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To discover new drugs is to seek and to prove causality. As an emerging approach leveraging human knowledge and creativity, data, and machine intelligence, causal inference holds the promise of reducing cognitive bias and improving decision…

Quantitative Methods · Quantitative Biology 2025-04-09 Tom Michoel , Jitao David Zhang

The concept of causality has a controversial history. The question of whether it is possible to represent and address causal problems with probability theory, or if fundamentally new mathematics such as the do-calculus is required has been…

Machine Learning · Statistics 2019-10-22 Finnian Lattimore , David Rohde

There has been considerable interest in estimating heterogeneous causal effects across individuals or subpopulations. Researchers often assess causal effect heterogeneity based on the subjects' covariates using the conditional average…

Methodology · Statistics 2026-02-10 Yuta Kawakami , Jin Tian

Many natural phenomena are intrinsically causal. The discovery of the cause-effect relationships implicit in these processes can help us to understand and describe them more effectively, which boils down to causal discovery about the data…

Quantitative Methods · Quantitative Biology 2024-01-09 Jean Pierre Gomez

Decision-making under uncertainty and causal thinking are fundamental aspects of intelligent reasoning. Decision-making has been well studied when the available information is considered at the associative (probabilistic) level. The…

Artificial Intelligence · Computer Science 2026-04-30 Mauricio Gonzalez Soto , David Danks , Hugo J. Escalante Balderas , L. Enrique Sucar

Inferring causal effects of treatments is a central goal in many disciplines. The potential outcomes framework is a main statistical approach to causal inference, in which a causal effect is defined as a comparison of the potential outcomes…

Methodology · Statistics 2018-01-04 Peng Ding , Fan Li

We present a basis for studying questions of cause and effect in statistics which subsumes and reconciles the models proposed by Pearl, Robins, Rubin and others, and which, as far as mathematical notions and notation are concerned, is…

Statistics Theory · Mathematics 2023-04-18 José A. Ferreira

Typical causal effects are defined based on the marginal distribution of potential outcomes. However, many real-world applications require causal estimands involving the joint distribution of potential outcomes to enable more nuanced…

Methodology · Statistics 2026-04-17 Peng Wu , Xiaojie Mao

Conditional density estimation (CDE) models can be useful for many statistical applications, especially because the full conditional density is estimated instead of traditional regression point estimates, revealing more information about…

Methodology · Statistics 2021-07-12 Alex Akira Okuno , Felipe Maia Polo

We study the estimation of causal estimand involving the joint distribution of treatment and control outcomes for a single unit. In typical causal inference settings, it is impossible to observe both outcomes simultaneously, which places…

Methodology · Statistics 2026-02-16 Sirui Lin , Zijun Gao , Jose Blanchet , Peter Glynn

Recently, interest has grown in the use of proxy variables of unobserved confounding for inferring the causal effect in the presence of unmeasured confounders from observational data. One difficulty inhibiting the practical use is finding…

Machine Learning · Computer Science 2024-05-28 Feng Xie , Zhengming Chen , Shanshan Luo , Wang Miao , Ruichu Cai , Zhi Geng

The purpose of this paper is to introduce a notion of causality in Markov decision processes based on the probability-raising principle and to analyze its algorithmic properties. The latter includes algorithms for checking cause-effect…

Logic in Computer Science · Computer Science 2022-01-24 Christel Baier , Florian Funke , Jakob Piribauer , Robin Ziemek

Causal inference in completely randomized treatment-control studies with binary outcomes is discussed from Fisherian, Neymanian and Bayesian perspectives, using the potential outcomes framework. A randomization-based justification of…

Statistics Theory · Mathematics 2015-01-13 Peng Ding , Tirthankar Dasgupta

The most widely discussed methods for estimating the Average Causal Effect/Average Treatment Effect are those for intervention in discrete binary variables whose value represents intervention/non-intervention groups. On the other hand,…

Machine Learning · Statistics 2022-03-21 Yoshiaki Kitazawa

We present a symbolic machinery that admits both probabilistic and causal information about a given domain and produces probabilistic statements about the effect of actions and the impact of observations. The calculus admits two types of…

Artificial Intelligence · Computer Science 2013-02-28 Judea Pearl

We present the language {m P}{cal C}+ for probabilistic reasoning about actions, which is a generalization of the action language {cal C}+ that allows to deal with probabilistic as well as nondeterministic effects of actions. We define a…

Artificial Intelligence · Computer Science 2012-12-12 Thomas Eiter , Thomas Lukasiewicz

We introduce computational causal inference as an interdisciplinary field across causal inference, algorithms design and numerical computing. The field aims to develop software specializing in causal inference that can analyze massive…

Computation · Statistics 2020-07-22 Jeffrey C. Wong

Probabilities of causation play a crucial role in modern decision-making. This paper addresses the challenge of predicting probabilities of causation for subpopulations with insufficient data using machine learning models. Tian and Pearl…

Artificial Intelligence · Computer Science 2025-02-14 Shuai Wang , Ang Li

In prior work we have introduced an asymptotic threshold of sufficient randomness for causal inference from observational data. In this paper we extend that prior work in three main ways. First, we show how to empirically estimate a lower…

Methodology · Statistics 2023-09-07 Brian Knaeble , Braxton Osting , Placede Tshiaba

In causal models, a given mechanism is assumed to be invariant to changes of other mechanisms. While this principle has been utilized for inference in settings where the causal variables are observed, theoretical insights when the variables…

Machine Learning · Statistics 2023-12-07 Simon Bing , Jonas Wahl , Urmi Ninad , Jakob Runge