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The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and…

Computation and Language · Computer Science 2024-07-16 Biqing Qi , Kaiyan Zhang , Kai Tian , Haoxiang Li , Zhang-Ren Chen , Sihang Zeng , Ermo Hua , Hu Jinfang , Bowen Zhou

Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large…

Computation and Language · Computer Science 2023-11-13 Biqing Qi , Kaiyan Zhang , Haoxiang Li , Kai Tian , Sihang Zeng , Zhang-Ren Chen , Bowen Zhou

With recent Nobel Prizes recognising AI contributions to science, Large Language Models (LLMs) are transforming scientific research by enhancing productivity and reshaping the scientific method. LLMs are now involved in experimental design,…

Large Language Models (LLMs) are transforming scientific hypothesis generation and validation by enabling information synthesis, latent relationship discovery, and reasoning augmentation. This survey provides a structured overview of…

Hypothesis generation is a fundamental step in scientific discovery, yet it is increasingly challenged by information overload and disciplinary fragmentation. Recent advances in Large Language Models (LLMs) have sparked growing interest in…

Cancer clinical trials often face challenges in recruitment and engagement due to a lack of participant-facing informational and educational resources. This study investigated the potential of Large Language Models (LLMs), specifically…

Large language models (LLMs) have shown significant potential in scientific disciplines such as biomedicine, particularly in hypothesis generation, where they can analyze vast literature, identify patterns, and suggest research directions.…

Computation and Language · Computer Science 2025-06-10 Guangzhi Xiong , Eric Xie , Corey Williams , Myles Kim , Amir Hassan Shariatmadari , Sikun Guo , Stefan Bekiranov , Aidong Zhang

Despite the dramatic progress in Large Language Model (LLM) development, LLMs often provide seemingly plausible but not factual information, often referred to as hallucinations. Retrieval-augmented LLMs provide a non-parametric approach to…

Computation and Language · Computer Science 2023-11-09 Sai Munikoti , Anurag Acharya , Sridevi Wagle , Sameera Horawalavithana

Hypothesis formulation and testing are central to empirical research. A strong hypothesis is a best guess based on existing evidence and informed by a comprehensive view of relevant literature. However, with exponential increase in the…

Computation and Language · Computer Science 2024-03-27 Sai Koneru , Jian Wu , Sarah Rajtmajer

Large language models (LLMs) have demonstrated remarkable capabilities in various scientific domains, from natural language processing to complex problem-solving tasks. Their ability to understand and generate human-like text has opened up…

Computation and Language · Computer Science 2024-11-05 Guangzhi Xiong , Eric Xie , Amir Hassan Shariatmadari , Sikun Guo , Stefan Bekiranov , Aidong Zhang

In recent years, groundbreaking advancements in natural language processing have culminated in the emergence of powerful large language models (LLMs), which have showcased remarkable capabilities across a vast array of domains, including…

Computation and Language · Computer Science 2023-12-11 Microsoft Research AI4Science , Microsoft Azure Quantum

Large language models (LLMs) are becoming a one-fits-many solution, but they sometimes hallucinate or produce unreliable output. In this paper, we investigate how hypothesis ensembling can improve the quality of the generated text for the…

Computation and Language · Computer Science 2023-10-18 António Farinhas , José G. C. de Souza , André F. T. Martins

Large language models (LLMs) have achieved a degree of success in generating coherent and contextually relevant text, yet they remain prone to a significant challenge known as hallucination: producing information that is not substantiated…

Computation and Language · Computer Science 2024-10-28 Ray Li , Tanishka Bagade , Kevin Martinez , Flora Yasmin , Grant Ayala , Michael Lam , Kevin Zhu

Since the introduction of ChatGPT, large language models (LLMs) have demonstrated significant utility in various tasks, such as answering questions through retrieval-augmented generation. Context can be retrieved using a vectorized…

Computation and Language · Computer Science 2025-07-01 Ming Cheung

Hallucinations in large language models (LLMs), plausible but factually inaccurate text, are often viewed as undesirable. However, recent work suggests that such outputs may hold creative potential. In this paper, we investigate whether…

Computation and Language · Computer Science 2025-08-25 Shuzhou Yuan , Zhan Qu , Ashish Yashwanth Kangen , Michael Färber

Concerns regarding the propensity of Large Language Models (LLMs) to produce inaccurate outputs, also known as hallucinations, have escalated. Detecting them is vital for ensuring the reliability of applications relying on LLM-generated…

Computation and Language · Computer Science 2024-05-31 Ernesto Quevedo , Jorge Yero , Rachel Koerner , Pablo Rivas , Tomas Cerny

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

AI holds promise for transforming scientific processes, including hypothesis generation. Prior work on hypothesis generation can be broadly categorized into theory-driven and data-driven approaches. While both have proven effective in…

Artificial Intelligence · Computer Science 2025-01-10 Haokun Liu , Yangqiaoyu Zhou , Mingxuan Li , Chenfei Yuan , Chenhao Tan

Large language models (LLMs), including ChatGPT, Bard, and Llama, have achieved remarkable successes over the last two years in a range of different applications. In spite of these successes, there exist concerns that limit the wide…

Computation and Language · Computer Science 2024-01-17 Junliang Luo , Tianyu Li , Di Wu , Michael Jenkin , Steve Liu , Gregory Dudek

Large Language Models (LLMs) are increasingly applied to medical imaging tasks, including image interpretation and synthetic image generation. However, these models often produce hallucinations, which are confident but incorrect outputs…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Anindya Bijoy Das , Shahnewaz Karim Sakib , Shibbir Ahmed
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