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Molecular Property Prediction (MPP) plays a pivotal role across diverse domains, spanning drug discovery, material science, and environmental chemistry. Fueled by the exponential growth of chemical data and the evolution of artificial…

Machine Learning · Computer Science 2024-08-23 Tanya Liyaqat , Tanvir Ahmad , Chandni Saxena

Model predictive control (MPC) has become a hot cake technology for various applications due to its ability to handle multi-input multi-output systems with physical constraints. The optimization solvers require considerable time, limiting…

Systems and Control · Electrical Eng. & Systems 2022-01-11 Abhijith Sharma , Chaitanya Jugade , Shreya Yawalkar , Vaishali Patne , Deepak Ingole , Dayaram Sonawane

Large Language Model (LLM)-based agentic systems rely on in-context policy documents encoding diverse business rules. As requirements grow, these documents expand rapidly, causing high computational overhead. This motivates developing…

Artificial Intelligence · Computer Science 2025-10-14 Jiateng Liu , Zhenhailong Wang , Xiaojiang Huang , Yingjie Li , Xing Fan , Xiang Li , Chenlei Guo , Ruhi Sarikaya , Heng Ji

The combination of high-throughput experimentation techniques and machine learning (ML) has recently ushered in a new era of accelerated material discovery, enabling the identification of materials with cutting-edge properties. However, the…

In the rapidly evolving field of business process management, there is a growing need for analytical tools that can transform complex data into actionable insights. This research introduces a novel approach by integrating Large Language…

Computation and Language · Computer Science 2024-05-20 Mehrdad Agha Mohammad Ali Kermani , Hamid Reza Seddighi , Mehrdad Maghsoudi

Identification of antimicrobial peptides is an important and necessary issue in today's era. Antimicrobial peptides are essential as an alternative to antibiotics for biomedical applications and many other practical applications. These…

Machine Learning · Computer Science 2025-12-17 Reyhaneh Keshavarzpour , Eghbal Mansoori

Determinantal Point Processes (DPPs) provide an elegant and versatile way to sample sets of items that balance the point-wise quality with the set-wise diversity of selected items. For this reason, they have gained prominence in many…

Machine Learning · Statistics 2019-01-09 Zelda Mariet , Yaniv Ovadia , Jasper Snoek

Peptide-drug conjugates (PDCs) represent a promising therapeutic avenue for human diseases, particularly in cancer treatment. Systematic elucidation of structure-activity relationships (SARs) and accurate prediction of the activity of PDCs…

Machine Learning · Computer Science 2025-06-17 Yun Liu , Jintu Huang , Yingying Zhu , Congrui Wen , Yu Pang , Ji-Quan Zhang , Ling Wang

Unstructured neural network pruning algorithms have achieved impressive compression rates. However, the resulting - typically irregular - sparse matrices hamper efficient hardware implementations, leading to additional memory usage and…

The high computational and memory requirements of large language model (LLM) inference make it feasible only with multiple high-end accelerators. Motivated by the emerging demand for latency-insensitive tasks with batched processing, this…

We discuss the use of the determinantal point process (DPP) as a prior for latent structure in biomedical applications, where inference often centers on the interpretation of latent features as biologically or clinically meaningful…

Methodology · Statistics 2017-02-28 Yanxun Xu , Peter Mueller , Donatello Telesca

Intelligence is key to advancing integrated circuit (IC) fabrication. Recent breakthroughs in Large Multimodal Models (LMMs) have unlocked extraditionary abilities in understanding images and text, fostering intelligent fabrication.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Yuqi Jiang , Xudong Lu , Qian Jin , Qi Sun , Hanming Wu , Cheng Zhuo

Understanding how small molecules perturb gene expression is essential for uncovering drug mechanisms, predicting off-target effects, and identifying repurposing opportunities. While prior deep learning frameworks have integrated multimodal…

Machine Learning · Computer Science 2026-01-01 Pascal Passigan , Kevin Zhu , Angelina Ning

Large embedding tables are indispensable in modern recommendation systems, thanks to their ability to effectively capture and memorize intricate details of interactions among diverse entities. As we explore integrating large embedding…

The design of novel protein sequences with targeted functionalities underpins a central theme in protein engineering, impacting diverse fields such as drug discovery and enzymatic engineering. However, navigating this vast combinatorial…

Biomolecules · Quantitative Biology 2024-02-19 Yiheng Zhu , Zitai Kong , Jialu Wu , Weize Liu , Yuqiang Han , Mingze Yin , Hongxia Xu , Chang-Yu Hsieh , Tingjun Hou

Motivation: Peptide-protein interactions (PepPIs) are central to cellular regulation and peptide therapeutics, but experimental characterization remains too slow for large-scale screening. Existing methods usually emphasize either…

Machine Learning · Computer Science 2026-04-28 Chupei Tang , Junxiao Kong , Moyu Tang , Di Wang , Jixiu Zhai , Ronghao Xie , Shangkun Sima , Tianchi Lu

Determinantal point processes (DPPs) have attracted significant attention in machine learning for their ability to model subsets drawn from a large item collection. Recent work shows that nonsymmetric DPP (NDPP) kernels have significant…

Machine Learning · Computer Science 2021-04-14 Mike Gartrell , Insu Han , Elvis Dohmatob , Jennifer Gillenwater , Victor-Emmanuel Brunel

The complexity, interdependence, and rapid evolution of 3GPP specifications present fundamental challenges for ensuring the security of modern cellular networks. Manual reviews and existing automated approaches, which often depend on…

Cryptography and Security · Computer Science 2026-04-02 Ke Xie , Xingyi Zhao , Min-Yue Chen , Yu-An Chen , Yiwen Hu , Munshi Saifuzzaman , Wen Li , Shuhan Yuan , Guan-Hua Tu , Tian Xie

Therapeutic peptides show promise in targeting previously undruggable binding sites, with recent advancements in deep generative models enabling full-atom peptide co-design for specific protein receptors. However, the critical role of…

Machine Learning · Computer Science 2026-01-09 Fang Wu , Zhengyuan Zhou , Shuting Jin , Xiangxiang Zeng , Jure Leskovec , Jinbo Xu

Attempts to render deep learning models interpretable, data-efficient, and robust have seen some success through hybridisation with rule-based systems, for example, in Neural Theorem Provers (NTPs). These neuro-symbolic models can induce…

Artificial Intelligence · Computer Science 2020-08-25 Pasquale Minervini , Sebastian Riedel , Pontus Stenetorp , Edward Grefenstette , Tim Rocktäschel
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