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Missing data is a common challenge in studying treatment effects. In the context of mediation analysis, this paper addresses missingness in the mediator and outcome, focusing on identification. We first consider self-separated missingness…

Methodology · Statistics 2026-04-07 Trang Quynh Nguyen , Razieh Nabi , Fan Yang , Grace V. Ringlein , Elizabeth A. Stuart

Statistical mechanics has proven to be able to capture the fundamental rules underlying phenomena of social aggregation and opinion dynamics, well studied in disciplines like sociology and psychology. This approach is based on the…

Physics and Society · Physics 2016-01-13 Andrea Guazzini , Daniele Vilone , Franco Bagnoli

During the past few years, mediation analysis has gained increasing popularity across various research fields. The primary objective of mediation analysis is to examine the direct impact of exposure on outcome, as well as the indirect…

Computation · Statistics 2023-05-18 Haixiang Zhang , Xin Li

Influence function (IF)-based estimators are widely used in mediation analysis due to their modeling flexibility, but standard implementations require direct estimation of the distribution functions of the mediator and treatment variables.…

Methodology · Statistics 2026-02-10 Chang Liu , AmirEmad Ghassami

Multi-modal data-sets are ubiquitous in modern applications, and multi-modal Variational Autoencoders are a popular family of models that aim to learn a joint representation of the different modalities. However, existing approaches suffer…

Machine Learning · Computer Science 2023-12-19 Mustapha Bounoua , Giulio Franzese , Pietro Michiardi

Estimating individual-level treatment effect from observational data is a fundamental problem in causal inference and has attracted increasing attention in the fields of education, healthcare, and public policy.In this work, we concentrate…

Machine Learning · Computer Science 2025-07-10 Hui Meng , Keping Yang , Xuyu Peng , Bo Zheng

Causal variance decompositions for a given disease-specific quality indicator can be used to quantify differences in performance between hospitals or health care providers. While variance decompositions can demonstrate variation in quality…

Methodology · Statistics 2023-01-26 Bo Chen , Keith A. Lawson , Antonio Finelli , Olli Saarela

Learning individual-level causal effects from observational data, such as inferring the most effective medication for a specific patient, is a problem of growing importance for policy makers. The most important aspect of inferring causal…

Machine Learning · Statistics 2017-11-07 Christos Louizos , Uri Shalit , Joris Mooij , David Sontag , Richard Zemel , Max Welling

A key objective of decomposition analysis is to identify a factor (the 'mediator') contributing to disparities in an outcome between social groups. In decomposition analysis, a scholarly interest often centers on estimating how much the…

Methodology · Statistics 2022-05-27 Soojin Park , Suyeon Kang , Chioun Lee , Shujie Ma

Dynamic network analysis has found an increasing interest in the literature because of the importance of different kinds of dynamic social networks, biological networks, and economic networks. Most available probability and statistical…

Methodology · Statistics 2017-10-18 Elynn Yi Chen , Rong Chen

Approving and assessing new drugs is complex because multiple criteria must be considered simultaneously. A common approach is benefit-risk analysis, often conducted within a Bayesian framework to account for uncertainty and combine data…

The process of generating data such as images is controlled by independent and unknown factors of variation. The retrieval of these variables has been studied extensively in the disentanglement, causal representation learning, and…

Machine Learning · Computer Science 2023-09-26 Gaël Gendron , Michael Witbrock , Gillian Dobbie

In response to the unique challenge created by high-dimensional mediators in mediation analysis, this paper presents a novel procedure for testing the nullity of the mediation effect in the presence of high-dimensional mediators. The…

Methodology · Statistics 2025-05-28 Yinan Lin , Zijian Guo , Baoluo Sun , Zhenhua Lin

It is often of interest to decompose a total effect of an exposure into the component that acts on the outcome through some mediator and the component that acts independently through other pathways. Said another way, we are interested in…

Statistics Theory · Mathematics 2016-01-21 Peng Ding , Tyler J. VanderWeele

Unscheduled treatment interruptions may lead to reduced quality of care in radiation therapy (RT). Identifying the RT prescription dose effects on the outcome of treatment interruptions, mediated through doses distributed into different…

Methodology · Statistics 2024-09-25 Zijin Liu , Zhihui Liu , Ali Hosni , John Kim , Bei Jiang , Olli Saarela

Estimation of treatment efficacy of real-world clinical interventions involves working with continuous outcomes such as time-to-death, re-hospitalization, or a composite event that may be subject to censoring. Counterfactual reasoning in…

Machine Learning · Computer Science 2022-08-11 Chirag Nagpal , Mononito Goswami , Keith Dufendach , Artur Dubrawski

Online experimentation is at the core of Booking.com's customer-centric product development. While randomised controlled trials are a powerful tool for estimating the overall effects of product changes on business metrics, they often fall…

Human-Computer Interaction · Computer Science 2018-10-31 Bahattin Tolga Öztan , Zoé van Havre , Caio Gomes , Lukas Vermeer

Observational cohort data is an important source of information for understanding the causal effects of treatments on survival and the degree to which these effects are mediated through changes in disease-related risk factors. However,…

Methodology · Statistics 2026-05-20 Saurabh Bhandari , Michael J. Daniels , Juned Siddique

The use of causal mediation analysis to evaluate the pathways by which an exposure affects an outcome is widespread in the social and biomedical sciences. Recent advances in this area have established formal conditions for identification…

Methodology · Statistics 2018-08-14 Isabel R. Fulcher , Xu Shi , Eric J. Tchetgen Tchetgen

The incorporation of causal inference in mediation analysis has led to theoretical and methodological advancements -- effect definitions with causal interpretation, clarification of assumptions required for effect identification, and an…

Methodology · Statistics 2022-10-31 Trang Quynh Nguyen , Ian Schmid , Elizabeth A. Stuart