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Conical channels filled with an aqueous electrolyte have been proposed as promising candidates for iontronic neuromorphic circuits. This is facilitated by a novel analytical model for the internal channel dynamics [Kamsma et al.,…

Biological Physics · Physics 2024-01-31 T. M. Kamsma , W. Q. Boon , C. Spitoni , R. van Roij

Experiments have shown that the conductance of conical channels, filled with an aqueous electrolyte, can strongly depend on the history of the applied voltage. These channels hence have a memory and are promising elements in brain-inspired…

Soft Condensed Matter · Physics 2023-06-28 T. M. Kamsma , W. Q. Boon , T. ter Rele , C. Spitoni , R. van Roij

Conical microfluidic channels filled with electrolytes exhibit volatile memristive behavior, offering a promising platform for energy-efficient, neuromorphic computing. Here, we integrate these iontronic channels as additional nonlinear…

Soft Condensed Matter · Physics 2026-04-08 Nex C. X. Stuhlmüller , René van Roij , Marjolein Dijkstra

Inspired by the brain, we present a physical alternative to traditional digital neural networks -- a microfluidic network in which nodes are connected by conical, electrolyte-filled channels acting as memristive iontronic synapses. Their…

Soft Condensed Matter · Physics 2025-11-07 Monica Conte , René van Roij , Marjolein Dijkstra

The brain's remarkable and efficient information processing capability is driving research into brain-inspired (neuromorphic) computing paradigms. Artificial aqueous ion channels are emerging as an exciting platform for neuromorphic…

Soft Condensed Matter · Physics 2024-04-26 T. M. Kamsma , J. Kim , K. Kim , W. Q. Boon , C. Spitoni , J. Park , R. van Roij

Fluidic iontronics is emerging as a distinctive platform for implementing neuromorphic circuits, characterized by its reliance on the same aqueous medium and ionic signal carriers as the brain. Drawing upon recent theoretical advancements…

Soft Condensed Matter · Physics 2024-06-03 T. M. Kamsma , E. A. Rossing , C. Spitoni , R. van Roij

Specific molecular interactions underlie unexpected and useful phenomena in nanofluidic systems, but require descriptions that go beyond traditional macroscopic hydrodynamics. In this letter, we demonstrate how equilibrium molecular…

Mesoscale and Nanoscale Physics · Physics 2023-06-07 Phillip Helms , Anthony R. Poggioli , David T. Limmer

Chemotaxis is the response of a particle to a gradient in the chemical composition of the environment. While it was originally observed for biological organisms, it is of great interest in the context of synthetic active particles such as…

Soft Condensed Matter · Physics 2017-05-02 Laurens Deprez , Pierre de Buyl

A hitherto unexploited characteristic feature of emerging iontronic devices for information processing is the intrinsic mobility of the medium (water) of dissolved ions in aqueous electrolytes, which therefore not only respond to voltage…

Soft Condensed Matter · Physics 2024-04-24 A. Barnaveli , T. M. Kamsma , W. Q. Boon , R. van Roij

The performances of lubricated systems widely used in natural, biological, and artificial settings are traditionally dictated by their load bearing capacities. Here we unveil that, by exploiting a unique coupling between interfacial…

Fluid Dynamics · Physics 2022-07-26 Siddhartha Mukherjee , Jayabrata Dhar , Sunando DasGupta , Suman Chakraborty

Nanofluidic memristors have demonstrated great potential for neuromorphic system applications with the advantages of low energy consumption and excellent biocompatibility. Here, an effective way is developed to regulate the memristive…

Chemical Physics · Physics 2025-10-21 Zhe Liu , Hongwen Zhang , Di Liu , Tianyi Sui , Yinghua Qiu

Developing an organoid computing platform from neurons in vitro demands stable, precisely controlled microenvironments. To address this requirement, we designed, simulated, and fabricated a microfluidic device featuring hexagonal wells…

Fluid Dynamics · Physics 2025-08-04 Maxx Yung

Fine-tuned ion transport across nanoscale pores is key to many biological processes such as neurotransmission. Recent advances have enabled the confinement of water and ions to two dimensions, unveiling transport properties unreachable at…

Soft Condensed Matter · Physics 2023-01-18 P. Robin , T. Emmerich , A. Ismail , A. Niguès , Y. You , G. -H. Nam , A. Keerthi , A. Siria , A. K. Geim , B. Radha , L. Bocquet

In this article we address the three-dimensional modeling and simulation of biological ion channels using a continuum-based approach. Our multi-physics formulation self-consistently combines, to the best of our knowledge for the first time,…

Numerical Analysis · Mathematics 2015-09-25 Riccardo Sacco , Paolo Airoldi , Aurelio G. Mauri , Joseph W. Jerome

The transport of fluids at the nanoscale is fundamental to manifold biological and industrial processes, ranging from neurotransmission to ultrafiltration. Yet, it is only recently that well-controlled channels with cross-sections as small…

Mesoscale and Nanoscale Physics · Physics 2022-10-05 Nikita Kavokine , Paul Robin , Lydéric Bocquet

Reliable and controllable switches are crucial in nanofluidics and iontronics. Ion channels in nature serve as a rich source of inspiration due to their intricate mechanisms modulated by stimuli like pressure, temperature, chemicals, and…

Mesoscale and Nanoscale Physics · Physics 2023-10-17 Gonçalo Paulo , Alberto Gubbiotti , Giovanni Di Muccio , Alberto Giacomello

Molecular circuits capable of autonomous learning could unlock novel applications in fields such as bioengineering and synthetic biology. To this end, existing chemical implementations of neural computing have mainly relied on emulating…

Machine Learning · Computer Science 2025-09-23 Rajiv Teja Nagipogu , John H. Reif

We present an integrated iontronic memristor circuit that reproduces biologically inspired Spike Rate-Dependent Plasticity (SRDP) and functions as a physical nonlinear frequency kernel, which we demonstrate can be used to classify natural…

Soft Condensed Matter · Physics 2026-03-23 T. M. Kamsma , Y. Gu , D. Shi , C. Spitoni , M. Dijkstra , R. van Roij , Y. Xie

Microfluidic channels have emerged as useful tools to control dynamic forcing on transported microscale objects, as encountered in emulsions, biological flows, and other soft matter systems. Tailored channel designs enable precise…

Soft Condensed Matter · Physics 2026-05-29 Matteo Milani , Joshua D. McGraw , Anke Lindner Stefano Aime

Bio-inspired neural networks have the potential to advance our understanding of neural computation and improve the state-of-the-art of AI systems. Bio-electrical synapses directly transmit neural signals, by enabling fast current flow…

Neural and Evolutionary Computing · Computer Science 2024-01-18 Mónika Farsang , Mathias Lechner , David Lung , Ramin Hasani , Daniela Rus , Radu Grosu
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