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Accurately discriminating progressive stages of Alzheimer's Disease (AD) is crucial for early diagnosis and prevention. It often involves multiple imaging modalities to understand the complex pathology of AD, however, acquiring a complete…

Image and Video Processing · Electrical Eng. & Systems 2025-03-06 Seunghun Baek , Jaeyoon Sim , Guorong Wu , Won Hwa Kim

Anomaly detection in medical imaging is a challenging task in contexts where abnormalities are not annotated. This problem can be addressed through unsupervised anomaly detection (UAD) methods, which identify features that do not match with…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Geoffroy Oudoumanessah , Carole Lartizien , Michel Dojat , Florence Forbes

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide. In the absence of effective treatment options, early diagnosis is crucial for initiating management strategies to delay disease onset and slow down…

Machine Learning · Computer Science 2025-07-08 Saeed Jamshidiha , Alireza Rezaee , Farshid Hajati , Mojtaba Golzan , Raymond Chiong

Early and accurate diagnosis of Alzheimer's disease (AD) remains a critical challenge in neuroimaging-based clinical decision support systems. In this work, we propose a novel hybrid deep learning framework that integrates Topological Data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Faisal Ahmed

One of the main reasons for Alzheimer's disease (AD) is the disorder of some neural circuits. Existing methods for AD prediction have achieved great success, however, detecting abnormal neural circuits from the perspective of brain networks…

Machine Learning · Computer Science 2021-10-13 Junren Pan , Baiying Lei , Shuqiang Wang , Bingchuan Wang , Yong Liu , Yanyan Shen

Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

Alzheimer's disease (AD) emerges from a complex interplay of molecular, cellular, and network-level disturbances that are not easily captured by traditional reductionist frameworks. Conventional analyses of gene expression often rely on…

Quantitative Methods · Quantitative Biology 2025-12-11 Aya Samadzelkava

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…

Robust and accurate detection and segmentation of heterogenous tumors appearing in different anatomical organs with supervised methods require large-scale labeled datasets covering all possible types of diseases. Due to the unavailability…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Mehdi Astaraki , Francesca De Benetti , Yousef Yeganeh , Iuliana Toma-Dasu , Örjan Smedby , Chunliang Wang , Nassir Navab , Thomas Wendler

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major cause of dementia. Structural MRI is widely used to analyze AD-related brain atrophy; however, most deep learning methods rely on computationally expensive 3D…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Towhidul Islam , Mufti Mahmud

Early and accurate detection of Alzheimer's disease (AD) is crucial for enabling timely intervention and improving outcomes. However, developing reliable machine learning (ML) models for AD diagnosis is challenging due to limited labeled…

Machine Learning · Computer Science 2025-11-27 Abolfazl Moslemi , Hossein Peyvandi

This paper explores the utility of diffusion-based models for anomaly detection, focusing on their efficacy in identifying deviations in both compact and high-resolution datasets. Diffusion-based architectures, including Denoising Diffusion…

Machine Learning · Computer Science 2024-12-11 Aryan Bhosale , Samrat Mukherjee , Biplab Banerjee , Fabio Cuzzolin

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory and cognitive decline, affecting millions worldwide. Diagnosing AD is challenging due to its heterogeneous nature and variable progression. This…

Neurons and Cognition · Quantitative Biology 2024-10-22 Jiwon Youn , Dong Woo Kang , Hyun Kook Lim , Mansu Kim

Diffusion models have advanced unsupervised anomaly detection by improving the transformation of pathological images into pseudo-healthy equivalents. Nonetheless, standard approaches may compromise critical information during pathology…

Image and Video Processing · Electrical Eng. & Systems 2024-03-14 Cosmin I. Bercea , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the progressive accumulation of misfolded proteins, leading to cognitive decline. This study presents a novel stochastic modelling approach to simulate the…

Neurons and Cognition · Quantitative Biology 2024-11-06 Alec MacIver , Hina Shaheen

Early diagnosis of Alzheimer Diagnostics (AD) is a challenging task due to its subtle and complex clinical symptoms. Deep learning-assisted medical diagnosis using image recognition techniques has become an important research topic in this…

Image and Video Processing · Electrical Eng. & Systems 2024-01-26 Yihao Lin , Ximeng Li , Yan Zhang , Jinshan Tang

Cancer is a highly heterogeneous condition that can occur almost anywhere in the human body. 18F-fluorodeoxyglucose is an imaging modality commonly used to detect cancer due to its high sensitivity and clear visualisation of the pattern of…

Image and Video Processing · Electrical Eng. & Systems 2023-04-17 Ashay Patel , Petru-Danial Tudiosu , Walter H. L. Pinaya , Gary Cook , Vicky Goh , Sebastien Ourselin , M. Jorge Cardoso

Recent efforts towards video anomaly detection (VAD) try to learn a deep autoencoder to describe normal event patterns with small reconstruction errors. The video inputs with large reconstruction errors are regarded as anomalies at the test…

Computer Vision and Pattern Recognition · Computer Science 2021-09-03 Yuandu Lai , Yahong Han , Yaowei Wang

Convolutional Neural Network (CNN) techniques have proven to be very useful in image-based anomaly detection applications. CNN can be used as deep features extractor where other anomaly detection techniques are applied on these features.…

Machine Learning · Computer Science 2022-08-15 Sulaiman Aburakhia , Tareq Tayeh , Ryan Myers , Abdallah Shami

Unsupervised anomaly detection (UAD) in medical imaging is crucial for identifying pathological abnormalities without requiring extensive labeled data. However, existing diffusion-based UAD models rely solely on imaging features, limiting…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Harim Kim , Yuhan Wang , Minkyu Ahn , Heeyoul Choi , Yuyin Zhou , Charmgil Hong
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