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This paper presents a quasi-sequential optimal design framework for toxicology experiments, specifically applied to sea urchin embryos. The authors propose a novel approach combining robust optimal design with adaptive, stage-based testing…

Methodology · Statistics 2025-03-04 Elvis Han Cui , Michael Collins , Jessica Munson , Weng Kee Wong

Designing molecules that must satisfy multiple, often conflicting objectives is a central challenge in molecular discovery. The enormous size of chemical space and the cost of high-fidelity simulations have driven the development of machine…

Machine Learning · Statistics 2025-12-22 Madhav R. Muthyala , Farshud Sorourifar , Tianhong Tan , You Peng , Joel A. Paulson

We introduce a novel, fast, and efficient generative model built upon scattering covariances, the most recent iteration of the scattering transforms statistics. This model is designed to augment by several orders of magnitude the number of…

Cosmology and Nongalactic Astrophysics · Physics 2025-08-13 P. Campeti , J. -M. Delouis , L. Pagano , E. Allys , M. Lattanzi , M. Gerbino

Algorithm Distillation (AD) was recently proposed as a new approach to perform In-Context Reinforcement Learning (ICRL) by modeling across-episodic training histories autoregressively with a causal transformer model. However, due to…

Machine Learning · Computer Science 2025-06-18 Samuel Beaussant , Mehdi Mounsif

Recently, state space model (SSM) has gained great attention due to its promising performance, linear complexity, and long sequence modeling ability in both language and image domains. However, it is non-trivial to extend SSM to the point…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Jiuming Liu , Ruiji Yu , Yian Wang , Yu Zheng , Tianchen Deng , Weicai Ye , Hesheng Wang

The recent surge in State Space Models (SSMs), particularly the emergence of Mamba, has established them as strong alternatives or complementary modules to Transformers across diverse domains. In this work, we aim to explore the potential…

Sound · Computer Science 2025-07-10 Wei-Jaw Lee , Fang-Chih Hsieh , Xuanjun Chen , Fang-Duo Tsai , Yi-Hsuan Yang

We study sample-efficient molecular optimization under a limited budget of oracle evaluations. We propose MolLIBRA (MultimOdaLity and Language Integrated Bayesian and evolutionaRy optimizAtion), a genetic algorithm based framework that…

Neural and Evolutionary Computing · Computer Science 2026-02-10 Masahi Okada , Kazuki Sakai , Hiroaki Yoshida , Masaki Okoshi , Tadahiro Taniguchi

Recommender systems aim to estimate the dynamically changing user preferences and sequential dependencies between historical user behaviour and metadata. Although transformer-based models have proven to be effective in sequential…

Information Retrieval · Computer Science 2025-10-07 Mark Obozov , Makar Baderko , Stepan Kulibaba , Nikolay Kutuzov , Alexander Gasnikov

Sampling strategies in diffusion models are critical to molecular generation yet remain relatively underexplored. In this work, we investigate a broad spectrum of sampling methods beyond conventional defaults and reveal that sampling choice…

Chemical Physics · Physics 2025-06-24 Yuyan Ni , Shikun Feng , Wei-Ying Ma , Zhi-Ming Ma , Yanyan Lan

Saturn is an innovative platform that assists Foundation Model (FM) building and its integration with IT operations (Ops). It is custom-made to meet the requirements of data scientists, enabling them to effectively create and implement FMs…

Selective state space models (SSM), such as Mamba, have gained prominence for their effectiveness in modeling sequential data. Despite their outstanding empirical performance, a comprehensive theoretical understanding of deep selective SSM…

Machine Learning · Computer Science 2025-03-10 Thieu N Vo , Tung D. Pham , Xin T. Tong , Tan Minh Nguyen

Mutation testing is an effective approach to evaluate and strengthen software test suites, but its adoption is currently limited by the mutants' execution computational cost. Several strategies have been proposed to reduce this cost (a.k.a.…

Software Engineering · Computer Science 2021-03-15 Giovani Guizzo , Federica Sarro , Jens Krinke , Silvia Regina Vergilio

Modern large language models are built on sequence modeling via next-token prediction. While the Transformer remains the dominant architecture for sequence modeling, its quadratic decoding complexity in sequence length poses a major…

Machine Learning · Computer Science 2024-10-03 Bo Liu , Rui Wang , Lemeng Wu , Yihao Feng , Peter Stone , Qiang Liu

The landscape of computational building blocks of efficient image restoration architectures is dominated by a combination of convolutional processing and various attention mechanisms. However, convolutional filters, while efficient, are…

Image and Video Processing · Electrical Eng. & Systems 2025-01-23 Mohammad Shahab Sepehri , Zalan Fabian , Mahdi Soltanolkotabi

Recent advancements in imitation learning have been largely fueled by the integration of sequence models, which provide a structured flow of information to effectively mimic task behaviours. Currently, Decision Transformer (DT) and…

Machine Learning · Computer Science 2024-10-18 André Correia , Luís A. Alexandre

Token-free language models learn directly from raw bytes and remove the inductive bias of subword tokenization. Operating on bytes, however, results in significantly longer sequences. In this setting, standard autoregressive Transformers…

Computation and Language · Computer Science 2024-08-13 Junxiong Wang , Tushaar Gangavarapu , Jing Nathan Yan , Alexander M. Rush

Image generation models have encountered challenges related to scalability and quadratic complexity, primarily due to the reliance on Transformer-based backbones. In this study, we introduce MaskMamba, a novel hybrid model that combines…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Wenchao Chen , Liqiang Niu , Ziyao Lu , Fandong Meng , Jie Zhou

Recently, deep Multi-Agent Reinforcement Learning (MARL) has demonstrated its potential to tackle complex cooperative tasks, pushing the boundaries of AI in collaborative environments. However, the efficiency of these systems is often…

Machine Learning · Computer Science 2024-12-23 Yangkun Chen , Kai Yang , Jian Tao , Jiafei Lyu

Recent advancements in tabular deep learning (DL) have led to substantial performance improvements, surpassing the capabilities of traditional models. With the adoption of techniques from natural language processing (NLP), such as language…

Machine Learning · Computer Science 2024-11-27 Anton Frederik Thielmann , Soheila Samiee

While the Mamba architecture demonstrates superior inference efficiency and competitive performance on short-context natural language processing (NLP) tasks, empirical evidence suggests its capacity to comprehend long contexts is limited…

Computation and Language · Computer Science 2025-01-03 Danlong Yuan , Jiahao Liu , Bei Li , Huishuai Zhang , Jingang Wang , Xunliang Cai , Dongyan Zhao