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Cancer is an epidemic worldwide. At present one in four persons has cancer and this statistic will change to one in a two person in the near future. It is now known that war against cancer is the early, curable detection and treatment.…

Tissues and Organs · Quantitative Biology 2017-10-03 Shiva Bhandari , Sri Choudannavar , Ethan Avery , Peeyush Sahay , Prabhakar Pradhan

Angiogenesis, the formation of new vessels, is one of the key mechanisms in tumor development and an appealing target for therapy. Non-invasive, high-resolution, high sensitivity, quantitative 3D imaging techniques are required to correctly…

Image and Video Processing · Electrical Eng. & Systems 2019-12-06 Charlie Demené , Thomas Payen , Alexandre Dizeux , Guillaume Barrois , Jean-Luc Gennisson , Lori Bridal , Mickael Tanter

Analysis of cancer and other pathological diseases, like the interstitial lung diseases (ILDs), is usually possible through Computed Tomography (CT) scans. To aid this, a preprocessing step of segmentation is performed to reduce the area to…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Jeovane Honório Alves , Pedro Martins Moreira Neto , Lucas Ferrari de Oliveira

Lung cancer has been one of the leading causes of cancer-related deaths worldwide for years. With the emergence of deep learning, computer-assisted diagnosis (CAD) models based on learning algorithms can accelerate the nodule screening…

Image and Video Processing · Electrical Eng. & Systems 2023-05-03 Xuan Zhao , Benjamin Hou

The distribution of produced isotopes during proton therapy can be imaged with Positron Emission Tomography (PET) to verify dose delivery. However, biological washout, driven by tissue-dependent processes such as perfusion and cellular…

The objective of this study was to develop a PET tumor-segmentation framework that addresses the challenges of limited spatial resolution, high image noise, and lack of clinical training data with ground-truth tumor boundaries in PET…

Characterization of lung nodules as benign or malignant is one of the most important tasks in lung cancer diagnosis, staging and treatment planning. While the variation in the appearance of the nodules remains large, there is a need for a…

Computer Vision and Pattern Recognition · Computer Science 2018-10-18 Sarfaraz Hussein , Robert Gillies , Kunlin Cao , Qi Song , Ulas Bagci

Accurate evaluation of regional lung ventilation is essential for the management and treatment of lung cancer patients, supporting assessments of pulmonary function, optimization of therapeutic strategies, and monitoring of treatment…

Medical Physics · Physics 2025-07-22 Rihui Zhang , Haiming Zhu , Jingtong Zhao , Lei Zhang , Fang-Fang Yin , Chunhao Wang , Zhenyu Yang

In this paper, we would like to quantitatively measure the tumor volume contained in the breast imaged by the Digital Breast Tomosynthesis (DBT), a reconstructed 3D image. The estimated volume will add to the prognostic value of risk…

Medical Physics · Physics 2018-04-17 Bocar Wane

The distribution of absorbed dose in radionuclide therapy with Lu$^{177}$ can be approximated by convolving an image of the time-integrated activity distribution with a dose voxel kernel representing different tissue types. This fast but…

Machine Learning · Statistics 2026-03-25 Luciano Melodia

Digital analysis of mammographic images is a complementary tool to clinical evaluation, commonly used to identify tumors and/or microcalcifications in mammograms. Recent mammographic equipment, can automatically classify them using this…

We present cytometric classification of live healthy and cancer cells by using the spatial morphological and textural information found in the label-free quantitative phase images of the cells. We compare both healthy cells to primary tumor…

Quantitative Methods · Quantitative Biology 2020-01-23 Darina Roitshtain , Lauren Wolbromsky , Evgeny Bal , Hayit Greenspan , Lisa L. Satterwhite , Natan T. Shaked

Lung cancer, particularly in its advanced stages, remains a leading cause of death globally. Though early detection via low-dose computed tomography (CT) is promising, the identification of high-risk factors crucial for surgical mode…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Xiaotong Fu , Xiangyu Meng , Jing Zhou , Ying Ji

The performance of a computer-aided automated diagnosis system of lung cancer from Computed Tomography (CT) volumetric images greatly depends on the accurate detection and segmentation of tumor regions. In this paper, we present Recurrent…

Image and Video Processing · Electrical Eng. & Systems 2020-09-09 Uday Kamal , Abdul Muntakim Rafi , Rakibul Hoque , Jonathan Wu , Md. Kamrul Hasan

Background: Voxel-based analysis (VBA) for population level radiotherapy (RT) outcomes modeling requires topology preserving inter-patient deformable image registration (DIR) that preserves tumors on moving images while avoiding unrealistic…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Jue Jiang , Chloe Min Seo Choi , Maria Thor , Joseph O. Deasy , Harini Veeraraghavan

We propose a statistical framework to integrate radiological magnetic resonance imaging (MRI) and genomic data to identify the underlying radiogenomic associations in lower grade gliomas (LGG). We devise a novel imaging phenotype by…

Lung cancer is the leading cause of cancer death and early diagnosis is associated with a positive prognosis. Chest X-ray (CXR) provides an inexpensive imaging mode for lung cancer diagnosis. Suspicious nodules are difficult to distinguish…

Image and Video Processing · Electrical Eng. & Systems 2023-07-14 Michael James Horry , Subrata Chakraborty , Biswajeet Pradhan , Manoranjan Paul , Jing Zhu , Prabal Datta Barua , U. Rajendra Acharya , Fang Chen , Jianlong Zhou

Diffusing alpha-emitters radiation therapy (Alpha-DaRT) is a new modality that uses alpha particles to treat solid tumors. Alpha-DaRT employs interstitial sources loaded with low activities of Radium-224, which release a chain of…

Background and Objective:Computer-aided diagnosis (CAD) systems promote diagnosis effectiveness and alleviate pressure of radiologists. A CAD system for lung cancer diagnosis includes nodule candidate detection and nodule malignancy…

Image and Video Processing · Electrical Eng. & Systems 2022-01-17 Shaohua Zheng , Zhiqiang Shen , Chenhao Peia , Wangbin Ding , Haojin Lin , Jiepeng Zheng , Lin Pan , Bin Zheng , Liqin Huang

Publicly available, large-scale medical imaging datasets are crucial for developing and validating artificial intelligence models and conducting retrospective clinical research. However, datasets that combine functional and anatomical…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Le Xue , Gang Feng , Wenbo Zhang , Yichi Zhang , Lanlan Li , Shuqi Wang , Liling Peng , Sisi Peng , Xin Gao