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Black-box deep learning approaches have showcased significant potential in the realm of medical image analysis. However, the stringent trustworthiness requirements intrinsic to the medical field have catalyzed research into the utilization…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Yequan Bie , Luyang Luo , Hao Chen

With the ongoing development of deep learning, an increasing number of AI models have surpassed the performance levels of human clinical practitioners. However, the prevalence of AI diagnostic products in actual clinical practice remains…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Chenglong Wang , Yinqiao Yi , Yida Wang , Chengxiu Zhang , Yun Liu , Kensaku Mori , Mei Yuan , Guang Yang

Concept Bottleneck Models (CBMs) provide a basis for semantic abstractions within a neural network architecture. Such models have primarily been seen through the lens of interpretability so far, wherein they offer transparency by inferring…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Deepika SN Vemuri , Gautham Bellamkonda , Aditya Pola , Vineeth N Balasubramanian

Machine learning models that first learn a representation of a domain in terms of human-understandable concepts, then use it to make predictions, have been proposed to facilitate interpretation and interaction with models trained on…

Machine Learning · Computer Science 2020-12-08 Isaac Lage , Finale Doshi-Velez

Complex deep learning models show high prediction tasks in various clinical prediction tasks but their inherent complexity makes it more challenging to explain model predictions for clinicians and healthcare providers. Existing research on…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Sean C. Yu , Thomas Kannampallil , Zachary Abrams , Andrew Michelson , Philip R. O. Payne

Representation learning offers a conduit to elucidate distinctive features within the latent space and interpret the deep models. However, the randomness of lesion distribution and the complexity of low-quality factors in medical images…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Qingshan Hou , Shuai Cheng , Peng Cao , Jinzhu Yang , Xiaoli Liu , Osmar R. Zaiane , Yih Chung Tham

The 3D simulation model of the lung was established by using the reconstruction method. A computer aided pulmonary nodule detection model was constructed. The process iterates over the images to refine the lung nodule recognition model…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Yutian Yang , Hongjie Qiu , Yulu Gong , Xiaoyi Liu , Yang Lin , Muqing Li

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. In this paper, we propose a novel interpretable approach that combines attribute regularization of the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin I. Bercea , Julia A. Schnabel

Lung nodule malignancy prediction is an essential step in the early diagnosis of lung cancer. Besides the difficulties commonly discussed, the challenges of this task also come from the ambiguous labels provided by annotators, since deep…

Image and Video Processing · Electrical Eng. & Systems 2021-04-26 Zehui Liao , Yutong Xie , Shishuai Hu , Yong Xia

To increase the trustworthiness of deep neural networks, it is critical to improve the understanding of how they make decisions. This paper introduces a novel unsupervised concept-based model for image classification, named Learnable…

Machine Learning · Computer Science 2025-06-04 Francesco De Santis , Philippe Bich , Gabriele Ciravegna , Pietro Barbiero , Danilo Giordano , Tania Cerquitelli

Lung Cancer is the most common cause of cancer-related death worldwide. Early and automatic diagnosis of Solitary Pulmonary Nodules (SPN) in Computer Tomography (CT) chest scans can provide early treatment as well as doctor liberation from…

Image and Video Processing · Electrical Eng. & Systems 2020-03-31 Ioannis D. Apostolopoulos

We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Onur Ozdemir , Rebecca L. Russell , Andrew A. Berlin

Recently, intelligent analysis of lung nodules with the assistant of computer aided detection (CAD) techniques can improve the accuracy rate of lung cancer diagnosis. However, existing CAD systems and pulmonary datasets mainly focus on…

Image and Video Processing · Electrical Eng. & Systems 2024-06-27 Muwei Jian , Haoran Zhang , Mingju Shao , Hongyu Chen , Huihui Huang , Yanjie Zhong , Changlei Zhang , Bin Wang , Penghui Gao

Many interpretable AI approaches have been proposed to provide plausible explanations for a model's decision-making. However, configuring an explainable model that effectively communicates among computational modules has received less…

Machine Learning · Computer Science 2023-11-09 Jinyung Hong , Keun Hee Park , Theodore P. Pavlic

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical Computed Tomography (CT) images with 1.25 mm slice thickness is presented. The basic modules of our lung-CAD system, a…

Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu

We consider machine-learning-based malignancy prediction and lesion identification from clinical dermatological images, which can be indistinctly acquired via smartphone or dermoscopy capture. Additionally, we do not assume that images…

Computer Vision and Pattern Recognition · Computer Science 2021-04-07 Meng Xia , Meenal K. Kheterpal , Samantha C. Wong , Christine Park , William Ratliff , Lawrence Carin , Ricardo Henao

Lung cancer ranks as one of the leading causes of cancer diagnosis and is the foremost cause of cancer-related mortality worldwide. The early detection of lung nodules plays a pivotal role in improving outcomes for patients, as it enables…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Jiasen Zhang , Mingrui Yang , Weihong Guo , Brian A. Xavier , Michael Bolen , Xiaojuan Li

This paper proposes a novel and efficient method to build a Computer-Aided Diagnoses (CAD) system for lung nodule detection based on Computed Tomography (CT). This task was treated as an Object Detection on Video (VID) problem by imitating…

Computer Vision and Pattern Recognition · Computer Science 2017-12-15 Ning Li , Haopeng Liu , Bin Qiu , Wei Guo , Shijun Zhao , Kungang Li , Jie He

Nodule malignancy assessment is a complex, time-consuming and error-prone task. Current clinical practice requires measuring changes in size and density of the nodule at different time-points. State of the art solutions rely on 3D…

Image and Video Processing · Electrical Eng. & Systems 2020-05-27 Xavier Rafael-Palou , Anton Aubanell , Ilaria Bonavita , Mario Ceresa , Gemma Piella , Vicent Ribas , Miguel A. González Ballester