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Related papers: A SARS-CoV-2 Interaction Dataset and VHH Sequence …

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The rapid spread of the COVID-19 pandemic has resulted in an unprecedented amount of sequence data of the SARS-CoV-2 genome -- millions of sequences and counting. This amount of data, while being orders of magnitude beyond the capacity of…

Genomics · Quantitative Biology 2022-07-20 Sarwan Ali , Bikram Sahoo , Alexander Zelikovskiy , Pin-Yu Chen , Murray Patterson

Multiple sequence alignments (MSAs) of proteins encode rich biological information and have been workhorses in bioinformatic methods for tasks like protein design and protein structure prediction for decades. Recent breakthroughs like…

As a powerful all-weather Earth observation tool, synthetic aperture radar (SAR) remote sensing enables critical military reconnaissance, maritime surveillance, and infrastructure monitoring. Although Vision language models (VLMs) have made…

Computation and Language · Computer Science 2025-03-05 Zhiming Ma , Xiayang Xiao , Sihao Dong , Peidong Wang , HaiPeng Wang , Qingyun Pan

Rapid, sensitive detection of biomolecules is important for improved testing methods for viruses as well as biomarkers and environmental hormones. For example, testing for SARS-CoV-2 is essential in the fight against the COVID-19 pandemic.…

The coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, has caused 60 millions of infections and 1.38 millions of fatalities. Genomic analysis of SARS-CoV-2 can provide insights on drug design and vaccine…

Other Quantitative Biology · Quantitative Biology 2020-11-26 Changchuan Yin , Stephen S. -T. Yau

COVID-19 pandemic, is still unknown and is an important open question. There are speculations that bats are a possible origin. Likewise, there are many closely related (corona-) viruses, such as SARS, which was found to be transmitted…

Genomics · Quantitative Biology 2022-01-10 Sarwan Ali , Babatunde Bello , Prakash Chourasia , Ria Thazhe Punathil , Yijing Zhou , Murray Patterson

The pandemic prevalence of COVID-19 has become a very serious global health issue. Scientists all over the world have been heavily invested in the discovery of a drug to combat SARS-CoV-2. It has been found that RNA-dependent RNA Polymerase…

The novelty of new human coronavirus COVID-19/SARS-CoV-2 and the lack of effective drugs and vaccines gave rise to a wide variety of strategies employed to fight this worldwide pandemic. Many of these strategies rely on the repositioning of…

Molecular Networks · Quantitative Biology 2021-06-09 Giulia Fiscon , Federica Conte , Lorenzo Farina , Paola Paci

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major worldwide public health emergency that has infected over $1.5$ million people. The partially open state of S1 subunit in spike glycoprotein is considered…

Biomolecules · Quantitative Biology 2020-04-14 Hao Tian , Peng Tao

How and where proteins interface with one another can ultimately impact the proteins' functions along with a range of other biological processes. As such, precise computational methods for protein interface prediction (PIP) come highly…

Quantitative Methods · Quantitative Biology 2021-10-08 Alex Morehead , Chen Chen , Ada Sedova , Jianlin Cheng

Coronavirus disease 2019 (COVID-19) has impacted almost every part of human life worldwide, posing a massive threat to human health. There is no specific drug for COVID-19, highlighting the urgent need for the development of effective…

Genomics · Quantitative Biology 2020-12-07 Zhihan Wang , Kai Guo , Pan Gao , Qinqin Pu , Min Wu , Changlong Li , Junguk Hur

Predicting the future evolutionary trajectory of SARS-CoV-2 remains a critical challenge, particularly due to the pivotal role of spike protein mutations. It is therefore essential to develop evolutionary models capable of continuously…

Quantitative Methods · Quantitative Biology 2025-10-06 Liaofu Luo , Jun Lv

Future SARS-CoV-2 virus outbreak COVID-XX might possibly occur during the next years. However the pathology in humans is so recent that many clinical aspects, like early detection of complications, side effects after recovery or early…

Image and Video Processing · Electrical Eng. & Systems 2020-05-29 D. Gil , K. Díaz-Chito , C. Sánchez , A. Hernández-Sabaté

The infectivity of SARS-CoV-2 depends on the binding affinity of the receptor-binding domain (RBD) of the spike protein with the angiotensin converting enzyme 2 (ACE2) receptor. The calculated RBD-ACE2 binding energies indicate that the…

Biomolecules · Quantitative Biology 2022-04-28 Lin Yang , Shuai Guo , Chengyu Houc , Jiacheng Lia , Liping Shi , Chenchen Liao , Rongchun Shi , Xiaoliang Ma , Bing Zheng , Yi Fang , Lin Ye , Xiaodong He

Over the last year, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants have highlighted the importance of screening tools with high diagnostic accuracy for new illnesses such as COVID-19. To that regard, deep…

Image and Video Processing · Electrical Eng. & Systems 2022-04-26 Danilo Avola , Andrea Bacciu , Luigi Cinque , Alessio Fagioli , Marco Raoul Marini , Riccardo Taiello

Severe acute respiratory syndrome coronavirus two (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, represents an unprecedented global health challenge. Consequently, a large amount of research into…

Effective, sensitive, and reliable diagnostic reagents are of paramount importance for combating the ongoing coronavirus disease 2019 (COVID-19) pandemic at a time there is no preventive vaccine nor specific drug available for severe acute…

Genomics · Quantitative Biology 2020-05-06 Rui Wang , Yuta Hozumi , Changchuan Yin , Guo-Wei Wei

The recent zoonotic coronavirus virus outbreak of a novel type [COVID 19] has necessitated the adequate understanding of the evolutionary pathway of zoonotic viruses which adversely affects human populations for therapeutic constructs to…

Other Quantitative Biology · Quantitative Biology 2020-05-07 Adejoke Olukayode Obajuluwa , Pius Abimbola Okiki , Tiwalola Madoc Obajuluwa , Olakunle Bamikole Afolabi

The 2019 novel coronavirus (SARS-CoV-2) pandemic has resulted in more than a million deaths, high morbidities, and economic distress worldwide. There is an urgent need to identify medications that would treat and prevent novel diseases like…

Machine Learning · Computer Science 2020-12-04 Siddhant Doshi , Sundeep Prabhakar Chepuri

With the rapid global spread of COVID-19, more and more data related to this virus is becoming available, including genomic sequence data. The total number of genomic sequences that are publicly available on platforms such as GISAID is…

Genomics · Quantitative Biology 2021-11-16 Sarwan Ali , Murray Patterson
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