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Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

Functional MRI (fMRI) and diffusion MRI (dMRI) are non-invasive imaging modalities that allow in-vivo analysis of a patient's brain network (known as a connectome). Use of these technologies has enabled faster and better diagnoses and…

Machine Learning · Computer Science 2016-12-06 Colin J Brown , Ghassan Hamarneh

The application of deep learning (DL) models to neuroimaging data poses several challenges, due to the high dimensionality, low sample size and complex temporo-spatial dependency structure of these datasets. Even further, DL models act as…

Machine Learning · Computer Science 2019-04-08 Armin W. Thomas , Hauke R. Heekeren , Klaus-Robert Müller , Wojciech Samek

Magnetic resonance imaging (MRI) has played a crucial role in fetal neurodevelopmental research. Structural annotations of MR images are an important step for quantitative analysis of the developing human brain, with Deep Learning providing…

Using deep learning models to recognize functional brain networks (FBNs) in functional magnetic resonance imaging (fMRI) has been attracting increasing interest recently. However, most existing work focuses on detecting static FBNs from…

Computer Vision and Pattern Recognition · Computer Science 2022-06-01 Yiheng Liu , Enjie Ge , Mengshen He , Zhengliang Liu , Shijie Zhao , Xintao Hu , Dajiang Zhu , Tianming Liu , Bao Ge

The human brain undergoes dynamic, potentially pathology-driven, structural changes throughout a lifespan. Longitudinal Magnetic Resonance Imaging (MRI) and other neuroimaging data are valuable for characterizing trajectories of change…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Agampreet Aulakh , Nils D. Forkert , Matthias Wilms

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by atypical functional brain connectivity and subtle structural alterations. rs-fMRI has been widely used to identify disruptions in large-scale brain…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Ansar Rahman , Hassan Shojaee-Mend , Sepideh Hatamikia

Generating realistic images to accurately predict changes in the structure of brain MRI is a crucial tool for clinicians. Such applications help assess patients' outcomes and analyze how diseases progress at the individual level. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-06-19 Mattia Litrico , Francesco Guarnera , Valerio Giuffirda , Daniele Ravì , Sebastiano Battiato

The anatomical structure of the brain can be observed via non-invasive techniques such as diffusion imaging. However, these are imperfect because they miss connections that are actually known to exist, especially long range…

Neurons and Cognition · Quantitative Biology 2015-02-25 Somwrita Sarkar , Sanjay Chawla , Donna Xu

The characterisation of the brain as a "connectome", in which the connections are represented by correlational values across timeseries and as summary measures derived from graph theory analyses, has been very popular in the last years.…

Machine Learning · Computer Science 2020-03-13 Tiago Azevedo , Luca Passamonti , Pietro Liò , Nicola Toschi

Brain networks from functional MRI have advanced our understanding of cortical activity and its disruption in neurodegenerative disorders. Recent work has increasingly focused on dynamic (time-varying) brain networks that capture both…

Neurons and Cognition · Quantitative Biology 2026-04-14 Nicolas Rubido , Venia Batziou , Marwan Fuad , Vesna Vuksanovic

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional…

Machine Learning · Computer Science 2019-11-20 Weida Li , Mingxia Liu , Fang Chen , Daoqiang Zhang

There have been several attempts to use deep learning based on brain fMRI signals to classify cognitive impairment diseases. However, deep learning is a hidden black box model that makes it difficult to interpret the process of…

Machine Learning · Computer Science 2024-11-20 Jeong-Jae Kim , Yeseul Jeon , SuMin Yu , Junggu Choi , Sanghoon Han

We propose a novel matrix autoencoder to map functional connectomes from resting state fMRI (rs-fMRI) to structural connectomes from Diffusion Tensor Imaging (DTI), as guided by subject-level phenotypic measures. Our specialized autoencoder…

Substantial evidence indicates that major psychiatric disorders are associated with distributed neural dysconnectivity, leading to strong interest in using neuroimaging methods to accurately predict disorder status. In this work, we are…

Machine Learning · Statistics 2014-03-26 Takanori Watanabe , Daniel Kessler , Clayton Scott , Michael Angstadt , Chandra Sripada

Dynamic networks have been increasingly used to characterize brain connectivity that varies during resting and task states. In such characterizations, a connectivity network is typically measured at each time point for a subject over a…

Methodology · Statistics 2023-03-23 Maoyu Zhang , Biao Cai , Wenlin Dai , Dehan Kong , Hongyu Zhao , Jingfei Zhang

Understanding the functional architecture of the brain in terms of networks is becoming increasingly common. In most fMRI applications functional networks are assumed to be stationary, resulting in a single network estimated for the entire…

We propose an integrated deep-generative framework, that jointly models complementary information from resting-state functional MRI (rs-fMRI) connectivity and diffusion tensor imaging (DTI) tractography to extract predictive biomarkers of a…

Deep learning has advanced fMRI analysis, yet it remains unclear which architectural inductive biases are most effective at capturing functional patterns in human brain activity. This issue is particularly important in small-sample…

Neurons and Cognition · Quantitative Biology 2025-09-23 Behdad Khodabandehloo , Reza Rajimehr

Functional Connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. However, a FC matrix is neither a natural image which contains shape and texture…

Medical Physics · Physics 2020-01-10 Xiaodan Xing , Qingfeng Li , Hao Wei , Minqing Zhang , Yiqiang Zhan , Xiang Sean Zhou , Zhong Xue , Feng Shi
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