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Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…

Soft Condensed Matter · Physics 2024-02-08 A. Ghafarollahi , M. J. Buehler

Text generation has become one of the most important yet challenging tasks in natural language processing (NLP). The resurgence of deep learning has greatly advanced this field by neural generation models, especially the paradigm of…

Computation and Language · Computer Science 2021-05-26 Junyi Li , Tianyi Tang , Wayne Xin Zhao , Ji-Rong Wen

Pre-trained Language Model (PLM) has become a representative foundation model in the natural language processing field. Most PLMs are trained with linguistic-agnostic pre-training tasks on the surface form of the text, such as the masked…

Computation and Language · Computer Science 2022-11-11 Yiming Cui , Wanxiang Che , Shijin Wang , Ting Liu

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

While pre-trained language models (LMs) have brought great improvements in many NLP tasks, there is increasing attention to explore capabilities of LMs and interpret their predictions. However, existing works usually focus only on a certain…

Computation and Language · Computer Science 2022-07-29 Yaozong Shen , Lijie Wang , Ying Chen , Xinyan Xiao , Jing Liu , Hua Wu

Deep neural networks have achieved remarkable performance in various text-based tasks but often lack interpretability, making them less suitable for applications where transparency is critical. To address this, we propose ProtoLens, a novel…

Computation and Language · Computer Science 2024-10-25 Bowen Wei , Ziwei Zhu

Vision-language models are integral to computer vision research, yet many high-performing models remain closed-source, obscuring their data, design and training recipe. The research community has responded by using distillation from…

Recently, speech representation learning has improved many speech-related tasks such as speech recognition, speech classification, and speech-to-text translation. However, all the above tasks are in the direction of speech understanding,…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-22 He Bai , Renjie Zheng , Junkun Chen , Xintong Li , Mingbo Ma , Liang Huang

Text representation plays a critical role in tasks like clustering, retrieval, and other downstream applications. With the emergence of large language models (LLMs), there is increasing interest in harnessing their capabilities for this…

Computation and Language · Computer Science 2025-12-25 Yeqin Zhang , Yizheng Zhao , Chen Hu , Binxing Jiao , Daxin Jiang , Ruihang Miao , Cam-Tu Nguyen

Large Language Models (LLMs) have revolutionised the field of Natural Language Processing (NLP) and have achieved state-of-the-art performance in practically every task in this field. However, the prevalent approach used in text generation,…

Computation and Language · Computer Science 2024-08-12 Nicolo Micheletti , Samuel Belkadi , Lifeng Han , Goran Nenadic

Recently, prompt tuning \cite{lester2021power} has gradually become a new paradigm for NLP, which only depends on the representation of the words by freezing the parameters of pre-trained language models (PLMs) to obtain remarkable…

Computation and Language · Computer Science 2022-01-31 Pan He , Yuxi Chen , Yan Wang , Yanru Zhang

Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling…

Quantitative Methods · Quantitative Biology 2025-01-08 Benoit Gaujac , Jérémie Donà , Liviu Copoiu , Timothy Atkinson , Thomas Pierrot , Thomas D. Barrett

Pre-trained language models (PLMs) like BERT are being used for almost all language-related tasks, but interpreting their behavior still remains a significant challenge and many important questions remain largely unanswered. In this work,…

Computation and Language · Computer Science 2021-09-28 Samuel Stevens , Yu Su

Pretrained language models (PLMs) have made significant strides in various natural language processing tasks. However, the lack of interpretability due to their ``black-box'' nature poses challenges for responsible implementation. Although…

Computation and Language · Computer Science 2023-11-10 Zhen Tan , Lu Cheng , Song Wang , Yuan Bo , Jundong Li , Huan Liu

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…

In contrast to their remarkable performance on general knowledge QA, the true abilities of Large Language Models (LLMs) in tasks demanding deep, specialized reasoning, such as in protein biology, have yet to be thoroughly investigated.…

Quantitative Methods · Quantitative Biology 2025-12-30 Dingyi Rong , Zijian Chen , Qi Jia , Kaiwei Zhang , Haotian Lu , Guangtao Zhai , Ning Liu

In recent years, Large Language Models (LLMs) have emerged as a prominent area of interest across various research domains, including Process Mining (PM). Current applications in PM have predominantly centered on prompt engineering…

Computation and Language · Computer Science 2025-09-04 Rafael Seidi Oyamada , Jari Peeperkorn , Jochen De Weerdt , Johannes De Smedt

With the rise of pre-trained models in the 3D point cloud domain for a wide range of real-world applications, adapting them to downstream tasks has become increasingly important. However, conventional full fine-tuning methods are…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Geunyoung Jung , Soohong Kim , Kyungwoo Song , Jiyoung Jung

The meanings of words and phrases depend not only on where they are used (contexts) but also on who use them (writers). Pretrained language models (PLMs) are powerful tools for capturing context, but they are typically pretrained and…

Computation and Language · Computer Science 2023-09-15 Daisuke Oba , Naoki Yoshinaga , Masashi Toyoda
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