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Understanding the dynamic reorganization of brain networks is critical for predicting cognitive decline, neurological progression, and individual variability in clinical outcomes. This work proposes a multimodal graph neural network…

Machine Learning · Computer Science 2026-02-11 Preksha Girish , Rachana Mysore , Kiran K. N. , Hiranmayee R. , Shipra Prashanth , Shrey Kumar

We present a novel method for quantifying the microscopic structure of brain tissue. It is based on the automated recognition of interpretable features obtained by analyzing the shapes of cells. This contrasts with prevailing methods of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-10 Kui Qian , Litao Qiao , Beth Friedman , Edward O'Donnell , David Kleinfeld , Yoav Freund

Schizophrenia is a chronic neuropsychiatric disorder that causes distinct structural alterations within the brain. We hypothesize that deep learning applied to a structural neuroimaging dataset could detect disease-related alteration and…

Image and Video Processing · Electrical Eng. & Systems 2022-07-08 Junhao Zhang , Vishwanatha M. Rao , Ye Tian , Yanting Yang , Nicolas Acosta , Zihan Wan , Pin-Yu Lee , Chloe Zhang , Lawrence S. Kegeles , Scott A. Small , Jia Guo

Population analyses of functional connectivity have provided a rich understanding of how brain function differs across time, individual, and cognitive task. An important but challenging task in such population analyses is the identification…

Social and Information Networks · Computer Science 2020-08-19 James D. Wilson , Melanie Baybay , Rishi Sankar , Paul Stillman , Abbie M. Popa

Objective. Modelling is an important way to study the working mechanism of brain. While the characterization and understanding of brain are still inadequate. This study tried to build a model of brain from the perspective of thermodynamics…

Neurons and Cognition · Quantitative Biology 2021-03-30 Chenxi Zhou , Bin Yang , Wenliang Fan , Wei Li

Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process involving inflammation, tissue damage, and tissue repair, all…

The human brain is organized as a complex network, where connections between regions are characterized by both functional connectivity (FC) and structural connectivity (SC). While previous studies have primarily focused on network-level…

Foundation models are transforming neuroscience but are often prohibitively large, data-hungry, and difficult to deploy. Here, we introduce BrainSymphony, a lightweight and parameter-efficient foundation model with plug-and-play integration…

Quantitative Methods · Quantitative Biology 2026-02-13 Moein Khajehnejad , Forough Habibollahi , Devon Stoliker , Adeel Razi

Longitudinal brain analysis is essential for understanding healthy aging and identifying pathological deviations. Longitudinal registration of sequential brain MRI underpins such analyses. However, existing methods are limited by reliance…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Bailiang Jian , Jiazhen Pan , Yitong Li , Fabian Bongratz , Ruochen Li , Daniel Rueckert , Benedikt Wiestler , Christian Wachinger

Activity and motion analysis has the potential to be used as a diagnostic tool for mental disorders. However, to-date, little work has been performed in turning stratification measures of activity into useful symptom markers. The research…

Medical Physics · Physics 2019-08-19 Maxim Osipov

Brain age prediction serves as a powerful framework for assessing brain status and detecting deviations associated with neurodevelopmental and neurodegenerative disorders. However, most existing approaches emphasize whole-brain age…

Neurons and Cognition · Quantitative Biology 2026-02-10 Rongzhao He , Dalin Zhu , Ying Wang , Songhong Yue , Leilei Zhao , Yu Fu , Dan Wu , Bin Hu , Weihao Zheng

In this research, a number of popular network measurement algorithms have been applied to several brain networks (based on applicability of algorithms) for finding out statistical correlation among these popular network measurements which…

Neurons and Cognition · Quantitative Biology 2023-03-30 Rakib Hassan Pran

Brain-mapping techniques have proven to be vital in understanding the molecular, cellular, and functional mechanisms of the brain. Normal anatomical imaging can provide structural information on certain abnormalities in the brain. However…

Emerging Technologies · Computer Science 2013-01-03 Nivedita Daimiwal , M. Sundhararajan , Revati Shriram

Background/Introduction: In this paper, the neural network class of Self-Organising Maps (SOMs) is investigated in terms of its theoretical and applied validity for cognitive modelling, particularly of neurodevelopmental disorders. Methods:…

Neurons and Cognition · Quantitative Biology 2025-07-18 Spyridon Revithis , Nadine Marcus

Psychiatric neuroscience is increasingly aware of the need to define psychopathology in terms of abnormal neural computation. The central tool in this endeavour is the fitting of computational models to behavioural data. The most prominent…

Quantitative Methods · Quantitative Biology 2018-03-28 Abraham Nunes , Alexander Rudiuk

Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little…

Neurons and Cognition · Quantitative Biology 2015-06-16 Florian Klimm , Danielle S. Bassett , Jean M. Carlson , Peter J. Mucha

Functional and structural connectivity (FC/SC) are key multimodal biomarkers for brain analysis, yet their clinical utility is hindered by costly acquisition, complex preprocessing, and frequent missing modalities. Existing foundation…

Neurons and Cognition · Quantitative Biology 2025-11-11 Xiongri Shen , Jiaqi Wang , Yi Zhong , Zhenxi Song , Leilei Zhao , Liling Li , Yichen Wei , Lingyan Liang , Shuqiang Wang , Baiying Lei , Demao Deng , Zhiguo Zhang

Characterizing the brain dynamics during different cortical states can reveal valuable information about its patterns across various cognitive processes. In particular, studying the differences between awake and sleep stages can shed light…

Advancing the size and complexity of neural network models leads to an ever increasing demand for computational resources for their simulation. Neuromorphic devices offer a number of advantages over conventional computing architectures,…

Reliable segmentation of anatomical tissues of human head is a major step in several clinical applications such as brain mapping, surgery planning and associated computational simulation studies. Segmentation is based on identifying…

Computer Vision and Pattern Recognition · Computer Science 2023-09-14 Essam A. Rashed , Mohammad al-Shatouri , Ilkka Laakso , Akimasa Hirata