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Quantum optimization as a field has largely been restricted by the constraints of current quantum computing hardware, as limitations on size, performance, and fidelity mean most non-trivial problem instances won't fit on quantum devices.…

Quantum Physics · Physics 2024-05-03 Ibrahim Cameron , Teague Tomesh , Zain Saleem , Ilya Safro

Molecular docking (MD) is a crucial task in drug design, which predicts the position, orientation, and conformation of the ligand when bound to a target protein. It can be interpreted as a combinatorial optimization problem, where quantum…

Chemical Physics · Physics 2024-04-15 Yunting Li , Xiaopeng Cui , Zhaoping Xiong , Bowen Liu , Bi-Ying Wang , Runqiu Shu , Nan Qiao , Man-Hong Yung

Advances in quantum algorithms suggest a tentative scaling advantage on certain combinatorial optimization problems. Recent work, however, has also reinforced the idea that barren plateaus render variational algorithms ineffective on large…

Quantum Physics · Physics 2025-03-14 Tim Bode , Krish Ramesh , Tobias Stollenwerk

Even a minor boost in solving combinatorial optimization problems can greatly benefit multiple industries. Quantum computers, with their unique information processing capabilities, hold promise for delivering such enhancements. The…

Quantum Physics · Physics 2025-05-15 Gabriel Marin-Sanchez , David Amaro

Quantum algorithms have shown promise in solving Quadratic Unconstrained Binary Optimization (QUBO) problems, benefiting from their connection to the transverse field Ising model. Various Ising solvers, both classical and quantum, have…

Optimization and Control · Mathematics 2025-09-16 Zedong Peng , Daniel de Roux , David E. Bernal Neira

Analog models of quantum information processing, such as adiabatic quantum computation and analog quantum simulation, require the ability to subject a system to precisely specified Hamiltonians. Unfortunately, the hardware used to implement…

Quantum Physics · Physics 2014-02-25 Kevin C. Young , Robin Blume-Kohout , Daniel A. Lidar

We present a quantum algorithm for adiabatic state preparation on a gate-based quantum computer, with complexity polylogarithmic in the inverse error. Our algorithm digitally simulates the adiabatic evolution between two self-adjoint…

Quantum Physics · Physics 2022-03-04 Kianna Wan , Isaac H. Kim

Counter-diabatic (CD) driving provides a powerful route to fast and robust state preparation by suppressing diabatic excitations during finite-time evolution. Yet, deriving analytical CD protocols for complex systems remains challenging,…

Quantum Physics · Physics 2026-05-19 Julián Ferreiro-Vélez , Pablo García-Azorín , F. A. Cárdenas-López , Xi Chen

Quantum information processing is likely to have far-reaching impact in the field of artificial intelligence. While the race to build an error-corrected quantum computer is ongoing, noisy, intermediate-scale quantum (NISQ) devices provide…

Currently available quantum computers are prone to errors. Circuit optimization and error mitigation methods are needed to design quantum circuits to achieve better fidelity when executed on NISQ hardware. Dynamical decoupling (DD) is…

Quantum Physics · Physics 2022-09-05 Siyuan Niu , Aida Todri-Sanial

Noisy Intermediate-Scale Quantum (NISQ) devices lack error correction, limiting scalability for quantum algorithms. In this context, digital-analog quantum computing (DAQC) offers a more resilient alternative quantum computing paradigm that…

Quantum Physics · Physics 2024-10-11 Paula García-Molina , Ana Martin , Mikel Garcia de Andoin , Mikel Sanz

Counterdiabatic (CD) driving has the potential to speed up adiabatic quantum state preparation by suppressing unwanted excitations. However, existing approaches either require intractable classical computations or are based on…

Quantum Physics · Physics 2025-11-03 Jernej Rudi Finžgar , Simone Notarnicola , Madelyn Cain , Mikhail D. Lukin , Dries Sels

A major challenge in machine learning is the computational expense of training these models. Model training can be viewed as a form of optimization used to fit a machine learning model to a set of data, which can take up significant amount…

Machine Learning · Computer Science 2021-11-16 Prasanna Date , Thomas Potok

In this work, we introduce a novel Quadratic Binary Optimization (QBO) framework for training a quantized neural network. The framework enables the use of arbitrary activation and loss functions through spline interpolation, while Forward…

Machine Learning · Computer Science 2025-12-09 Wenxin Li , Chuan Wang , Hongdong Zhu , Qi Gao , Yin Ma , Hai Wei , Kai Wen

The Quadratic Unconstrained Binary Optimization (QUBO) model has gained prominence in recent years with the discovery that it unifies a rich variety of combinatorial optimization problems. By its association with the Ising problem in…

Data Structures and Algorithms · Computer Science 2019-11-06 Fred Glover , Gary Kochenberger , Yu Du

Achieving superpolynomial speedups for optimization has long been a central goal for quantum algorithms. Here we introduce Decoded Quantum Interferometry (DQI), a quantum algorithm that uses the quantum Fourier transform to reduce…

This Thesis delves into the development and implementation of quantum algorithms using the digital-analog quantum computing (DAQC) paradigm. It provides a comparative analysis of the performance of DAQC versus traditional digital…

Quantum Physics · Physics 2024-01-22 Ana Martin

Counterdiabatic driving realizes parameter displacement of an energy eigenstate of a given parametrized Hamiltonian using the adiabatic gauge potential. In this paper, we propose a universal method of digitized counterdiabatic driving,…

Quantum Physics · Physics 2026-02-03 Takuya Hatomura

Computing using a continuous-time evolution, based on the natural interaction Hamiltonian of the quantum computer hardware, is a promising route to building useful quantum computers in the near-term. Adiabatic quantum computing, quantum…

Quantum Physics · Physics 2019-03-06 James G. Morley , Nicholas Chancellor , Sougato Bose , Viv Kendon

We introduce a self-consistent mean-field quantum optimization algorithm that approximates the ground state of classical Ising Hamiltonians. The algorithm decomposes the problem into independent subproblems and treats the interactions…

Quantum Physics · Physics 2026-03-11 Maxime Dupont , Bhuvanesh Sundar , Meenambika Gowrishankar