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We present a method that compares the protein interaction networks of two species to detect functionally similar (conserved) protein modules between them. The method is based on an algorithm we developed to identify matching subgraphs…

Molecular Networks · Quantitative Biology 2007-05-23 Manikandan Narayanan , Richard M. Karp

Modern sociology has profoundly uncovered many convincing social criteria for behavioural analysis. Unfortunately, many of them are too subjective to be measured and presented in online social networks. On the other hand, data mining…

Social and Information Networks · Computer Science 2023-01-09 Xiangguo Sun , Hong Cheng , Bo Liu , Jia Li , Hongyang Chen , Guandong Xu , Hongzhi Yin

Many real networks in social sciences, biological and biomedical sciences or computer science have an inherent structure of simplicial complexes reflecting many-body interactions. Therefore, to analyse topological and dynamical properties…

Algebraic Topology · Mathematics 2020-04-16 Daniel Hernández Serrano , Darío Sánchez Gómez

Proteins perform much of the work in living organisms, and consequently the development of efficient computational methods for protein representation is essential for advancing large-scale biological research. Most current approaches…

Quantitative Methods · Quantitative Biology 2023-06-09 Francesco Ceccarelli , Lorenzo Giusti , Sean B. Holden , Pietro Liò

Graph databases have been the subject of significant research and development. Problems such as modularity, centrality, alignment, and clustering have been formalized and solved in various application contexts. In this paper, we focus on…

Social and Information Networks · Computer Science 2019-08-09 Vikram Ravindra , Huda Nassar , David F. Gleich , Ananth Grama

Given a network, the critical node detection problem finds a subset of nodes whose removal disrupts the network connectivity. Since many real-world systems are naturally modeled as graphs, assessing the vulnerability of the network is…

Discrete Mathematics · Computer Science 2025-12-02 Tuguldur Bayarsaikhan , Altannar Chinchuluun , Ashwin Arulselvan , Panos Pardalos

A new heuristic based on vertex invariants is developed to rapidly distinguish non-isomorphic graphs to a desired level of accuracy. The method is applied to sample subgraphs from an E.coli protein interaction network, and as a probe for…

Quantitative Methods · Quantitative Biology 2009-11-13 Kim Baskerville , Maya Paczuski

We consider representation learning for proteins with 3D structures. We build 3D graphs based on protein structures and develop graph networks to learn their representations. Depending on the levels of details that we wish to capture,…

Machine Learning · Computer Science 2023-03-07 Limei Wang , Haoran Liu , Yi Liu , Jerry Kurtin , Shuiwang Ji

The $\boldsymbol{\beta}$-model for random graphs is commonly used for representing pairwise interactions in a network with degree heterogeneity. Going beyond pairwise interactions, Stasi et al. (2014) introduced the hypergraph…

Statistics Theory · Mathematics 2024-06-07 Sagnik Nandy , Bhaswar B. Bhattacharya

The topological structure of complex networks has fascinated researchers for several decades, resulting in the discovery of many universal properties and reoccurring characteristics of different kinds of networks. However, much less is…

Social and Information Networks · Computer Science 2017-06-28 Yvonne Anne Pignolet , Matthieu Roy , Stefan Schmid , Gilles Tredan

The topological structure of complex networks has fascinated researchers for several decades, resulting in the discovery of many universal properties and reoccurring characteristics of different kinds of networks. However, much less is…

Social and Information Networks · Computer Science 2017-03-02 Yvonne Anne Pignolet , Matthieu Roy , Stefan Schmid , Gilles Tredan

Complex networks often exhibit community structure, with communities corresponding to denser subgraphs in which nodes are closely linked. When modelling systems where interactions extend beyond node pairs to arbitrary numbers of nodes,…

Physics and Society · Physics 2025-10-16 Bianka Kovács , Barnabás Benedek , Gergely Palla

Much of the past work in network analysis has focused on analyzing discrete graphs, where binary edges represent the "presence" or "absence" of a relationship. Since traditional network measures (e.g., betweenness centrality) utilize a…

Social and Information Networks · Computer Science 2011-04-05 Joseph J. Pfeiffer , Jennifer Neville

Graph, as an important data representation, is ubiquitous in many real world applications ranging from social network analysis to biology. How to correctly and effectively learn and extract information from graph is essential for a large…

Machine Learning · Computer Science 2020-10-27 Xiaodong Jiang , Ronghang Zhu , Pengsheng Ji , Sheng Li

Protein-protein interactions (PPIs) play key roles in a broad range of biological processes. Numerous strategies have been proposed for predicting PPIs, and among them, graph-based methods have demonstrated promising outcomes owing to the…

Machine Learning · Computer Science 2024-04-19 Mingda Xu , Peisheng Qian , Ziyuan Zhao , Zeng Zeng , Jianguo Chen , Weide Liu , Xulei Yang

The structure of many complex networks includes edge directionality and weights on top of their topology. Network analysis that can seamlessly consider combination of these properties are desirable. In this paper, we study two important…

Social and Information Networks · Computer Science 2021-11-24 Frederique Oggier , Silivanxay Phetsouvanh , Anwitaman Datta

As the calculation of centrality in complex networks becomes increasingly vital across technological, biological, and social systems, precise and scalable ranking methods are essential for understanding these networks. This paper introduces…

Social and Information Networks · Computer Science 2025-01-30 Hao Ren , Jiaojiao Jiang

Knowledge graphs have been shown to play a significant role in current knowledge mining fields, including life sciences, bioinformatics, computational social sciences, and social network analysis. The problem of link prediction bears many…

Social and Information Networks · Computer Science 2024-09-19 Jens Dörpinghaus , Tobias Hübenthal , Denis Stepanov

We introduce a taxonomy of interaction types and show that graphs are focal hypergraphs: every graph is canonically a focal hypergraph via its closed neighbourhood structure, and every graph dynamical model is a special case of the general…

Physics and Society · Physics 2026-03-05 Elkaïoum M. Moutuou

Networks have become a key approach to understanding systems of interacting objects, unifying the study of diverse phenomena including biological organisms and human society. One crucial step when studying the structure and dynamics of…

Physics and Society · Physics 2010-09-16 Yong-Yeol Ahn , James P. Bagrow , Sune Lehmann