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Computational chemistry has become an indispensable tool for generating data and insights, pervading all branches of experimental chemistry. Its most central concept is the potential energy hypersurface, key to all chemistry and materials…

Chemical Physics · Physics 2026-04-03 Raphael T. Husistein , Markus Reiher

Similar to other electron correlation methods, many-body perturbation theory methods based on Green functions, such as the so-called $GW$ approximation, suffer from the usual slow convergence of energetic properties with respect to the size…

Although quantum computation (QC) is regarded as a promising numerical method for computational quantum chemistry, current applications of quantum-chemistry calculations on quantum computers are limited to small molecules. This limitation…

We report a universal density-based basis-set incompleteness correction that can be applied to any wave function method. The present correction, which appropriately vanishes in the complete basis set (CBS) limit, relies on short-range…

This paper presents a strategy for efficient quantum circuit design for density estimation. The strategy is based on a quantum-inspired algorithm for density estimation and a circuit optimisation routine based on memetic algorithms. The…

There are several important solid-state systems, such as defects in solids, superconducting circuits and molecular qubits, for attractive candidates of quantum computations. Molecular qubits, which benefit from the power of chemistry for…

Quantum Physics · Physics 2017-06-29 Yingqiu Dai , Zhifu Shi , Yue Fu , Xi Qin , Shiwei Mu , Yang Wu , Ji-Hu Su , Lei Qin , Yuan-Qi Zhai , Yi-Fei Deng , Xing Rong , Jiangfeng Du

An alternative methodology to evaluate two-electron-repulsion integrals based on numerical approximation is proposed. Computational chemistry has branched into two major fields with methodologies based on quantum mechanics and classical…

Chemical Physics · Physics 2016-09-22 Pedro E. M. Lopes

Impressive progress has been made in the past decade in the study of technological applications of varied types of quantum systems. With industry giants like IBM laying down their roadmap for scalable quantum devices with more than…

Quantum Physics · Physics 2021-09-15 Rishabh Gupta , Sabre Kais , Raphael D. Levine

We present QEst, a procedure to systematically generate approximations for quantum circuits to reduce their CNOT gate count. Our approach employs circuit partitioning for scalability with procedures to 1) reduce circuit length using…

Quantum Physics · Physics 2021-08-31 Tirthak Patel , Ed Younis , Costin Iancu , Wibe de Jong , Devesh Tiwari

Quantum Bayesian Computation (QBC) is an emerging field that levers the computational gains available from quantum computers to provide an exponential speed-up in Bayesian computation. Our paper adds to the literature in two ways. First, we…

Machine Learning · Statistics 2023-03-07 Nick Polson , Vadim Sokolov , Jianeng Xu

The emergence of artificial intelligence (AI) accelerators like NVIDIA Tensor Cores offers new opportunities to speed up tensor-heavy scientific computations. However, applying them to quantum chemistry is challenging due to strict accuracy…

Chemical Physics · Physics 2026-04-20 Hua Huang , Wenkai Shao , Jeff Hammond

Modeling electronic systems is an important application for quantum computers. In the context of materials science, an important open problem is the computational description of chemical reactions on surfaces. In this work, we outline a…

During the noisy intermediate-scale quantum (NISQ) era, quantum computational approaches refined to overcome the challenge of limited quantum resources are highly valuable. However, the accuracy of the molecular properties predicted by most…

Quantum Physics · Physics 2023-12-20 Shih-Kai Chou , Jyh-Pin Chou , Alice Hu , Yuan-Chung Cheng , Hsi-Sheng Goan

A central problem in biophysics and computational drug design is accurate modeling of biomolecules. The current molecular dynamics simulation methods can answer how a molecule inhibits a cancerous cell signaling pathway, or the role of…

Quantum Physics · Physics 2019-10-31 Anurag Mishra , Alireza Shabani

A major milestone of quantum error correction is to achieve the fault-tolerance threshold beyond which quantum computers can be made arbitrarily accurate. This requires extraordinary resources and engineering efforts. We show that even…

Quantum Physics · Physics 2021-06-16 Miroslav Urbanek , Benjamin Nachman , Wibe A. de Jong

Quantum computing faces a key challenge: balancing the need for low circuit depth (crucial for fault tolerance) with the high accuracy required for complex computations like quantum chemistry and error correction, which typically require…

Quantum Physics · Physics 2025-11-21 Ioana Moflic , Alexandru Paler , Akash Kundu

Solving electronic structure problems is considered one of the most promising applications of quantum computing. However, due to limitations imposed by the coherence time of qubits in the Noisy Intermediate Scale Quantum (NISQ) era or the…

Quantum Physics · Physics 2025-03-20 Shuo Sun , Chandan Kumar , Kevin Shen , Elvira Shishenina , Christian B. Mendl

The abundant demand for deep learning compute resources has created a renaissance in low precision hardware. Going forward, it will be essential for simulation software to run on this new generation of machines without sacrificing…

Chemical Physics · Physics 2024-10-23 William Dawson , Katsuhisa Ozaki , Jens Domke , Takahito Nakajima

Applications of quantum simulation algorithms to obtain electronic energies of molecules on noisy intermediate-scale quantum (NISQ) devices require careful consideration of resources describing the complex electron correlation effects. In…

Quantum Physics · Physics 2020-04-17 Mekena Metcalf , Nicholas P. Bauman , Karol Kowalski , Wibe A. de Jong

In this work we introduce a general scheme for measurement based quantum computation in continuous variables. Our approach does not necessarily rely on the use of ancillary cluster states to achieve its aim, but rather on the detection of a…

Quantum Physics · Physics 2017-02-01 Giulia Ferrini , Jonathan Roslund , Francesco Arzani , Claude Fabre , Nicolas Treps