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The transport of intensity equation (TIE) has revolutionized phase retrieval in optical microscopy, yet its application to complex media with absorption/scattering remains challenging. Here, we present a coupled TIE-TPE (transport of phase…

Image tokenization plays a central role in modern generative modeling by mapping visual inputs into compact representations that serve as an intermediate signal between pixels and generative models. Diffusion-based decoders have recently…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Chuhan Wang , Hao Chen

Optical biosensors are indispensable in medical and environmental diagnostics, yet existing approaches are fundamentally limited in their sensitivity due to ensemble-averaged measurements. Digital biosensing has emerged as a promising…

Many self-supervised denoising approaches have been proposed in recent years. However, these methods tend to overly smooth images, resulting in the loss of fine structures that are essential for medical applications. In this paper, we…

Image and Video Processing · Electrical Eng. & Systems 2025-04-02 Basar Demir , Yikang Liu , Xiao Chen , Eric Z. Chen , Lin Zhao , Boris Mailhe , Terrence Chen , Shanhui Sun

Adaptive physics-informed super-resolution diffusion is developed for non-invasive virtual diagnostics of the 6D phase space density of charged particle beams. An adaptive variational autoencoder (VAE) embeds initial beam condition images…

Machine Learning · Computer Science 2025-01-14 Alexander Scheinker

As a label-free imaging technique, quantitative phase imaging (QPI) provides optical path length information of transparent specimens for various applications in biology, materials science, and engineering. Multispectral QPI measures…

Optics · Physics 2023-08-29 Che-Yung Shen , Jingxi Li , Deniz Mengu , Aydogan Ozcan

Multi-spectral quantitative phase imaging (MS-QPI) is a cutting-edge label-free technique to determine the morphological changes, refractive index variations and spectroscopic information of the specimens. The bottleneck to implement this…

In Fourier ptychography, multiple low resolution images are captured and subsequently combined computationally into a high-resolution, large-field of view micrograph. A theoretical image-formation model based on the assumption of plane-wave…

Optics · Physics 2022-06-22 Tomas Aidukas , Lars Loetgering , Andrew Robert Harvey

We present a data-driven approach to compensate for optical aberration in calibration-free quantitative phase imaging (QPI). Unlike existing methods that require additional measurements or a background region to correct aberrations, we…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Taean Chang , Youngju Jo , Gunho Choi , Donghun Ryu , Hyun-Seok Min , Yongkeun Park

In this letter, a high-fidelity single-shot differential quantitative phase microscopy (dQPM) method is presented to effectively image nearly transparent biological samples. The proposed method is based on a common-path Sagnac…

In order to efficiently image a non-absorbing sample (a phase object), dedicated phase contrast optics are required. Typically, these optics are designed with the assumption that the sample is weakly scattering, implying a linear relation…

Optics · Physics 2020-10-22 Stewart Koppell , Mark Kasevich

We propose and demonstrate a new phase retrieval method for imaging through random media. Although methods to recover the Fourier amplitude through random distortions are well established, recovery of the Fourier phase has been a more…

Optics · Physics 2021-05-14 Byungjae Hwang , Taeseong Woo , Cheolwoo Ahn , Jung-Hoon Park

Recent studies have demonstrated that the forward diffusion process is crucial for the effectiveness of diffusion models in terms of generative quality and sampling efficiency. We propose incorporating an analytical image attenuation…

Computer Vision and Pattern Recognition · Computer Science 2024-12-02 Yuhang Huang , Zheng Qin , Xinwang Liu , Kai Xu

Generative diffusion models have emerged as a powerful tool for high-quality image synthesis, yet their iterative nature demands significant computational resources. This paper proposes an efficient time step sampling method based on an…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Haeil Lee , Hansang Lee , Seoyeon Gye , Junmo Kim

Knee osteoarthritis (KOA) is a prevalent musculoskeletal disorder, often diagnosed using X-rays due to its cost-effectiveness. While Magnetic Resonance Imaging (MRI) provides superior soft tissue visualization and serves as a valuable…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Zhe Wang , Yung Hsin Chen , Aladine Chetouani , Fabian Bauer , Yuhua Ru , Fang Chen , Liping Zhang , Rachid Jennane , Mohamed Jarraya

Diffusion-based Image Editing (DIE) is an emerging research hot-spot, which often applies a semantic mask to control the target area for diffusion-based editing. However, most existing solutions obtain these masks via manual operations or…

Computer Vision and Pattern Recognition · Computer Science 2024-01-24 Siyu Zou , Jiji Tang , Yiyi Zhou , Jing He , Chaoyi Zhao , Rongsheng Zhang , Zhipeng Hu , Xiaoshuai Sun

Many naturally-occuring models in the sciences are well-approximated by simplified models, using multiscale techniques. In such settings it is natural to ask about the relationship between inverse problems defined by the original problem…

Numerical Analysis · Mathematics 2019-02-28 Kit Newton , Qin Li , Andrew Stuart

Medical image segmentation is crucial for clinical diagnosis and treatment planning. Traditional methods typically produce a single segmentation mask, failing to capture inherent uncertainty. Recent generative models enable the creation of…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Huynh Trinh Ngoc , Toan Nguyen Hai , Ba Luong Son , Long Tran Quoc

In radiation therapy (RT), the reliance on pre-treatment computed tomography (CT) images encounter challenges due to anatomical changes, necessitating adaptive planning. Daily cone-beam CT (CBCT) imaging, pivotal for therapy adjustment,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Joonil Hwang , Sangjoon Park , NaHyeon Park , Seungryong Cho , Jin Sung Kim

Accurate single cell detection in brightfield microscopy is crucial for biological research, yet data scarcity and annotation bottlenecks limit the progress of deep learning methods. We investigate the use of unconditional models to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Mario de Jesus da Graca , Jörg Dahlkemper , Peer Stelldinger