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Recent advancements in medicine have confirmed that brain disorders often comprise multiple subtypes of mechanisms, developmental trajectories, or severity levels. Such heterogeneity is often associated with demographic aspects (e.g., sex)…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Magdalini Paschali , Yu Hang Jiang , Spencer Siegel , Camila Gonzalez , Kilian M. Pohl , Akshay Chaudhari , Qingyu Zhao

Clinical deployment of automated brain MRI analysis faces a fundamental challenge: clinical data is heterogeneous and noisy, and high-quality labels are prohibitively costly to obtain. Self-supervised learning (SSL) can address this by…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Asbjørn Munk , Stefano Cerri , Vardan Nersesjan , Christian Hedeager Krag , Jakob Ambsdorf , Pablo Rocamora García , Julia Machnio , Peirong Liu , Suhyun Ahn , Nasrin Akbari , Yasmina Al Khalil , Kimberly Amador , Sina Amirrajab , Tal Arbel , Meritxell Bach Cuadra , Ujjwal Baid , Bhakti Baheti , Jaume Banus , Kamil Barbierik , Christoph Brune , Yansong Bu , Baptiste Callard , Yuhan Chen , Cornelius Crijnen , Corentin Dancette , Peter Drotar , Prasad Dutande , Nils D. Forkert , Saurabh Garg , Jakub Gazda , Matej Gazda , Benoît Gérin , Partha Ghosh , Weikang Gong , Pedro M. Gordaliza , Sam Hashemi , Tobias Heimann , Fucang Jia , Jiexin Jiang , Emily Kaczmarek , Chris Kang , Seung Kwan Kang , Mohammad Khazaei , Julien Khlaut , Petros Koutsouvelis , Jae Sung Lee , Yuchong Li , Mengye Lyu , Mingchen Ma , Anant Madabhushi , Klaus H. Maier-Hein , Pierre Manceron , Andrés Martínez Mora , Moona Mazher , Felix Meister , Nataliia Molchanova , Steven A. Niederer , Leonard Nürnberg , Jinah Park , Abdul Qayyum , Jonas Richiardi , Antoine Saporta , Branislav Setlak , Ning Shen , Justin Szeto , Constantin Ulrich , Puru Vaish , Vibujithan Vigneshwaran , Leroy Volmer , Zihao Wang , Siqi Wei , Anthony Winder , Jelmer M. Wolterink , Maxence Wynen , Chang Yang , Si Young Yie , Mostafa Mehdipour Ghazi , Akshay Pai , Espen Jimenez Solem , Sebastian Nørgaard Llambias , Mikael Boesen , Michael Eriksen Benros , Juan Eugenio Iglesias , Mads Nielsen

Our knowledge of the organisation of the human brain at the population-level is yet to translate into power to predict functional differences at the individual-level, limiting clinical applications, and casting doubt on the generalisability…

Neurons and Cognition · Quantitative Biology 2024-04-04 James K Ruffle , Robert J Gray , Samia Mohinta , Guilherme Pombo , Chaitanya Kaul , Harpreet Hyare , Geraint Rees , Parashkev Nachev

There is increasing evidence on the importance of brain morphology in predicting and classifying mental disorders. However, the vast majority of current shape approaches rely heavily on vertex-wise analysis that may not successfully capture…

Computer Vision and Pattern Recognition · Computer Science 2021-05-26 Yuexuan Wu , Suprateek Kundu , Jennifer S. Stevens , Negar Fani , Anuj Srivastava

Brain Functional Networks (BFNs), graph theoretical models of brain activity data, provide a systems perspective of complex functional connectivity within the brain. Neurological disorders are known to have basis in abnormal functional…

Quantitative Methods · Quantitative Biology 2016-08-30 Megha Singh , Rahul Badhwar , Ganesh Bagler

The determination of biological brain age is a crucial biomarker in the assessment of neurological disorders and understanding of the morphological changes that occur during aging. Various machine learning models have been proposed for…

