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Mixed-integer programming (MIP) is a well-established framework for computer-aided molecular design (CAMD). By precisely encoding the molecular space and score functions, e.g., a graph neural network, the molecular design problem is…

Computational Engineering, Finance, and Science · Computer Science 2024-11-26 Shiqiang Zhang , Christian W. Feldmann , Frederik Sandfort , Miriam Mathea , Juan S. Campos , Ruth Misener

Recent advances in mathematical programming have made Mixed Integer Optimization a competitive alternative to popular regularization methods for selecting features in regression problems. The approach exhibits unquestionable foundational…

Methodology · Statistics 2019-10-01 Ana Kenney , Francesca Chiaromonte , Giovanni Felici

While mixed-integer linear programming and convex programming solvers have advanced significantly over the past several decades, solution technologies for general mixed-integer nonlinear programs (MINLPs) have yet to reach the same level of…

Optimization and Control · Mathematics 2026-04-07 Danial Davarnia , Mohammadreza Kiaghadi , Junyuan Qiu

Mixed Integer Linear Programming (MILP) is essential for modeling complex decision-making problems but faces challenges in computational tractability and requires expert formulation. Current deep learning approaches for MILP focus on…

Machine Learning · Computer Science 2025-02-24 Sirui Li , Janardhan Kulkarni , Ishai Menache , Cathy Wu , Beibin Li

Mixed-Integer Programs (MIPs) are NP-hard optimization models that arise in a broad range of decision-making applications, including finance, logistics, energy systems, and network design. Although modern commercial solvers have achieved…

Constraint Programming (CP) users need significant expertise in order to model their problems appropriately, notably to select propagators and search strategies. This puts the brakes on a broader uptake of CP. In this paper, we introduce…

Artificial Intelligence · Computer Science 2016-11-29 Thierry Petit

We consider integer programming problems with bounded general-integer variables belonging to the general class of network flow problems. For those, we computationally investigate the effect on mixed-integer linear programming (MIP) solvers…

Optimization and Control · Mathematics 2026-04-09 Pierre Bonami , Sanjeeb Dash , Anton Derkach , Andrea Lodi

This work solves suboptimal mixed-integer quadratic programs recursively for feedback control of dynamical systems. The proposed framework leverages parametric mixed-integer quadratic programming (MIQP) and hybrid systems theory to model a…

Optimization and Control · Mathematics 2025-07-04 Luke Fina , Christopher Petersen

We develop a real-time feasible mixed-integer programming-based decision making (MIP-DM) system for automated driving. Using a linear vehicle model in a road-aligned coordinate frame, the lane change constraints, collision avoidance and…

Optimization and Control · Mathematics 2023-08-22 Rien Quirynen , Sleiman Safaoui , Stefano Di Cairano

Conflict analysis has been successfully generalized from Boolean satisfiability (SAT) solving to mixed integer programming (MIP) solvers, but although MIP solvers operate with general linear inequalities, the conflict analysis in MIP has…

Optimization and Control · Mathematics 2023-07-27 Gioni Mexi , Timo Berthold , Ambros Gleixner , Jakob Nordström

For combinatorial optimization problems, model-based paradigms such as mixed-integer programming (MIP) and constraint programming (CP) aim to decouple modeling and solving a problem: the `holy grail' of declarative problem solving. We…

Artificial Intelligence · Computer Science 2026-03-13 Ryo Kuroiwa , J. Christopher Beck

Binary (0-1) integer programming (BIP) is pivotal in scientific domains requiring discrete decision-making. As the advance of AI computing, recent works explore neural network-based solvers for integer linear programming (ILP) problems.…

Machine Learning · Computer Science 2025-05-28 Sen Bai , Chunqi Yang , Xin Bai , Xin Zhang , Zhengang Jiang

In Mixed Integer Linear Programming (MIP), a (strong) backdoor is a "small" subset of an instance's integer variables with the following property: in a branch-and-bound procedure, the instance can be solved to global optimality by branching…

Artificial Intelligence · Computer Science 2022-07-11 Elias B. Khalil , Pashootan Vaezipoor , Bistra Dilkina

The SCIP Optimization Suite provides a collection of software packages for mathematical optimization centered around the constraint integer programming framework SCIP. The focus of this paper is on the role of the SCIP Optimization Suite in…

Embedding deep neural networks (NNs) into mixed-integer programs (MIPs) is attractive for decision making with learned constraints, yet state-of-the-art monolithic linearisations blow up in size and quickly become intractable. In this…

Optimization and Control · Mathematics 2025-11-13 Shuli Zeng , Sijia Zhang , Feng Wu , Shaojie Tang , Xiang-Yang Li

Multiple Constant Multiplication (MCM) over integers is a frequent operation arising in embedded systems that require highly optimized hardware. An efficient way is to replace costly generic multiplication by bit-shifts and additions, i.e.…

Hardware Architecture · Computer Science 2022-10-11 Rémi Garcia , Anastasia Volkova

In this paper, we explore model-based approach to training robust and interpretable binarized regression models for multiclass classification tasks using Mixed-Integer Programming (MIP). Our MIP model balances the optimization of prediction…

Machine Learning · Computer Science 2022-03-22 Sanjana Tule , Nhi Ha Lan Le , Buser Say

Mixed Integer Linear Programs (MILPs) are highly flexible and powerful tools for modeling and solving complex real-world combinatorial optimization problems. Recently, machine learning (ML)-guided approaches have demonstrated significant…

Artificial Intelligence · Computer Science 2025-06-13 Junyang Cai , Taoan Huang , Bistra Dilkina

Basis path testing is a cornerstone of structural testing, yet traditional automated methods, relying on greedy graph-traversal algorithms (e.g., DFS/BFS), often generate sub-optimal paths. This structural inferiority is not a trivial…

Software Engineering · Computer Science 2026-01-12 Chao Wei , Xinyi Peng , Yawen Yan , Mao Luo , Ting Cai

We propose a hierarchical architecture for efficiently computing high-quality solutions to structured mixed-integer programs (MIPs). To reduce computational effort, our approach decouples the original problem into a higher level problem and…

Optimization and Control · Mathematics 2025-12-04 Stefan Clarke , Bartolomeo Stellato