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Thrombolytic occlusions in stroke, pulmonary embolism and the peripheral vasculature are increasingly treated with aspiration, a catheter-based approach that employs suction to extract clots through a hollow catheter lumen. Unfortunately,…

Medical Physics · Physics 2024-05-21 Li Gong , Alex R. Wright , Kullervo Hynynen , David E. Goertz

Thrombotic and chronic occlusions of large blood vessels are a major cause of mortality and morbidity, and so there is a need for improved treatments in many clinical circumstances. Endovascular ultrasound approaches have been shown to hold…

Medical Physics · Physics 2024-05-22 Jingjing Liu , Alex R. Wright , Kullervo Hynynen , David E. Goertz

Objective: The objective of this work is to introduce and demonstrate the effectiveness of a novel sensing modality for contact detection between an off-the-shelf aspiration catheter and a thrombus. Methods: A custom robotic actuator with a…

Robotics · Computer Science 2024-01-22 Jared Lawson , Madison Veliky , Colette P. Abah , Mary S. Dietrich , Rohan Chitale , Nabil Simaan

Histotripsy is a non-thermal focused ultrasound ablation method that destroys tissue through the generation and activity of acoustic cavitation. Intrinsic threshold histotripsy generates bubble clouds when the dominant negative pressure…

Medical Physics · Physics 2023-07-10 Connor Edsall , Laura Huynh , Tim Hall , Eli Vlaisavljevich

Focused ultrasound stimulated microbubbles have been shown to be capable of inducing blood flow shutdown and necrosis in a range of tissue types in an approach termed antivascular ultrasound or mechanical ablation. In oncology, this…

Medical Physics · Physics 2022-10-17 Xiaoxiao Zhao , Carly Pellow , David E. Goertz

Ultrasound is a key technology in healthcare, and it is being explored for non-invasive, wearable, continuous monitoring of vital signs. However, its widespread adoption in this scenario is still hindered by the size, complexity, and power…

In the emerging research field of bioelectronic medicine, it has been indicated that neuromodulation of the Vagus Nerve (VN) has the potential to treat various conditions such as epilepsy, depression, and autoimmune diseases. In order to…

An extended aperture has the potential to greatly improve ultrasound imaging performance. This work extends the effective aperture size by coherently compounding the received radio frequency data from multiple transducers. A framework is…

Medical Physics · Physics 2019-11-12 Laura Peralta , Alberto Gomez , Ying Luan , Baehyung Kim , Joseph V. Hajnal , Robert J. Eckersley

In this work, a novel approach for the detection and localisation of nonlinear guided waves often associated with the presence of damage in structural components is proposed. The method is active and consists of a piezoelectric transducer…

Applied Physics · Physics 2024-06-26 Paweł Kudela , Maciej Radzienski , Marco Miniaci , Piotr Fiborek , Wieslaw Ostachowicz

A cavity opto-electromechanical system is reported which combines the ultrasensitive transduction of cavity optomechanical systems with the electrical actuation of nanoelectromechanical systems. Ultrasensitive mechanical transduction is…

Quantum Physics · Physics 2015-05-19 Terry G. McRae , Kwan H. Lee , Glen I. Harris , Joachim Knittel , Warwick P. Bowen

Cavity optoelectromechanical regenerative amplification is demonstrated. An optical cavity enhances mechanical transduction, allowing sensitive measurement even for heavy oscillators. A 27.3 MHz mechanical mode of a microtoroid was…

Instrumentation and Detectors · Physics 2012-07-02 Michael A. Taylor , Alex Szorkovszky , Joachim Knittel , Kwan H. Lee , Terry G. McRae , Warwick P. Bowen

Multiple reflections between transducer and imaged object can naturally occur in ultrasound imaging and other acoustic sensing applications such as sonar. The repeated interaction of the emitted wavefront with the imaged object is…

Applied Physics · Physics 2021-06-17 Urs A. T. Hofmann , Sergio Pérez-López , Héctor Estrada , Daniel Razansky

We present a new technique using a frequency comb laser and optical cavities for performing ultrafast transient absorption spectroscopy with improved sensitivity. Resonantly enhancing the probe pulses, we demonstrate a sensitivity of…

Optics · Physics 2016-04-05 Melanie A. R. Reber , Yuning Chen , Thomas K. Allison

Sound scattering by a finite width beam on a single rigid body rotation vortex flow is detected by a linear array of transducers (both smaller than a flow cell), and analyzed using a revised scattering theory. Both the phase and amplitude…

Chaotic Dynamics · Physics 2009-11-10 Sh. Seifer , V. Steinberg

Biomedical applications requiring tissue diagnosis, activation, and treatment could be substantially leveraged by optical methods, owing to their unique feature set. However, their widespread application is severely limited by the strong…

Optics · Physics 2019-10-23 Maxim Cherkashin , Carsten Brenner , Georg Schmitz , Martin Hofmann

Effective clutter filtering is crucial in suppressing tissue clutter and extracting blood flow signal in Doppler ultrasound. Recent advances in eigen-based clutter filtering techniques have enabled ultrasound imaging of microvasculature…

Medical Physics · Physics 2024-05-21 Chengwu Huang , U-Wai Lok , Jingke Zhang , Hui Liu , Shigao Chen

Aspiration thrombectomy is a treatment option for ischemic stroke due to occlusions in large vessels. During the therapy a device is inserted into the vessel and suction is applied. A new one-dimensional model is introduced that is capable…

Numerical Analysis · Mathematics 2024-03-11 Michael Herty , Niklas Kolbe , Michael Neidlin

We present a bidirectional internal squeezing scheme for gravitational-wave detectors and show that it saturates the lowest known lower bounds on quantum noise from internal optical dissipation. The scheme uses two optical parametric…

General Relativity and Quantum Cosmology · Physics 2026-05-19 Sander M. Vermeulen , Umran Serra Koca , Lee McCuller

Transducers with larger aperture size are desirable in ultrasound imaging to improve resolution and image quality. A coherent multi-transducer ultrasound imaging system (CoMTUS) enables an extended effective aperture through coherent…

Nanomechanical resonators with increasingly high quality factors are enabled following recent insights into energy storage and loss mechanisms in nanoelectromechanical systems (NEMS). Consequently, efficient, non-dissipative transduction…

Mesoscale and Nanoscale Physics · Physics 2012-04-11 Thomas Faust , Peter Krenn , Stephan Manus , Jörg P. Kotthaus , Eva M. Weig
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