Related papers: Modeling the distribution of insulin in pancreas
Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon…
A variety of oscillations are observed in pancreatic islets.We establish a model, incorporating two oscillatory systems of different time scales: One is the well-known bursting model in pancreatic beta-cells and the other is the…
Glucose homeostasis is controlled by the islets of Langerhans which are equipped with alpha-cells increasing the blood glucose level, beta-cells decreasing it, and delta-cells the precise role of which still needs identifying. Although…
Diabetes cases worldwide have risen steadily over the past decades, lending urgency to the search for more efficient, effective, and personalized ways to treat the disease. Current treatment strategies, however, may fail to maintain…
Major part of a pancreatic islet is composed of beta cells that secrete insulin, a key hormone regulating influx of nutrients into all cells in a vertebrate organism to support nutrition, housekeeping or energy storage. Beta cells…
Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…
We investigate intercellular insulin dynamics in an array of diffusively coupled pancreatic islet \b{eta}-cells. The cells are connected via gap junction coupling, where nearest neighbor interactions are included. Through the multiple scale…
Pancreatic islets, controlling glucose homeostasis, consist of \alpha, \beta, and \delta\ cells. It has been observed that \alpha\ and \beta\ cells generate out-of-phase synchronization in the release of glucagon and insulin,…
Diabetes is a civilization chronic disease characterized by a constant elevated concentration of glucose in the blood. Many processes are involved in the glucose regulation, and their interactions are very complex. To better understand…
Pancreatic $\beta$-cells play a central role in maintaining glucose homeostasis through the pulsatile secretion of insulin. This essential function relies not only on intracellular regulatory mechanisms but also on coordinated interactions…
Cells of almost all solid tissues are connected with gap junctions which permit the direct transfer of ions and small molecules, integral to regulating coordinated function in the tissue. The pancreatic islets of Langerhans are responsible…
Diabetes mellitus is a global health crisis characterized by poor blood sugar regulation, impacting millions of people worldwide and leading to severe complications and mortality. Although Type 1 Diabetes Mellitus (T1DM) has a lower number…
Diabetes, a chronic condition that impairs how the body turns food into energy, i.e. blood glucose, affects 38 million people in the US alone. The standard treatment is to supplement carbohydrate intake with an artificial pancreas, i.e. a…
Calcium signals in pancreatic beta-cells collectives show a sharp transition from uncorrelated to correlated state resembling a phase transition as the slowly increasing glucose concentration crosses the tipping point. However, the exact…
People with diabetes need insulin delivery to effectively manage their blood glucose levels, especially after meals, because their bodies either do not produce enough insulin or cannot fully utilize it. Accurate insulin delivery starts with…
Diabetes mellitus is a disease that affects to hundreds of millions of people worldwide. Maintaining a good control of the disease is critical to avoid severe long-term complications. In recent years, several artificial pancreas systems…
Pancreatic $\beta-$cells regulate insulin secretion through complex oscillations, which are vital for glucose control and diabetes research. In this paper, an existing mathematical model of $\beta-$cell dynamics is analyzed using a…
Type 2 diabetes (T2D) is a challenging metabolic disorder characterized by a substantial loss of $\beta$-cell mass and alteration of $\beta$-cell function in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis.…
Beta cells in pancreas represent an example of coupled biological oscillators which via communication pathways, are able to synchronize their electrical activity, giving rise to pulsatile insulin release. In this work we numerically analyze…
Even within small organs like pancreatic islets, different endocrine cell types and subtypes form a heterogeneous collective to sense the chemical composition of the extracellular solution and compute an adequate hormonal output. Erroneous…