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Network models provide a powerful framework for analysing single-cell count data, facilitating the characterisation of cellular identities, disease mechanisms, and developmental trajectories. However, uncertainty modeling in unsupervised…

Genomics · Quantitative Biology 2026-04-27 Shanshan Ren , Thomas E. Bartlett , Lina Gerontogianni , Swati Chandna

This work focuses on clustering populations with a hierarchical dependency structure that can be described by a tree. A particular example that is the focus of our work is the phylogenetic tree, with nodes often representing biological…

Methodology · Statistics 2023-02-28 Hanxi Sun , Heejung Shim , Vinayak Rao

In the quest to improve efficiency, interdependence and complexity are becoming defining characteristics of modern complex networks representing engineered and natural systems. Graph theory is a widely used framework for modeling such…

Social and Information Networks · Computer Science 2022-05-31 Sai Munikoti , Laya Das , Balasubramaniam Natarajan

Bayesian Networks (BNs) have become increasingly popular over the last few decades as a tool for reasoning under uncertainty in fields as diverse as medicine, biology, epidemiology, economics and the social sciences. This is especially true…

Machine Learning · Computer Science 2022-10-27 Neville K. Kitson , Anthony C. Constantinou , Zhigao Guo , Yang Liu , Kiattikun Chobtham

In this paper, I outline several conceptual and methodological issues related to modeling individual and group processes embedded in clustered/hierarchical data structures. We position multilevel modeling techniques within a broader set of…

Methodology · Statistics 2022-12-29 Amira Ibrahim El-Desokey

This paper proposes a hierarchical Bayesian multitask learning model that is applicable to the general multi-task binary classification learning problem where the model assumes a shared sparsity structure across different tasks. We derive a…

A general Bayesian framework for model selection on random network models regarding their features is considered. The goal is to develop a principle Bayesian model selection approach to compare different fittable, not necessarily nested,…

Methodology · Statistics 2020-04-30 Papamichalis Marios

We introduce a new method for learning Bayesian neural networks, treating them as a stack of multivariate Bayesian linear regression models. The main idea is to infer the layerwise posterior exactly if we know the target outputs of each…

Machine Learning · Computer Science 2024-11-20 Richard Kurle , Alexej Klushyn , Ralf Herbrich

Bayesian graphical models are powerful tools to infer complex relationships in high dimension, yet are often fraught with computational and statistical challenges. If exploited in a principled way, the increasing information collected…

Methodology · Statistics 2024-03-15 Xiaoyue Xi , Hélène Ruffieux

Layered neural networks have greatly improved the performance of various applications including image processing, speech recognition, natural language processing, and bioinformatics. However, it is still difficult to discover or interpret…

Machine Learning · Statistics 2017-10-05 Chihiro Watanabe , Kaoru Hiramatsu , Kunio Kashino

Network data arises through observation of relational information between a collection of entities. Recent work in the literature has independently considered when (i) one observes a sample of networks, connectome data in neuroscience being…

Methodology · Statistics 2022-06-22 George Bolt , Simón Lunagómez , Christopher Nemeth

The massively parallel nature of biological information processing plays an important role for its superiority to human-engineered computing devices. In particular, it may hold the key to overcoming the von Neumann bottleneck that limits…

Brain connectivity analysis based on magnetic resonance imaging is crucial for understanding neurological mechanisms. However, edge-based connectivity inference faces significant challenges, particularly the curse of dimensionality when…

Methodology · Statistics 2025-12-23 Zijing Li , Chenhao Zeng , Shufei Ge

Complex multilayer network datasets have become ubiquitous in various applications, including neuroscience, social sciences, economics, and genetics. Notable examples include brain connectivity networks collected across multiple patients or…

Social and Information Networks · Computer Science 2026-03-06 Alexander Kagan , Peter W. MacDonald , Elizaveta Levina , Ji Zhu

A Bayesian network is a graphical model that encodes probabilistic relationships among variables of interest. When used in conjunction with statistical techniques, the graphical model has several advantages for data analysis. One, because…

Machine Learning · Computer Science 2022-01-11 David Heckerman

In real world domains, most graphs naturally exhibit a hierarchical structure. However, data-driven graph generation is yet to effectively capture such structures. To address this, we propose a novel approach that recursively generates…

Machine Learning · Computer Science 2023-06-01 Mahdi Karami , Jun Luo

Motivation: Several different threads of research have been proposed for modeling and mining temporal data. On the one hand, approaches such as dynamic Bayesian networks (DBNs) provide a formal probabilistic basis to model relationships…

Machine Learning · Computer Science 2009-04-15 Debprakash Patnaik , Srivatsan Laxman , Naren Ramakrishnan

Complex systems are often driven by higher-order interactions among multiple units, naturally represented as hypergraphs. Understanding dependency structures within these hypergraphs is crucial for understanding and predicting the behavior…

Social and Information Networks · Computer Science 2025-05-29 John Hood , Caterina De Bacco , Aaron Schein

The increasing prevalence of multiplex networks has spurred a critical need to take into account potential dependencies across different layers, especially when the goal is community detection, which is a fundamental learning task in…

Applications · Statistics 2024-09-19 Zhumengmeng Jin , Juan Sosa , Shangchen Song , Brenda Betancourt

Brain function is organized in coordinated modes of spatio-temporal activity (functional networks) exhibiting an intrinsic baseline structure with variations under different experimental conditions. Existing approaches for uncovering such…

Methodology · Statistics 2019-02-13 Joshua Lukemire , Suprateek Kundu , Giuseppe Pagnoni , Ying Guo
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