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Histopathological images are essential for medical diagnosis and treatment planning, but interpreting them accurately using machine learning can be challenging due to variations in tissue preparation, staining and imaging protocols. Domain…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Vaibhav Khamankar , Sutanu Bera , Saumik Bhattacharya , Debashis Sen , Prabir Kumar Biswas

Medical images are usually collected from multiple domains, leading to domain shifts that impair the performance of medical image segmentation models. Domain Generalization (DG) aims to address this issue by training a robust model with…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Xi Chen , Zhiqiang Shen , Peng Cao , Jinzhu Yang , Osmar R. Zaiane

Deep neural networks often suffer performance drops when test data distribution differs from training data. Domain Generalization (DG) aims to address this by focusing on domain-invariant features or augmenting data for greater diversity.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Nam Duong Tran , Nam Nguyen Phuong , Hieu H. Pham , Phi Le Nguyen , My T. Thai

Though convolutional neural networks (CNNs) have demonstrated remarkable ability in learning discriminative features, they often generalize poorly to unseen domains. Domain generalization aims to address this problem by learning from a set…

Computer Vision and Pattern Recognition · Computer Science 2021-04-06 Kaiyang Zhou , Yongxin Yang , Yu Qiao , Tao Xiang

Deep learning (DL)-based models have demonstrated good performance in medical image segmentation. However, the models trained on a known dataset often fail when performed on an unseen dataset collected from different centers, vendors and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Lei Li , Veronika A. Zimmer , Wangbin Ding , Fuping Wu , Liqin Huang , Julia A. Schnabel , Xiahai Zhuang

Despite being very powerful in standard learning settings, deep learning models can be extremely brittle when deployed in scenarios different from those on which they were trained. Domain generalization methods investigate this problem and…

Computer Vision and Pattern Recognition · Computer Science 2021-01-28 Francesco Cappio Borlino , Antonio D'Innocente , Tatiana Tommasi

In this paper, we consider the problem of domain generalization in semantic segmentation, which aims to learn a robust model using only labeled synthetic (source) data. The model is expected to perform well on unseen real (target) domains.…

Computer Vision and Pattern Recognition · Computer Science 2022-10-14 Zhun Zhong , Yuyang Zhao , Gim Hee Lee , Nicu Sebe

As a recent noticeable topic, domain generalization (DG) aims to first learn a generic model on multiple source domains and then directly generalize to an arbitrary unseen target domain without any additional adaption. In previous DG…

Computer Vision and Pattern Recognition · Computer Science 2022-02-17 Yue Wang , Lei Qi , Yinghuan Shi , Yang Gao

Recent advances in deep learning for medical image segmentation demonstrate expert-level accuracy. However, in clinically realistic environments, such methods have marginal performance due to differences in image domains, including…

Computer Vision and Pattern Recognition · Computer Science 2019-06-13 Ling Zhang , Xiaosong Wang , Dong Yang , Thomas Sanford , Stephanie Harmon , Baris Turkbey , Holger Roth , Andriy Myronenko , Daguang Xu , Ziyue Xu

Deep learning models usually suffer from domain shift issues, where models trained on one source domain do not generalize well to other unseen domains. In this work, we investigate the single-source domain generalization problem: training a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-24 Cheng Ouyang , Chen Chen , Surui Li , Zeju Li , Chen Qin , Wenjia Bai , Daniel Rueckert

Convolutional Neural Networks (CNNs) show impressive performance in the standard classification setting where training and testing data are drawn i.i.d. from a given domain. However, CNNs do not readily generalize to new domains with…

Computer Vision and Pattern Recognition · Computer Science 2020-07-13 Nathan Somavarapu , Chih-Yao Ma , Zsolt Kira

Clinical machine learning models experience significantly degraded performance in datasets not seen during training, e.g., new hospitals or populations. Recent developments in domain generalization offer a promising solution to this problem…

Machine Learning · Computer Science 2021-04-16 Haoran Zhang , Natalie Dullerud , Laleh Seyyed-Kalantari , Quaid Morris , Shalmali Joshi , Marzyeh Ghassemi

For medical image segmentation, imagine if a model was only trained using MR images in source domain, how about its performance to directly segment CT images in target domain? This setting, namely generalizable cross-modality segmentation,…

Computer Vision and Pattern Recognition · Computer Science 2022-03-29 Ziqi Zhou , Lei Qi , Xin Yang , Dong Ni , Yinghuan Shi

Neural networks do not generalize well to unseen data with domain shifts -- a longstanding problem in machine learning and AI. To overcome the problem, we propose MixStyle, a simple plug-and-play, parameter-free module that can improve…

Computer Vision and Pattern Recognition · Computer Science 2023-09-18 Kaiyang Zhou , Yongxin Yang , Yu Qiao , Tao Xiang

Traditional domain generalization methods often rely on domain alignment to reduce inter-domain distribution differences and learn domain-invariant representations. However, domain shifts are inherently difficult to eliminate, which limits…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Yuheng Xu , Taiping Zhang

Accurate medical image segmentation is essential for effective diagnosis and treatment planning but is often challenged by domain shifts caused by variations in imaging devices, acquisition conditions, and patient-specific attributes.…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Jie Bao , Zhixin Zhou , Wen Jung Li , Rui Luo

Domain generalization is a technique aimed at enabling models to maintain high accuracy when applied to new environments or datasets (unseen domains) that differ from the datasets used in training. Generally, the accuracy of models trained…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Reiji Saito , Kazuhiro Hotta

Domain generalization (DG) approaches intend to extract domain invariant features that can lead to a more robust deep learning model. In this regard, style augmentation is a strong DG method taking advantage of instance-specific feature…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Zheyuan Zhang , Bin Wang , Debesh Jha , Ugur Demir , Ulas Bagci

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

Domain generalization (DG) has been a hot topic in image recognition, with a goal to train a general model that can perform well on unseen domains. Recently, federated learning (FL), an emerging machine learning paradigm to train a global…

Computer Vision and Pattern Recognition · Computer Science 2022-10-04 Junming Chen , Meirui Jiang , Qi Dou , Qifeng Chen
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