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Biomedical question answering (QA) requires accurate interpretation of complex medical knowledge. Large language models (LLMs) have shown promising capabilities in this domain, with retrieval-augmented generation (RAG) systems enhancing…

Computation and Language · Computer Science 2025-10-21 Yingpeng Ning , Yuanyuan Sun , Ling Luo , Yanhua Wang , Yuchen Pan , Hongfei Lin

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Large Language Models (LLMs) exhibit remarkable capabilities but are prone to generating inaccurate or hallucinatory responses. This limitation stems from their reliance on vast pretraining datasets, making them susceptible to errors in…

Computation and Language · Computer Science 2024-04-02 Chi-Min Chan , Chunpu Xu , Ruibin Yuan , Hongyin Luo , Wei Xue , Yike Guo , Jie Fu

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

Retrieval-augmented generation (RAG) techniques leverage the in-context learning capabilities of large language models (LLMs) to produce more accurate and relevant responses. Originating from the simple 'retrieve-then-read' approach, the…

Computation and Language · Computer Science 2024-07-16 Yunxiao Shi , Xing Zi , Zijing Shi , Haimin Zhang , Qiang Wu , Min Xu

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Despite their remarkable capabilities, large language models (LLMs) often produce responses containing factual inaccuracies due to their sole reliance on the parametric knowledge they encapsulate. Retrieval-Augmented Generation (RAG), an ad…

Computation and Language · Computer Science 2023-10-19 Akari Asai , Zeqiu Wu , Yizhong Wang , Avirup Sil , Hannaneh Hajishirzi

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Large Language Models (LLMs) are widely used in critical fields such as healthcare, education, and finance due to their remarkable proficiency in various language-related tasks. However, LLMs are prone to generating factually incorrect…

Computation and Language · Computer Science 2023-11-27 Muneeswaran I , Shreya Saxena , Siva Prasad , M V Sai Prakash , Advaith Shankar , Varun V , Vishal Vaddina , Saisubramaniam Gopalakrishnan

Retrieval-augmented generation (RAG) is increasingly recognized as an effective approach to mitigating the hallucination of large language models (LLMs) through the integration of external knowledge. While numerous efforts, most studies…

Computation and Language · Computer Science 2025-10-10 Shuo Yu , Mingyue Cheng , Qi Liu , Daoyu Wang , Jiqian Yang , Jie Ouyang , Yucong Luo , Chenyi Lei , Enhong Chen

Large Language Models (LLMs) showcase impressive capabilities but encounter challenges like hallucination, outdated knowledge, and non-transparent, untraceable reasoning processes. Retrieval-Augmented Generation (RAG) has emerged as a…

Computation and Language · Computer Science 2024-03-28 Yunfan Gao , Yun Xiong , Xinyu Gao , Kangxiang Jia , Jinliu Pan , Yuxi Bi , Yi Dai , Jiawei Sun , Meng Wang , Haofen Wang

Deploying Large Language Models (LLMs) for healthcare question answering requires robust methods to ensure accuracy and reliability. This work introduces Query-Based Retrieval Augmented Generation (QB-RAG), a framework for enhancing…

Machine Learning · Computer Science 2025-07-31 Eric Yang , Jonathan Amar , Jong Ha Lee , Bhawesh Kumar , Yugang Jia

The exponential surge in online health information, coupled with its increasing use by non-experts, highlights the pressing need for advanced Health Information Retrieval models that consider not only topical relevance but also the factual…

Information Retrieval · Computer Science 2025-02-10 Rishabh Uapadhyay , Marco Viviani

Accessing accurate medication insights is vital for enhancing patient safety, minimizing errors, and supporting clinical decision-making. However, healthcare professionals in Africa often rely on manual and time-consuming processes to…

Information Retrieval · Computer Science 2025-02-26 Axum AI , : , J. Owoyemi , S. Abubakar , A. Owoyemi , T. O. Togunwa , F. C. Madubuko , S. Oyatoye , Z. Oyetolu , K. Akyea , A. O. Mohammed , A. Adebakin

Large language models (LLMs) have shown impressive capabilities in natural language processing tasks, including dialogue generation. This research aims to conduct a novel comparative analysis of two prominent techniques, fine-tuning with…

Large language models (LLMs) struggle with the factual error during inference due to the lack of sufficient training data and the most updated knowledge, leading to the hallucination problem. Retrieval-Augmented Generation (RAG) has gained…

Information Retrieval · Computer Science 2026-01-22 Zulun Zhu , Tiancheng Huang , Kai Wang , Junda Ye , Xinghe Chen , Siqiang Luo

A Retrieval-Augmented Generation (RAG) model powered by a large language model (LLM) provides a faster and more cost-effective solution for adapting to new data and knowledge. It also delivers more specialized responses compared to…

Computation and Language · Computer Science 2025-01-29 Zheng Zheng , Xinyi Ni , Pengyu Hong

Large language models (LLMs) are very costly and inefficient to update with new information. To address this limitation, retrieval-augmented generation (RAG) has been proposed as a solution that dynamically incorporates external knowledge…

Computation and Language · Computer Science 2025-07-10 Sezen Perçin , Xin Su , Qutub Sha Syed , Phillip Howard , Aleksei Kuvshinov , Leo Schwinn , Kay-Ulrich Scholl

In the rapidly changing world of smart technology, searching for documents has become more challenging due to the rise of advanced language models. These models sometimes face difficulties, like providing inaccurate information, commonly…

Information Retrieval · Computer Science 2025-03-20 Julien Pierre Edmond Ghali , Kosuke Shima , Koichi Moriyama , Atsuko Mutoh , Nobuhiro Inuzuka