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The activity of the grid cell population in the medial entorhinal cortex (MEC) of the mammalian brain forms a vector representation of the self-position of the animal. Recurrent neural networks have been proposed to explain the properties…

Neurons and Cognition · Quantitative Biology 2022-11-08 Dehong Xu , Ruiqi Gao , Wen-Hao Zhang , Xue-Xin Wei , Ying Nian Wu

Grid cells in the entorhinal cortex of mammalian brains exhibit striking hexagon grid firing patterns in their response maps as the animal (e.g., a rat) navigates in a 2D open environment. In this paper, we study the emergence of the…

Neurons and Cognition · Quantitative Biology 2024-02-21 Dehong Xu , Ruiqi Gao , Wen-Hao Zhang , Xue-Xin Wei , Ying Nian Wu

Grid cells in the entorhinal cortex, together with head direction, place, speed and border cells, are major contributors to the organization of spatial representations in the brain. In this work we introduce a novel theoretical and…

Neurons and Cognition · Quantitative Biology 2019-07-25 Fabio Anselmi , Micah M. Murray , Benedetta Franceschiello

This paper proposes a representational model for grid cells. In this model, the 2D self-position of the agent is represented by a high-dimensional vector, and the 2D self-motion or displacement of the agent is represented by a matrix that…

Machine Learning · Statistics 2019-05-28 Ruiqi Gao , Jianwen Xie , Song-Chun Zhu , Ying Nian Wu

Grid cells in the medial entorhinal cortex (MEC) of the mammalian brain exhibit a strikingly regular hexagonal firing field over space. These cells are learned after birth and are thought to support spatial navigation but also more abstract…

Neurons and Cognition · Quantitative Biology 2024-10-07 Mufeng Tang , Helen Barron , Rafal Bogacz

Understanding how grid cells perform path integration calculations remains a fundamental problem. In this paper, we conduct theoretical analysis of a general representation model of path integration by grid cells, where the 2D self-position…

Neurons and Cognition · Quantitative Biology 2021-11-04 Ruiqi Gao , Jianwen Xie , Xue-Xin Wei , Song-Chun Zhu , Ying Nian Wu

Grid cells, discovered more than a decade ago [5], are neurons in the brain of mammals that fire when the animal is located near certain specific points in its familiar terrain. Intriguingly, these points form, for a single cell, a…

Neurons and Cognition · Quantitative Biology 2016-06-16 Christos H. Papadimitriou

To afford flexible behaviour, the brain must build internal representations that mirror the structure of variables in the external world. For example, 2D space obeys rules: the same set of actions combine in the same way everywhere (step…

Neurons and Cognition · Quantitative Biology 2025-03-04 William Dorrell , Peter E. Latham , Timothy E. J. Behrens , James C. R. Whittington

Research on network mechanisms and coding properties of grid cells assume that the firing rate of a grid cell in each of its fields is the same. Furthermore, proposed network models predict spatial regularities in the firing of inhibitory…

Neurons and Cognition · Quantitative Biology 2017-01-19 Benjamin Dunn , Daniel Wennberg , Ziwei Huang , Yasser Roudi

In this contribution, we demonstrate that Graph Neural Networks and Transformers can learn to reason about geometric constraints. We train them to predict spatial position of points in a discrete 2D grid from a set of constraints that…

Machine Learning · Computer Science 2026-03-03 Jan Hůla , David Mojžíšek , Jiří Janeček , David Herel , Mikoláš Janota

Encoding the distance between locations in space is essential for accurate navigation. Grid cells, a functional class of neurons in medial entorhinal cortex, are believed to support this computation. However, existing theories of how…

Neurons and Cognition · Quantitative Biology 2025-11-12 Pritipriya Dasbehera , Akshunna S. Dogra , William T. Redman

Decades of research on the neural code underlying spatial navigation have revealed a diverse set of neural response properties. The Entorhinal Cortex (EC) of the mammalian brain contains a rich set of spatial correlates, including grid…

Neurons and Cognition · Quantitative Biology 2018-05-11 Christopher J. Cueva , Xue-Xin Wei

This paper investigates whether the hexagonal structure of grid cells provides any performance benefits or if it merely represents a biologically convenient configuration. Utilizing the Vector-HaSH content addressable memory model as a…

Neurons and Cognition · Quantitative Biology 2024-10-17 Taahaa Mir , Peipei Yao , Kateri Duranceau , Isabeau Prémont-Schwarz

The grid cells (GCs) of the medial entorhinal cortex (MEC) and place cells (PCs) of the hippocampus are key elements of the brain network for the metric representation of space. Currently, any of the existing theoretical models can explain…

Neurons and Cognition · Quantitative Biology 2015-07-01 Andrey Stepanyuk

The grid firing patterns are thought to provide an efficient intrinsic metric capable of supporting universal spatial metric for mammalian spatial navigation in all environments. However, whether spatial representations of grid cells in the…

Neurons and Cognition · Quantitative Biology 2019-10-14 Taiping Zeng , XiaoLi Li , Bailu Si

The hippocampus encodes space through a striking gradient of place field sizes along its dorsal-ventral axis, yet the principles generating this continuous gradient from discrete grid cell inputs remain debated. We propose a unified…

Neurons and Cognition · Quantitative Biology 2025-06-06 Shujun Zhou , Guozhang Chen

Identifying the principles that determine neural population activity is paramount in the field of neuroscience. We propose the Principle of Isomorphism (PIso): population activity preserves the essential mathematical structures of the tasks…

Neurons and Cognition · Quantitative Biology 2025-10-17 Maoshen Xu , Fei Song , Yuxiu Shao , Bailu Si , Shanshan Qin

High-dimensional neural activity often reside in a low-dimensional subspace, referred to as neural manifolds. Grid cells in the medial entorhinal cortex provide a periodic spatial code that are organized near a toroidal manifold,…

Neurons and Cognition · Quantitative Biology 2025-10-22 Yuxing Jared Yao , Iris H. R. Yoon

For 20 years the beautiful structure in the grid cell code has presented an attractive puzzle: what computation do these representations subserve, and why does it manifest so curiously in neurons. The first question quickly attracted an…

Neurons and Cognition · Quantitative Biology 2026-03-06 William Dorrell , James C. R. Whittington

Grid cells in the entorhinal cortex fire when animals that are exploring a certain region of space occupy the vertices of a triangular grid that spans the environment. Different neurons feature triangular grids that differ in their…

Neurons and Cognition · Quantitative Biology 2017-01-04 Alessandro Sanzeni , Vijay Balasubramanian , Guido Tiana , Massimo Vergassola
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