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Epilepsy is one of the most prevalent brain disorders that disrupts the lives of millions worldwide. For patients with drug-resistant seizures, there exist implantable devices capable of monitoring neural activity, promptly triggering…
Objective Kalman filtering has previously been applied to track neural model states and parameters, particularly at the scale relevant to EEG. However, this approach lacks a reliable method to determine the initial filter conditions and…
Von Economo neurons (VENs) are selectively lost in behavioural-variant frontotemporal dementia (bvFTD) and reduced in autism spectrum conditions (ASC), yet their computational role in social learning remains unexplained. We train a spiking…
We present a nonlinear data-driven Model Predictive Control (MPC) algorithm for deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD). Although DBS is typically implemented in open-loop, closed-loop DBS (CLDBS) uses the…
The primary motor cortex appears to be in the center of transcranial magnetic stimulation (TMS). It is one of few locations that provide directly observable responses, and its physiology serves as model or reference for almost all other TMS…
Neurons and networks in the cerebral cortex must operate reliably despite multiple sources of noise. To evaluate the impact of both input and output noise, we determine the robustness of single-neuron stimulus selective responses, as well…
Noninvasive brain stimulation (NIBS) encompasses transcranial stimulation techniques that can influence brain excitability. These techniques have the potential to treat conditions like depression, anxiety, and chronic pain, and to provide…
While computer vision models have made incredible strides in static image recognition, they still do not match human performance in tasks that require the understanding of complex, dynamic motion. This is notably true for real-world…
During the past two decades, epileptic seizure detection and prediction algorithms have evolved rapidly. However, despite significant performance improvements, their hardware implementation using conventional technologies, such as…
Chronic pain affects about 100 million adults in the US. Despite their great need, neuropharmacology and neurostimulation therapies for chronic pain have been associated with suboptimal efficacy and limited long-term success, as their…
Epilepsy is a neurological condition such that it affects the brain and the nervous system. It is characterized by recurrent seizures, which are physical reactions to sudden, usually brief, excessive electrical discharges in a group of…
Background: Enlargement of perivascular spaces (PVS) is common in neurodegenerative disorders including cerebral small vessel disease, Alzheimer's disease, and Parkinson's disease. PVS enlargement may indicate impaired clearance pathways…
Electroencephalogram (EEG) is a prominent way to measure the brain activity for studying epilepsy, thereby helping in predicting seizures. Seizure prediction is an active research area with many deep learning based approaches dominating the…
In this study, we present a criterion based on the analysis of EEG signals through the mean of the conventional power spectral density (PSD) in the aim to localize and detect the epileptic area of the brain. Firstly, as the EEG signals are…
Continuous monitoring of non-invasive skin sympathetic nerve activity (SKNA) holds promise for understanding the sympathetic nervous system (SNS) dynamics in various physiological and pathological conditions. However, muscle noise artifacts…
This project develops and trains a Recurrent Neural Network (RNN) that monitors sleeping infants from an auxiliary microphone for cases of Sudden Infant Death Syndrome (SIDS), manifested in sudden or gradual respiratory arrest. To minimize…
The Synthetic Nervous System (SNS) is a biologically inspired neural network (NN). Due to its capability of capturing complex mechanisms underlying neural computation, an SNS model is a candidate for building compact and interpretable NN…
Neural networks are emerging as a tool for scalable data-driven simulation of high-dimensional dynamical systems, especially in settings where numerical methods are infeasible or computationally expensive. Notably, it has been shown that…
Over the past decade, high-frequency oscillations (HFOs) have been studied as a promising biomarker for localizing epileptogenic areas in drug-resistant patients requiring pre-surgical intervention, while exploiting intracranial…
Accurate assessment of neuromuscular reflexes, such as the H-reflex, plays a critical role in sports science, rehabilitation, and clinical neurology. Traditional analysis of H-reflex EMG waveforms is subject to variability and…