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Quantitative Structure-Property Relationship (QSPR) analysis plays a crucial role in predicting physicochemical properties and biological activities of pharmaceutical compounds, aiding in drug design and optimization. This study focuses on…

Biomolecules · Quantitative Biology 2025-03-21 Sezer Sorgun , Kahraman Birgin

A topological index of a graph $G$ is a numerical quantity that describes its topology. Reverse degree-based topological indices play an important role in finding topological descriptors. Azacitidine, Decitabine, and Guadecitabine are…

Biomolecules · Quantitative Biology 2024-04-01 H. M. Nagesh

The theory of symmetry indicators has enabled database searches for topological materials in normal conducting phases, which has led to several encyclopedic topological material databases. To date, such a database for topological…

Superconductivity · Physics 2022-07-07 Feng Tang , Seishiro Ono , Xiangang Wan , Haruki Watanabe

Considerable evidence suggests that variations in the properties of topological insulators (TIs) at the nanoscale and at interfaces can strongly affect the physics of topological materials. Therefore, a detailed understanding of surface…

InteGriTy is a software package that performs topological analysis following AIM approach on electron densities given on 3D grids. Use of tricubic interpolation is made to get the density, its gradient and hessian matrix at any required…

Chemical Physics · Physics 2007-05-23 C. Katan , P. Rabiller , C. Lecomte , M. Guezo , V. Oison , M. Souhassou

Entropy metrics (for example, permutation entropy) are nonlinear measures of irregularity in time series (one-dimensional data). Some of these entropy metrics can be generalised to data on periodic structures such as a grid or lattice…

Combinatorics · Mathematics 2021-10-22 John Stewart Fabila-Carrasco , Chao Tan , Javier Escudero

Topological indices are molecular descriptors that describe the properties of chemical compounds. These topological indices correlate specific physico-chemical properties like boiling point, enthalpy of vaporization, strain energy, and…

Combinatorics · Mathematics 2022-10-05 Haritha T , Chithra A. V.

Graph Neural Networks (GNNs) have achieved strong results in molecular property prediction, but polymers present distinct challenges: labeled datasets are scarce and small (typically in the order of hundreds of polymers) due to the need for…

Identifying the status of individual network units is critical for understanding the mechanism of convolutional neural networks (CNNs). However, it is still challenging to reliably give a general indication of unit status, especially for…

Computer Vision and Pattern Recognition · Computer Science 2022-03-18 Yang Zhao , Hao Zhang

Topological data analysis is an emerging mathematical concept for characterizing shapes in multi-scale data. In this field, persistence diagrams are widely used as a descriptor of the input data, and can distinguish robust and noisy…

Machine Learning · Statistics 2017-06-13 Genki Kusano , Kenji Fukumizu , Yasuaki Hiraoka

Topological materials are characterized by integer invariants that underpin their robust quantized electronic features, as famously exemplified by the Chern number in the integer quantum Hall effect. Yet, in most candidate systems, the…

Mesoscale and Nanoscale Physics · Physics 2025-08-27 Yuval Abulafia , Eric Akkermans

A topological index reflects the physical, chemical and structural properties of a molecule, and its study has an important role in molecular topology, chemical graph theory and mathematical chemistry. It is a natural problem to…

Combinatorics · Mathematics 2022-07-08 Rui Song , Qiongxiang Huang

A central issue of the science of complex systems is the quantitative characterization of complexity. In the present work we address this issue by resorting to information geometry. Actually we propose a constructive way to associate to a -…

Mathematical Physics · Physics 2017-12-19 Roberto Franzosi , Domenico Felice , Stefano Mancini , Marco Pettini

In recent years, kernel methods are widespread in tasks of similarity measuring. Specifically, graph kernels are widely used in fields of bioinformatics, chemistry and financial data analysis. However, existing methods, especially entropy…

Machine Learning · Computer Science 2023-03-27 Chengyu Sun , Xing Ai , Zhihong Zhang , Edwin R Hancock

This work aims to assess the molecular architectures of anti-tuberculosis drugs using both degree-based topological indices and novel distance based indices. We can represent the chemical arrangement as a graph, with atoms serving as the…

Biomolecules · Quantitative Biology 2024-11-06 D. C. Gunawardhana , G. H. J. Lanel , K. K. K. R. Perera , A. G. M. J. Gunaratna

In many areas such as computational biology, finance or social sciences, knowledge of an underlying graph explaining the interactions between agents is of paramount importance but still challenging. Considering that these interactions may…

Signal Processing · Electrical Eng. & Systems 2021-04-29 Mircea Moscu , Ricardo A. Borsoi , Cédric Richard , José-Carlos M. Bermudez

Recent advances in molecular representation learning have produced highly effective encodings of molecules for numerous cheminformatics and bioinformatics tasks. However, extracting general chemical insight while balancing predictive…

Machine Learning · Computer Science 2025-09-26 Rahul Khorana

We show that the von Neumann entropy (from herein referred to as the von Neumann index) of a graph's trace normalized combinatorial Laplacian provides structural information about the level of centralization across a graph. This is done by…

Information Theory · Computer Science 2018-02-06 David Simmons , Justin Coon , Animesh Datta

Topology concepts have significantly deepened of our understanding in recent years of the electronic properties of one-dimensional (1D) nano structures such as the graphene nanoribbons. Controlling topological electronic properties of GNRs…

Materials Science · Physics 2021-02-03 Jingwei Jiang , Steven G. Louie

Integer-valued topological indices, characterizing nonlocal properties of quantum states of matter, are known to directly predict robust physical properties of equilibrium systems. The Chern number, e.g., determines the quantized Hall…