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In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality…

Molecular Networks · Quantitative Biology 2007-05-23 Oliver Mason , Mark Verwoerd

Centrality is one of the most fundamental metrics in network science. Despite an abundance of methods for measuring centrality of individual vertices, there are by now only a few metrics to measure centrality of individual edges. We modify…

Physics and Society · Physics 2019-09-25 Timo Bröhl , Klaus Lehnertz

In this paper, we compared cancerous and normal cell according to their protein-protein interaction network. Cancer is one of the complicated diseases and experimental investigations have been showed that protein interactions have an…

Molecular Networks · Quantitative Biology 2019-03-19 Hossein A. Rahmani , AliReza Khanteymoori , Mohammad Olyaee

Going beyond networks, to include higher-order interactions of arbitrary sizes, is a major step to better describe complex systems. In the resulting hypergraph representation, tools to identify structures and central nodes are scarce. We…

Physics and Society · Physics 2023-10-11 Marco Mancastroppa , Iacopo Iacopini , Giovanni Petri , Alain Barrat

Complex networks or graphs provide a powerful framework to understand importance of individuals and their interactions in real-world complex systems. Several graph theoretical measures have been introduced to access importance of the…

Physics and Society · Physics 2020-04-08 Priodyuti Pradhan , Angeliya C. U. , Sarika Jalan

Hypergraphs serve as an effective tool widely adopted to characterize higher-order interactions in complex systems. The most intuitive and commonly used mathematical instrument for representing a hypergraph is the incidence matrix, in which…

Social and Information Networks · Computer Science 2026-04-22 Junhao Bian , Yilin Bi , Tao Zhou

This paper presents a novel graph-based deep learning model for tasks involving relations between two nodes (edge-centric tasks), where the focus lies on predicting relationships and interactions between pairs of nodes rather than node…

Machine Learning · Computer Science 2025-07-08 Eugenio Borzone , Leandro Di Persia , Matias Gerard

The network paradigm is increasingly used to describe the topology and dynamics of complex systems. Here we review the results of the topological analysis of protein structures as molecular networks describing their small-world character,…

Biomolecules · Quantitative Biology 2007-06-10 Csaba Bode , Istvan A. Kovacs , Mate S. Szalay , Robin Palotai , Tamas Korcsmaros , Peter Csermely

In graph-based applications, a common task is to pinpoint the most important or ``central'' vertex in a (directed or undirected) graph, or rank the vertices of a graph according to their importance. To this end, a plethora of so-called…

Artificial Intelligence · Computer Science 2023-02-28 Andreas Pieris , Jorge Salas

Network metrics form a fundamental part of the network analysis toolbox. Used to quantitatively measure different aspects of the network, these metrics can give insights into the underlying network structure and function. In this work, we…

Machine Learning · Statistics 2015-06-04 Harold Soh

Graph neural network, as a powerful graph representation technique based on deep learning, has shown superior performance and attracted considerable research interest. However, it has not been fully considered in graph neural network for…

Social and Information Networks · Computer Science 2021-01-21 Xiao Wang , Houye Ji , Chuan Shi , Bai Wang , Peng Cui , P. Yu , Yanfang Ye

Identifying influential nodes and edges in directed networks remains a fundamental challenge across domains from social influence to biological regulation. Most existing centrality measures face a critical limitation: they either discard…

Social and Information Networks · Computer Science 2026-02-18 Jorge Luiz Franco , Thomas Peron , Alcebiades Dal Col , Fabiano Petronetto , Filipe Alves Neto Verri , Eric K. Tokuda , Luiz Gustavo Nonato

Network theory has proven invaluable in unraveling complex protein interactions. Previous studies have employed statistical methods rooted in network theory, including the Gaussian graphical model, to infer networks among proteins,…

Methodology · Statistics 2026-05-07 Seungjun Ahn , Eun Jeong Oh

Hypergraphs, encoding structured interactions among any number of system units, have recently proven a successful tool to describe many real-world biological and social networks. Here we propose a framework based on statistical inference to…

Social and Information Networks · Computer Science 2022-12-01 Martina Contisciani , Federico Battiston , Caterina De Bacco

Being cognizant of the abundance of multi-body interactions in various complex systems, here we investigate a possible way to incorporate multi-body interactions in dynamical networks. Adopting hypergraph as the underlying architecture aids…

Dynamical Systems · Mathematics 2023-03-24 Anirban Banerjee , Samiron Parui

In this paper, we present a framework for studying the following fundamental question in network analysis: How should one assess the centralities of nodes in an information/influence propagation process over a social network? Our framework…

Social and Information Networks · Computer Science 2018-10-24 Wei Chen , Shang-Hua Teng , Hanrui Zhang

Psychological network approaches propose to see symptoms or questionnaire items as interconnected nodes, with links between them reflecting pairwise statistical dependencies evaluated cross-sectional, time-series, or panel data. These…

Most statistical models for networks focus on pairwise interactions between nodes. However, many real-world networks involve higher-order interactions among multiple nodes, such as co-authors collaborating on a paper. Hypergraphs provide a…

Methodology · Statistics 2025-09-16 Yichao Chen , Jingfei Zhang , Ji Zhu

A network can be analyzed at different topological scales, ranging from single nodes to motifs, communities, up to the complete structure. We propose a novel intermediate-level topological analysis that considers non-overlapping subgraphs…

Computational Physics · Physics 2009-11-13 Lucas Antiqueira , Luciano da Fontoura Costa

In this paper, we consider the statistical analysis of a protein interaction network. We propose a Bayesian model that uses a hierarchy of probabilistic assumptions about the way proteins interact with one another in order to: (i) identify…

Molecular Networks · Quantitative Biology 2007-11-15 Edoardo M Airoldi , David M Blei , Stephen E Fienberg , Eric P Xing