic health assessments. We present COMPRER , a novel multi-modal, multi-objective pretraining…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Guy Lutsker , Hagai Rossman , Nastya Godiva , Eran Segal

Molecular Property Prediction (MPP) is vital for drug discovery, crop protection, and environmental science. Over the last decades, diverse computational techniques have been developed, from using simple physical and chemical properties and…

Machine Learning · Computer Science 2024-04-08 Afnan Sultan , Jochen Sieg , Miriam Mathea , Andrea Volkamer

Machine-learning (ML) models in polymer science typically treat a polymer as a single, perfectly defined molecular graph, even though real materials consist of stochastic ensembles of chains with distributed lengths. This mismatch between…

Machine Learning · Computer Science 2025-12-16 Khalid Ferji

Is there a way for a designer to evaluate the performance of a given hood frame geometry without spending significant time on simulation setup? This paper seeks to address this challenge by developing a multimodal machine-learning (MMML)…

Machine Learning · Computer Science 2025-09-16 Abhishek Indupally , Satchit Ramnath

The discovery of polymers with targeted properties is challenged by the vast chemical design space and the limited availability of consistent, high-quality data across multiple properties. In this work, an integrated polymer informatics…

Chemical Physics · Physics 2026-03-31 Sobin Alosious , Yuhan Liu , Jiaxin Xu , Gang Liu , Renzheng Zhang , Meng Jiang , Tengfei Luo

One of the primary areas of interest in High Performance Computing is the improvement of performance of parallel workloads. Nowadays, compilable source code-based optimization tasks that employ deep learning often exploit LLVM Intermediate…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-07-03 Akash Dutta , Ali Jannesari

Multimodality Representation Learning, as a technique of learning to embed information from different modalities and their correlations, has achieved remarkable success on a variety of applications, such as Visual Question Answering (VQA),…

Artificial Intelligence · Computer Science 2024-03-04 Muhammad Arslan Manzoor , Sarah Albarri , Ziting Xian , Zaiqiao Meng , Preslav Nakov , Shangsong Liang

Recent advancements in computational chemistry have leveraged the power of trans-former-based language models, such as MoLFormer, pre-trained using a vast amount of simplified molecular-input line-entry system (SMILES) sequences, to…

Biomolecules · Quantitative Biology 2024-11-05 Tianhao Peng , Yuchen Li , Xuhong Li , Jiang Bian , Zeke Xie , Ning Sui , Shahid Mumtaz , Yanwu Xu , Linghe Kong , Haoyi Xiong

In recent years, there has been a surge in the development of 3D structure-based pre-trained protein models, representing a significant advancement over pre-trained protein language models in various downstream tasks. However, most existing…

Machine Learning · Computer Science 2024-06-04 Jiale Zhao , Wanru Zhuang , Jia Song , Yaqi Li , Shuqi Lu

Accurately predicting molecular properties is a challenging but essential task in drug discovery. Recently, many mono-modal deep learning methods have been successfully applied to molecular property prediction. However, the inherent…

Machine Learning · Computer Science 2024-09-16 Xiaohua Lu , Liangxu Xie , Lei Xu , Rongzhi Mao , Shan Chang , Xiaojun Xu

Epoxy polymers are used in wide range of applications. The properties and performance of epoxy polymers depend upon various factors like the type of constituents and their proportions used and other process parameters. The conventional way…

Materials Science · Physics 2025-05-08 Sindu B. S. , Jan Hamaekers

We introduce PolyRecommender, a multimodal discovery framework that integrates chemical language representations from PolyBERT with molecular graph-based representations from a graph encoder. The system first retrieves candidate polymers…

Machine Learning · Computer Science 2025-11-04 Xin Wang , Yunhao Xiao , Rui Qiao

Speech-driven 3D facial animation has improved a lot recently while most related works only utilize acoustic modality and neglect the influence of visual and textual cues, leading to unsatisfactory results in terms of precision and…

Computer Vision and Pattern Recognition · Computer Science 2023-12-06 Tianshun Han , Shengnan Gui , Yiqing Huang , Baihui Li , Lijian Liu , Benjia Zhou , Ning Jiang , Quan Lu , Ruicong Zhi , Yanyan Liang , Du Zhang , Jun Wan

The limited extrapolative power of structure-based machine learning (ML) models is a critical bottleneck in chemical discovery, particularly for industrial R&D, where navigating uncharted chemical space to find next-generation materials or…

Molecular dynamics (MD) simulations enable the description of ma- terial properties and processes with atomistic detail by numerically solv- ing the time evolution of every atom in the system. We introduce Poly- merModeler, a…

Materials Science · Physics 2015-03-16 Benjamin P. Haley , Chunyu Li , Nathaniel Wilson , Eugenio Jaramillo , Alejandro Strachan

Polygonal modeling is a core task of content creation in Computer Graphics. The complexity of modeling, in terms of the number and the order of operations and time required to execute them makes it challenging to learn and execute. Our goal…

Computer Vision and Pattern Recognition · Computer Science 2022-03-30 I-Chao Shen , Yu Ju Chen , Oliver van Kaick , Takeo Igarashi

Molecular representation learning plays a crucial role in advancing applications such as drug discovery and material design. Existing work leverages 2D and 3D modalities of molecular information for pre-training, aiming to capture…

Machine Learning · Computer Science 2025-10-09 Tengwei Song , Min Wu , Yuan Fang
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