Image and Video Processing · Electrical Eng. & Systems 2023-06-12 Mansoor Ahmed , Usama Sardar , Sarwan Ali , Shafiq Alam , Murray Patterson , Imdad Ullah Khan

Neural electrical activity is fundamental to brain function, underlying a range of cognitive and behavioral processes, including movement, perception, decision-making, and consciousness. Abnormal patterns of neural signaling often indicate…

Neurons and Cognition · Quantitative Biology 2025-09-03 Zhizhang Yuan , Fanqi Shen , Meng Li , Yuguo Yu , Chenhao Tan , Yang Yang

Deep Learning (DL) in neuroimaging has become increasingly relevant for detecting neurological conditions and neurodegenerative disorders. One of the most predominant biomarkers in neuroimaging is represented by brain age, which has been…

Image and Video Processing · Electrical Eng. & Systems 2025-11-20 Carlo Alberto Barbano , Matteo Brunello , Benoit Dufumier , Marco Grangetto

Age is an important variable to describe the expected brain's anatomy status across the normal aging trajectory. The deviation from that normative aging trajectory may provide some insights into neurological diseases. In neuroimaging,…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Human brain connectome studies aim at extracting and analyzing relevant features associated to pathologies of interest. Usually this consists in modeling the brain connectome as a graph and in using graph metrics as features. A fine brain…

Neurons and Cognition · Quantitative Biology 2020-05-04 Félix Renard , Christian Heinrich , Marine Bouthillon , Maleka Schenck , Francis Schneider , Stéphane Kremer , Sophie Achard

Brain structural MRI has been widely used to assess the future progression of cognitive impairment (CI). Previous learning-based studies usually suffer from the issue of small-sized labeled training data, while there exist a huge amount of…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Lintao Zhang , Jinjian Wu , Lihong Wang , Li Wang , David C. Steffens , Shijun Qiu , Guy G. Potter , Mingxia Liu

Intrinsic brain activity is characterized by highly structured co-activations between different regions, whose origin is still under debate. In this paper, we address the question whether it is possible to unveil how the underlying…

Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

Computational Engineering, Finance, and Science · Computer Science 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

Understanding the operation of biological and artificial networks remains a difficult and important challenge. To identify general principles, researchers are increasingly interested in surveying large collections of networks that are…

Machine Learning · Statistics 2022-01-14 Alex H. Williams , Erin Kunz , Simon Kornblith , Scott W. Linderman

Neurophysiological decoding, fundamental to advancing brain-computer interface (BCI) technologies, has significantly benefited from recent advances in deep learning. However, existing decoding approaches largely remain constrained to…

Signal Processing · Electrical Eng. & Systems 2025-08-07 Di Wu , Yifei Jia , Siyuan Li , Shiqi Zhao , Jie Yang , Mohamad Sawan

Understanding the common topological characteristics of the human brain network across a population is central to understanding brain functions. The abstraction of human connectome as a graph has been pivotal in gaining insights on the…

Quantitative Methods · Quantitative Biology 2023-04-26 Soumya Das , D. Vijay Anand , Moo K. Chung

Normative modeling enables individualized characterization of structural brain deviations by evaluating subjects against a reference population rather than a group average. Most existing implementations treat brain regions independently and…

Methodology · Statistics 2026-05-19 J. T. Korley

Brain aging is a widely studied longitudinal process throughout which the brain undergoes considerable morphological changes and various machine learning approaches have been proposed to analyze it. Within this context, brain age prediction…

Computer Vision and Pattern Recognition · Computer Science 2020-11-30 Matthias Wilms , Jordan J. Bannister , Pauline Mouches , M. Ethan MacDonald , Deepthi Rajashekar , Sönke Langner , Nils D. Forkert

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Although numerous studies report significant sex differences in functional connectivity, these differences do not sufficient to reveal specific functional disparities among brain regions or the topological differences in brain networks.…

Quantitative Methods · Quantitative Biology 2024-10-10 Wenyu Chen , Ling Zhan , Yunsong Luo , Jiang Qiu , Tao Jia