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Related papers: LDMol: A Text-to-Molecule Diffusion Model with Str…

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Latent diffusion models (LDMs) achieve state-of-the-art performance across various tasks, including image generation and video synthesis. However, they generally lack robustness, a limitation that remains not fully explored in current…

Machine Learning · Computer Science 2025-06-10 Boris Martirosyan , Alexey Karmanov

This work explores the challenging problem of molecule design by framing it as a conditional generative modeling task, where target biological properties or desired chemical constraints serve as conditioning variables. We propose the Latent…

Large language models (LLMs) are introducing a paradigm shift in molecular discovery by enabling text-guided interaction with chemical spaces through natural language, symbolic notations, with emerging extensions to incorporate multi-modal…

Machine Learning · Computer Science 2025-05-23 Ziqing Wang , Kexin Zhang , Zihan Zhao , Yibo Wen , Abhishek Pandey , Han Liu , Kaize Ding

We present SoundLoCD, a novel text-to-sound generation framework, which incorporates a LoRA-based conditional discrete contrastive latent diffusion model. Unlike recent large-scale sound generation models, our model can be efficiently…

Sound · Computer Science 2024-05-27 Xinlei Niu , Jing Zhang , Christian Walder , Charles Patrick Martin

Modern successes of diffusion models in learning complex, high-dimensional data distributions are attributed, in part, to their capability to construct diffusion processes with analytic transition kernels and score functions. The…

Machine Learning · Statistics 2024-03-01 Guan-Horng Liu , Tianrong Chen , Evangelos A. Theodorou , Molei Tao

Diffusion models have demonstrated high-quality performance in conditional text-to-image generation, particularly with structural cues such as edges, layouts, and depth. However, lighting conditions have received limited attention and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Ryugo Morita , Stanislav Frolov , Brian Bernhard Moser , Ko Watanabe , Riku Takahashi , Andreas Dengel

Diffusion language models intrinsically fail to capture correlations between decoded tokens, which leads to a harsh trade-off between sampling quality and throughput. To solve this issue, we propose DiLaDiff, a variant of masked diffusion…

Machine Learning · Computer Science 2026-05-25 Jean-Marie Lemercier , Tomas Geffner , Karsten Kreis , Morteza Mardani , Arash Vahdat , Ante Jukić

Transformer-based Language Models (LMs) have achieved impressive results on natural language understanding tasks, but they can also generate toxic text such as insults, threats, and profanity, limiting their real-world applications. To…

Computation and Language · Computer Science 2023-07-06 Jin Myung Kwak , Minseon Kim , Sung Ju Hwang

Discrete Diffusion Language Models progressed rapidly as an alternative to autoregressive (AR) models, motivated by their parallel generation abilities. However, for tractability, discrete diffusion models sample from a factorized…

Machine Learning · Computer Science 2026-05-19 Justin Deschenaux , Caglar Gulcehre

Diffusion models achieve state-of-the-art image generation but remain computationally costly due to iterative denoising. Latent-space models like Stable Diffusion reduce overhead yet lose fine detail, while retrieval-augmented methods…

Machine Learning · Computer Science 2025-12-23 Bilal Faye , Hanane Azzag , Mustapha Lebbah

Ligand-based drug design aims to identify novel drug candidates of similar shapes with known active molecules. In this paper, we formulated an in silico shape-conditioned molecule generation problem to generate 3D molecule structures…

Machine Learning · Computer Science 2023-10-18 Ziqi Chen , Bo Peng , Srinivasan Parthasarathy , Xia Ning

While language models have made many milestones in text inference and classification tasks, they remain susceptible to adversarial attacks that can lead to unforeseen outcomes. Existing works alleviate this problem by equipping language…

Computation and Language · Computer Science 2024-01-10 Shilong Yuan , Wei Yuan , Hongzhi Yin , Tieke He

Latent diffusion models achieve state-of-the-art performance on a variety of generative tasks, such as image synthesis and image editing. However, the robustness of latent diffusion models is not well studied. Previous works only focus on…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Jianping Zhang , Zhuoer Xu , Shiwen Cui , Changhua Meng , Weibin Wu , Michael R. Lyu

Prior masked modeling motion generation methods predominantly study text-to-motion. We present DiMo, a discrete diffusion-style framework, which extends masked modeling to bidirectional text--motion understanding and generation. Unlike…

Computer Vision and Pattern Recognition · Computer Science 2026-02-09 Ning Zhang , Zhengyu Li , Kwong Weng Loh , Mingxi Xu , Qi Wang , Zhengyu Wen , Xiaoyu He , Wei Zhao , Kehong Gong , Mingyuan Zhang

Diffusion-based models have gained significant popularity for text-to-image generation due to their exceptional image-generation capabilities. A risk with these models is the potential generation of inappropriate content, such as biased or…

Computer Vision and Pattern Recognition · Computer Science 2024-03-29 Hang Li , Chengzhi Shen , Philip Torr , Volker Tresp , Jindong Gu

While diffusion models excel at generating high-quality images, prior work reports a significant performance gap between diffusion and autoregressive (AR) methods in language modeling. In this work, we show that simple masked discrete…

Recently, continuous diffusion models (CDM) have been introduced into non-autoregressive (NAR) text-to-text generation. However, the discrete nature of text increases the difficulty of CDM to generate coherent and fluent texts, and also…

Computation and Language · Computer Science 2023-05-09 Kun Zhou , Yifan Li , Wayne Xin Zhao , Ji-Rong Wen

Diffusion language models offer unique benefits over autoregressive models due to their potential for parallelized generation and controllability, yet they lag in likelihood modeling and are limited to fixed-length generation. In this work,…

Recovering degraded low-resolution text images is challenging, especially for Chinese text images with complex strokes and severe degradation in real-world scenarios. Ensuring both text fidelity and style realness is crucial for…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Yuzhe Zhang , Jiawei Zhang , Hao Li , Zhouxia Wang , Luwei Hou , Dongqing Zou , Liheng Bian

The rapid evolution of artificial intelligence in drug discovery encounters challenges with generalization and extensive training, yet Large Language Models (LLMs) offer promise in reshaping interactions with complex molecular data. Our…

Biomolecules · Quantitative Biology 2024-12-20 He Cao , Zijing Liu , Xingyu Lu , Yuan Yao , Yu Li
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