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Simulating finite temperature phase transitions from first-principles is computationally challenging. Recently, molecular dynamics (MD) simulations using machine-learned force fields (MLFFs) have opened a new avenue for finite-temperature…

Electronic structure methods offer in principle accurate predictions of molecular properties, however, their applicability is limited by computational costs. Empirical methods are cheaper, but come with inherent approximations and are…

Chemical Physics · Physics 2023-11-16 Moritz Thürlemann , Sereina Riniker

Ab initio simulations are capable of providing detailed information of material behavior at the nanoscale. Simulating experimentally relevant situations is, however, often computationally intense. Using hybrid approaches between ab initio…

Computational Physics · Physics 2019-03-26 Michael Sluydts , Michiel Larmuseau , Johan Lauwaert , Stefaan Cottenier

Predicting polymer glass transition temperatures (Tg) with first-principles fidelity has long remained out of reach, as cooling multi-thousand-atom systems over a broad temperature range at acceptable rates exceeds the computational limits…

Materials Science · Physics 2026-01-27 Ashutosh Srivastava , Sakshi Agarwal , Shivank Shukla , Harikrishna Sahu , Rampi Ramprasad

Machine learning force fields (MLFF) have been proposed to accelerate molecular dynamics (MD) simulation, which finds widespread applications in chemistry and biomedical research. Even for the most data-efficient MLFFs, reaching chemical…

Quantitative Methods · Quantitative Biology 2023-06-07 Alexander Bukharin , Tianyi Liu , Shengjie Wang , Simiao Zuo , Weihao Gao , Wen Yan , Tuo Zhao

In moir\'e systems, the impact of lattice relaxation on electronic band structures is significant, yet the computational demands of first-principles relaxation are prohibitively high due to the large number of atoms involved. To address…

Mesoscale and Nanoscale Physics · Physics 2025-11-25 Jiaxuan Liu , Zhong Fang , Hongming Weng , Quansheng Wu

Machine learning encompasses a set of tools and algorithms which are now becoming popular in almost all scientific and technological fields. This is true for molecular dynamics as well, where machine learning offers promises of extracting…

Observing non-classical nucleation pathways remains challenging in simulations of complex materials with technological interests. This is because it requires very accurate force fields that can capture the whole complexity of their…

Materials Science · Physics 2022-08-10 Gaétan Laurens , Jacek Goniakowski , Julien Lam

Determining thermal and physical quantities across a broad temperature domain, especially up to the ultra-high temperature region, is a formidable theoretical and experimental challenge. At the same time it is essential for understanding…

Materials Science · Physics 2019-11-11 Yanhui Zhang , Alessandro Lunghi , Stefano Sanvito

Modern machine learning force fields (ML-FF) are able to yield energy and force predictions at the accuracy of high-level $ab~initio$ methods, but at a much lower computational cost. On the other hand, classical molecular mechanics force…

A force field as accurate as quantum mechanics (QM) and as fast as molecular mechanics (MM), with which one can simulate a biomolecular system efficiently enough and meaningfully enough to get quantitative insights, is among the most ardent…

In this study, we introduce a training protocol for developing machine learning force fields (MLFFs), capable of accurately determining energy barriers in catalytic reaction pathways. The protocol is validated on the extensively explored…

Chemical Physics · Physics 2023-08-23 Lars Schaaf , Edvin Fako , Sandip De , Ansgar Schäfer , Gábor Csányi

In this work, we introduce CHIPS-FF (Computational High-Performance Infrastructure for Predictive Simulation-based Force Fields), a universal, open-source benchmarking platform for machine learning force fields (MLFFs). This platform…

Materials Science · Physics 2025-03-20 Daniel Wines , Kamal Choudhary

Materials engineering using atomistic modeling is an essential tool for the development of qubits and quantum sensors. Traditional density-functional theory (DFT) does however not adequately capture the complete physics involved, including…

Machine learning force fields (MLFFs) have revolutionized molecular simulations by providing quantum mechanical accuracy at the speed of molecular mechanical computations. However, a fundamental reliance of these models on fixed-cutoff…

Chemical Physics · Physics 2026-01-08 Chu Wang , Lin Huang , Xinran Wei , Tao Qin , Arthur Jiang , Lixue Cheng , Jia Zhang

Machine learned interaction potentials (MLIPs) have become a critical component of large-scale, high-quality simulations for a range of chemical and biochemical systems. Yet, despite their in-distribution accuracy, molecular dynamics…

Chemical Physics · Physics 2026-04-09 Eric C. -Y. Yuan , Teresa Head-Gordon

Understanding how structural flexibility affects the properties of metal-organic frameworks (MOFs) is crucial for the design of better MOFs for targeted applications. Flexible MOFs can be studied with molecular dynamics simulations, whose…

Materials Science · Physics 2024-05-13 Abhishek Sharma , Stefano Sanvito

Machine learning force fields (MLFFs) are gaining attention as an alternative to classical force fields (FFs) by using deep learning models trained on density functional theory (DFT) data to improve interatomic potential accuracy. In this…

Chemical Physics · Physics 2025-03-25 Anseong Park , Jaeyune Ryu , Won Bo Lee

Machine Learning Potentials (MLPs) can enable simulations of ab initio accuracy at orders of magnitude lower computational cost. However, their effectiveness hinges on the availability of considerable datasets to ensure robust…

Machine Learning · Computer Science 2025-02-20 Sebastien Röcken , Julija Zavadlav

Molecular dynamics (MD) simulations allow atomistic insights into chemical and biological processes. Accurate MD simulations require computationally demanding quantum-mechanical calculations, being practically limited to short timescales…