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Many diagnostic errors occur because clinicians cannot easily access relevant information in patient Electronic Health Records (EHRs). In this work we propose a method to use LLMs to identify pieces of evidence in patient EHR data that…

Studying the relationship between neuroanatomy and cognitive decline due to Alzheimer's has been a major research focus in the last decade. However, to infer cause-effect relationships rather than simple associations from observational…

Methodology · Statistics 2021-06-22 Sebastian Pölsterl , Christian Wachinger

Deep neural networks (DNN) has received increasing attention in machine learning applications in the last several years. Recently, a non-asymptotic error bound has been developed to measure the performance of the fully connected DNN…

Machine Learning · Statistics 2024-05-15 Kejin Wu , Dimitris N. Politis

Functional MRI (fMRI) and single-cell transcriptomics are pivotal in Alzheimer's disease (AD) research, each providing unique insights into neural function and molecular mechanisms. However, integrating these complementary modalities…

Quantitative Methods · Quantitative Biology 2025-02-06 Yu-An Huang , Yao Hu , Yue-Chao Li , Xiyue Cao , Xinyuan Li , Kay Chen Tan , Zhu-Hong You , Zhi-An Huang

Machine learning (ML) has shown great promise for revolutionizing a number of areas, including healthcare. However, it is also facing a reproducibility crisis, especially in medicine. ML models that are carefully constructed from and…

Machine Learning · Computer Science 2024-09-16 Rongguang Wang , Guray Erus , Pratik Chaudhari , Christos Davatzikos

In clinical data sets we often find static information (e.g. patient gender, blood type, etc.) combined with sequences of data that are recorded during multiple hospital visits (e.g. medications prescribed, tests performed, etc.). Recurrent…

Machine Learning · Computer Science 2016-11-18 Cristóbal Esteban , Oliver Staeck , Yinchong Yang , Volker Tresp

In recent years, deep learning models have been applied to neuroimaging data for early diagnosis of Alzheimer's disease (AD). Structural magnetic resonance imaging (sMRI) and positron emission tomography (PET) images provide structural and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Yanteng Zhanga , Xiaohai He , Yi Hao Chan , Qizhi Teng , Jagath C. Rajapakse

Diagnosis prediction is a critical task in healthcare, where timely and accurate identification of medical conditions can significantly impact patient outcomes. Traditional machine learning and deep learning models have achieved notable…

Machine Learning · Computer Science 2025-01-09 Qiuhao Lu , Rui Li , Elham Sagheb , Andrew Wen , Jinlian Wang , Liwei Wang , Jungwei W. Fan , Hongfang Liu

Convolutional neural networks (CNN) have become a powerful tool for detecting patterns in image data. Recent papers report promising results in the domain of disease detection using brain MRI data. Despite the high accuracy obtained from…

Image and Video Processing · Electrical Eng. & Systems 2020-08-19 Arjun Haridas Pallath , Martin Dyrba

Multimodal data analysis can lead to more accurate diagnoses of brain disorders due to the complementary information that each modality adds. However, a major challenge of using multimodal datasets in the neuroimaging field is incomplete…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Reihaneh Hassanzadeh , Anees Abrol , Hamid Reza Hassanzadeh , Vince D. Calhoun

Alzheimer's Disease (AD) is a non-curable progressive neurodegenerative disorder that affects the human brain, leading to a decline in memory, cognitive abilities, and eventually, the ability to carry out daily tasks. Manual diagnosis of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Santanu Roy , Archit Gupta , Shubhi Tiwari , Palak Sahu

Understanding the relationship between cognition and intrinsic brain activity through purely data-driven approaches remains a significant challenge in neuroscience. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a…

Machine Learning · Computer Science 2024-11-01 Yutong Gao , Vince D. Calhoun , Robyn L. Miller

Dementia is a complex syndrome impacting cognitive and emotional functions, with Alzheimer's disease being the most common form. This study focuses on enhancing dementia prediction using machine learning (ML) techniques on patient health…

Artificial Intelligence · Computer Science 2026-01-13 Shafiul Ajam Opee , Nafiz Fahad , Anik Sen , Rasel Ahmed , Fariha Jahan , Md. Kishor Morol , Md Rashedul Islam

The Transductive Confidence Machine Nearest Neighbours (TCMNN) algorithm and a supporting, simple user interface was developed. Different settings of the TCMNN algorithms' parameters were tested on medical data sets, in addition to the use…

Machine Learning · Computer Science 2024-05-28 David Lindsay

Neuropsychiatric symptoms (NPS) such as depression and apathy are common in Alzheimer's disease (AD) and often precede cognitive decline. NPS assessments hold promise as early detection markers due to their correlation with disease…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Synne Hjertager Osenbroch , Lisa Ramona Rosvold , Yao Lu , Alvaro Fernandez-Quilez

Early diagnosis of Alzheimer's Disease (AD) faces multiple data-related challenges, including high variability in patient data, limited access to specialized diagnostic tests, and overreliance on single-type indicators. These challenges are…

Quantitative Methods · Quantitative Biology 2025-03-05 Yizong Xing , Dhita Putri Pratama , Yuke Wang , Yufan Zhang , Brian E. Chapman

Computer-aided early diagnosis of Alzheimers Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research in recent years. Some recent studies have shown promising results in the AD and…

Computer Vision and Pattern Recognition · Computer Science 2018-01-19 Alexander Khvostikov , Karim Aderghal , Jenny Benois-Pineau , Andrey Krylov , Gwenaelle Catheline

While deep neural networks (DNNs) are used for prediction, inference on DNN-estimated subject-specific means for categorical or exponential family outcomes remains underexplored. We address this by proposing a DNN estimator under…

Machine Learning · Statistics 2026-03-18 Xuran Meng , Yi Li

Randomised Controlled Trials (RCTs) are the gold standard for estimating treatment effects across many fields of science. Technology companies have adopted A/B-testing methods as a modern RCT counterpart, where end-users are randomly…

Social and Information Networks · Computer Science 2024-09-20 Olivier Jeunen

Interpretability techniques in NLP have mainly focused on understanding individual predictions using attention visualization or gradient-based saliency maps over tokens. We propose using k nearest neighbor (kNN) representations to identify…

Computation and Language · Computer Science 2020-10-20 Nazneen Fatema Rajani , Ben Krause , Wengpeng Yin , Tong Niu , Richard Socher , Caiming Xiong
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