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Despite their remarkable natural language understanding capabilities, Large Language Models (LLMs) have been underutilized for retrieval tasks. We present Search-R3, a novel framework that addresses this limitation by adapting LLMs to…

Computation and Language · Computer Science 2026-04-10 Yuntao Gui , James Cheng

Process reward models (PRMs) have shown success in complex reasoning tasks for large language models (LLMs). However, their application to machine translation (MT) remains underexplored due to the lack of systematic methodologies and…

Computation and Language · Computer Science 2025-09-22 Zhaopeng Feng , Jiahan Ren , Jiayuan Su , Jiamei Zheng , Hongwei Wang , Zuozhu Liu

With the development of next generation sequencing techniques, it is fast and cheap to determine protein sequences but relatively slow and expensive to extract useful information from protein sequences because of limitations of traditional…

Quantitative Methods · Quantitative Biology 2017-10-20 Renzhi Cao , Colton Freitas , Leong Chan , Miao Sun , Haiqing Jiang , Zhangxin Chen

The unprecedented advancements in Large Language Models (LLMs) have profoundly impacted natural language processing but have yet to fully embrace the realm of scalable vector graphics (SVG) generation. While LLMs encode partial knowledge of…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Ximing Xing , Juncheng Hu , Guotao Liang , Jing Zhang , Dong Xu , Qian Yu

Large language models (LLMs) have demonstrated impressive performance on natural language tasks, but their decision-making processes remain largely opaque. Existing explanation methods either suffer from limited faithfulness to the model's…

Computation and Language · Computer Science 2025-06-03 Bowen Wei , Mehrdad Fazli , Ziwei Zhu

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

Computation and Language · Computer Science 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Large language models (LLMs) demonstrate extraordinary abilities in a wide range of natural language processing (NLP) tasks. In this paper, we show that, beyond text understanding capability, LLMs are capable of processing text layouts that…

Computation and Language · Computer Science 2024-08-29 Weiming Li , Manni Duan , Dong An , Yan Shao

Large Language Models (LLMs) offer a transparent brain with accessible parameters that encode extensive knowledge, which can be analyzed, located and transferred. Consequently, a key research challenge is to transcend traditional knowledge…

Computation and Language · Computer Science 2025-05-21 Yuqiao Tan , Shizhu He , Kang Liu , Jun Zhao

Peptide classification tasks, such as predicting toxicity and HIV inhibition, are fundamental to bioinformatics and drug discovery. Traditional approaches rely heavily on handcrafted encodings of one-dimensional (1D) peptide sequences,…

Artificial Intelligence · Computer Science 2025-11-14 Vincent Schilling , Akshat Dubey , Georges Hattab

Video Large Language Models (Video LLMs) have shown promising capabilities in video comprehension, yet they struggle with tracking temporal changes and reasoning about temporal relationships. While previous research attributed this…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Lei Li , Yuanxin Liu , Linli Yao , Peiyuan Zhang , Chenxin An , Lean Wang , Xu Sun , Lingpeng Kong , Qi Liu

Large language models (LLMs), especially Explicit Long Chain-of-Thought (CoT) reasoning models like DeepSeek-R1 and QWQ, have demonstrated powerful reasoning capabilities, achieving impressive performance in commonsense reasoning and…

Computation and Language · Computer Science 2025-08-13 Jiatong Li , Weida Wang , Qinggang Zhang , Junxian Li , Di Zhang , Changmeng Zheng , Shufei Zhang , Xiaoyong Wei , Qing Li

Topic modeling is a widely used technique for revealing underlying thematic structures within textual data. However, existing models have certain limitations, particularly when dealing with short text datasets that lack co-occurring words.…

Artificial Intelligence · Computer Science 2023-12-18 Han Wang , Nirmalendu Prakash , Nguyen Khoi Hoang , Ming Shan Hee , Usman Naseem , Roy Ka-Wei Lee

Learning language of protein sequences, which captures non-local interactions between amino acids close in the spatial structure, is a long-standing bioinformatics challenge, which requires at least context-free grammars. However, complex…

Formal Languages and Automata Theory · Computer Science 2019-03-20 Witold Dyrka , François Coste , Juliette Talibart

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein function or structure. Existing approaches usually pretrain protein language models on a large number of unlabeled amino acid…

Machine Learning · Computer Science 2023-01-31 Zuobai Zhang , Minghao Xu , Arian Jamasb , Vijil Chenthamarakshan , Aurelie Lozano , Payel Das , Jian Tang

Protein retrieval, which targets the deconstruction of the relationship between sequences, structures and functions, empowers the advancing of biology. Basic Local Alignment Search Tool (BLAST), a sequence-similarity-based algorithm, has…

Information Retrieval · Computer Science 2025-01-06 Yuxuan Wu , Xiao Yi , Yang Tan , Huiqun Yu , Guisheng Fan , Gaowei Zheng

Proteins perform their biological functions through three-dimensional structures encoded by amino acid sequences, and ligand-binding protein co-design requires models that generate sequence-structure compatible proteins under explicit…

Biomolecules · Quantitative Biology 2026-05-28 Chen Wei , Fanding Xu , Minghao Sun , Zhiyuan Liu , Lin Wang , Tianrui Jia , Yihang Zhou , Yang Zhang

Emotion recognition in speech presents a complex multimodal challenge, requiring comprehension of both linguistic content and vocal expressivity, particularly prosodic features such as fundamental frequency, intensity, and temporal…

Context-free and context-sensitive formal grammars are often regarded as more appropriate to model proteins than regular level models such as finite state automata and Hidden Markov Models. In theory, the claim is well founded in the fact…

Formal Languages and Automata Theory · Computer Science 2017-01-30 Witold Dyrka , François Coste , Olgierd Unold , Łukasz Culer , Agnieszka Kaczmarek

Simile interpretation is a crucial task in natural language processing. Nowadays, pre-trained language models (PLMs) have achieved state-of-the-art performance on many tasks. However, it remains under-explored whether PLMs can interpret…

Computation and Language · Computer Science 2022-03-17 Qianyu He , Sijie Cheng , Zhixu Li , Rui Xie , Yanghua Xiao

Protein representation learning has primarily benefited from the remarkable development of language models (LMs). Accordingly, pre-trained protein models also suffer from a problem in LMs: a lack of factual knowledge. The recent solution…

Machine Learning · Computer Science 2023-02-16 Hong-Yu Zhou , Yunxiang Fu , Zhicheng Zhang , Cheng Bian , Yizhou Yu